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Cyclobutylamine

Product Name
Cyclobutylamine
CAS No.
2516-34-9
Chemical Name
Cyclobutylamine
Synonyms
Cyclobutanamine;AMINOCYCLOBUTANE;obutyL;AURORA KA-7608;Ring-butylaMine;CYCLOBUTYLAMINE;1-Cyclobutanamine;CyclobutylaMine 98%;Cyclobutylamine,98%;Cyclobutane-1-amine
CBNumber
CB0134657
Molecular Formula
C4H9N
Formula Weight
71.12
MOL File
2516-34-9.mol
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Cyclobutylamine Property

Melting point:
133-135.5 °C(Solv: ligroine (8032-32-4); dichloromethane (75-09-2))
Boiling point:
81.5 °C752 mm Hg(lit.)
Density 
0.833 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.437(lit.)
Flash point:
24 °F
storage temp. 
2-8°C
pka
10.80±0.20(Predicted)
form 
Liquid
color 
Clear colorless to light yellow
Water Solubility 
slightly soluble
Sensitive 
Hygroscopic
BRN 
2069297
InChIKey
KZZKOVLJUKWSKX-UHFFFAOYSA-N
CAS DataBase Reference
2516-34-9(CAS DataBase Reference)
NIST Chemistry Reference
Cyclobutylamine(2516-34-9)
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Safety

Hazard Codes 
F,C,Xi
Risk Statements 
11-34-20/21/22-36/37/38
Safety Statements 
16-26-36/37/39-45-33-7/9
RIDADR 
UN 2733 3/PG 2
WGK Germany 
3
HazardClass 
3
PackingGroup 
II
HS Code 
29213000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
225185
Product name
Cyclobutylamine
Purity
98%
Packaging
1g
Price
$66.1
Updated
2024/03/01
Sigma-Aldrich
Product number
225185
Product name
Cyclobutylamine
Purity
98%
Packaging
5g
Price
$190
Updated
2024/03/01
TCI Chemical
Product number
A1036
Product name
Aminocyclobutane
Purity
>97.0%(GC)(T)
Packaging
1mL
Price
$45
Updated
2024/03/01
TCI Chemical
Product number
A1036
Product name
Aminocyclobutane
Purity
>97.0%(GC)(T)
Packaging
5mL
Price
$132
Updated
2024/03/01
Alfa Aesar
Product number
A13423
Product name
Cyclobutylamine, 98%
Packaging
1g
Price
$50.65
Updated
2024/03/01
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Cyclobutylamine Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to light yellow liquid

Uses

Cyclobutylamine is a substrate employed in a microwave-assisted synthesis of 7-azaindoles from dihalopyridines. Also it is a reactant in the preparation of imidazo[1,2-b]pyridazine derivatives as selective and orally available Mps1 (TTK) kinase inhibitors.

Preparation

The preparation of cyclobutylamine from cyclobutanecarboxylic acid and hydrazoic acid has been reported previously. Cyclobutylamine has also been prepared by the Hofmann-type rearrangement of cyclobutanecarboxamide. More recently it has been prepared in 82–87% overall yield from cyclobutanecarboxamide by oxidative rearrangement with lead tetraacetate or iodosobenzene diacetate.

Synthesis of cyclobutylamine

Purification Methods

It has been purified by steam distillation. The aqueous distillate (e.g. 2L) is acidified with 3N HCl (90mL) and evaporated to dryness in a vacuum. The hydrochloride is treated with a few mL of H2O, cooled in ice and a slush of KOH pellets ground in a little H2O is added slowly in portions and keeping the solution very cold. The amine separates as an oil from the strongly alkaline solution. The oil is collected, dried over solid KOH and distilled using a vacuum jacketed Vigreux column (p 11) and protected from CO2 using a soda lime tube. The fraction boiling at 79-83o is collected, dried over solid KOH for 2days and redistilled over a few pellets of KOH (b 80.5-81.5o). Best distil in a dry N2 atmosphere. The purity can be checked by GLC using a polyethylene glycol on Teflon column at 72o, 15 psi, flow rate of 102 mL/min of He. The sample can appear homogeneous but because of tailing it is not possible to tell if H2O is present. The NMR in CCl4 should show no signals less than 1 ppm from TMS. The hydrochloride has a multiplet at ca 1.5-2.6ppm (H 2,2,4,3,3,4,4), a quintet at 3.8 ppm (H 1) and a singlet at 4.75 for NH2 [Roberts & Chambers J Am Chem Soc 73 2509 1951]. The benzenesulfonamide has m 85-86o (from aqueous MeOH) and the benzoyl derivative has m 120.6-121.6o. [Roberts & Mazur J Am Chem Soc 73 2509 1951, Iffland et al. J Am Chem Soc 75 4044 1953, Werner & Casanova Jr Org Synth Coll Vol V 273 1973, Beilstein 12 IV 3.]

Cyclobutylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cyclobutylamine manufacturers

Hebei Duling International Trade Co. LTD
Product
Cyclobutylamine 2516-34-9
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Ton
Release date
2023-02-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cyclobutylamine 2516-34-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Hebei Mojin Biotechnology Co., Ltd
Product
Cyclobutylamine 2516-34-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-26

2516-34-9, CyclobutylamineRelated Search:


  • AURORA KA-7608
  • CYCLOBUTYLAMINE
  • AMINOCYCLOBUTANE
  • Cyclobutanamine
  • 1-Cyclobutanamine
  • Cyclobutane-1-amine
  • Cyclobutylamine,98%
  • Ring-butylaMine
  • CyclobutylaMine 98%
  • Cyclobutylamine,Aminocyclobutane
  • Cyclobutylamine (free state)
  • Aminocyclobutane &gt
  • obutyL
  • 2516-34-9
  • 2561-34-9
  • C4H9N
  • C4H7NH2
  • C4H9N1
  • AMINE
  • Simple 4-Membered Ring Compounds
  • Cyclobutanes & Cyclobutenes
  • Organic Building Blocks
  • Nitrogen Compounds
  • C2 to C6
  • Amines
  • Building Blocks
  • Imidazoles ,Homopiperidines
  • Cyclobutanes & Cyclobutenes
  • Simple 4-Membered Ring Compounds
  • cyclic compounds
  • Amines and Anilines