Cyclobutylamine

ChemicalBook > CAS DataBase List > Cyclobutylamine

Product Name: Cyclobutylamine
CAS No.: 2516-34-9
Chemical Name: Cyclobutylamine
Synonyms: Cyclobutanamine;AMINOCYCLOBUTANE;obutyL;AURORA KA-7608;Ring-butylaMine;CYCLOBUTYLAMINE;1-Cyclobutanamine;CyclobutylaMine 98%;Cyclobutylamine,98%;Cyclobutane-1-amine
CBNumber: CB0134657
Molecular Formula: C4H9N
Formula Weight: 71.12
MOL File: 2516-34-9.mol

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Cyclobutylamine Property

Melting point:: 133-135.5 °C(Solv: ligroine (8032-32-4); dichloromethane (75-09-2))
Boiling point:: 81.5 °C752 mm Hg(lit.)
Density: 0.833 g/mL at 25 °C(lit.)
refractive index: n20/D 1.437(lit.)
Flash point:: 24 °F
storage temp.: 2-8°C
pka: 10.80±0.20(Predicted)
form: Liquid
color: Clear colorless to light yellow
Water Solubility: slightly soluble
Sensitive: Hygroscopic
BRN: 2069297
InChIKey: KZZKOVLJUKWSKX-UHFFFAOYSA-N
CAS DataBase Reference: 2516-34-9(CAS DataBase Reference)
NIST Chemistry Reference: Cyclobutylamine(2516-34-9)

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Safety

Hazard Codes: F,C,Xi
Risk Statements: 11-34-20/21/22-36/37/38
Safety Statements: 16-26-36/37/39-45-33-7/9
RIDADR: UN 2733 3/PG 2
WGK Germany: 3
HazardClass: 3
PackingGroup: II
HS Code: 29213000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 225185
Product name: Cyclobutylamine
Purity: 98%
Packaging: 1g
Price: $66.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 225185
Product name: Cyclobutylamine
Purity: 98%
Packaging: 5g
Price: $190
Updated: 2024/03/01

TCI Chemical

Product number: A1036
Product name: Aminocyclobutane
Purity: >97.0%(GC)(T)
Packaging: 1mL
Price: $45
Updated: 2024/03/01

TCI Chemical

Product number: A1036
Product name: Aminocyclobutane
Purity: >97.0%(GC)(T)
Packaging: 5mL
Price: $132
Updated: 2024/03/01

Alfa Aesar

Product number: A13423
Product name: Cyclobutylamine, 98%
Packaging: 1g
Price: $50.65
Updated: 2024/03/01

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Cyclobutylamine Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to light yellow liquid

Uses

Cyclobutylamine is a substrate employed in a microwave-assisted synthesis of 7-azaindoles from dihalopyridines. Also it is a reactant in the preparation of imidazo[1,2-b]pyridazine derivatives as selective and orally available Mps1 (TTK) kinase inhibitors.

Preparation

The preparation of cyclobutylamine from cyclobutanecarboxylic acid and hydrazoic acid has been reported previously. Cyclobutylamine has also been prepared by the Hofmann-type rearrangement of cyclobutanecarboxamide. More recently it has been prepared in 82–87% overall yield from cyclobutanecarboxamide by oxidative rearrangement with lead tetraacetate or iodosobenzene diacetate.

Synthesis of cyclobutylamine

Purification Methods

It has been purified by steam distillation. The aqueous distillate (e.g. 2L) is acidified with 3N HCl (90mL) and evaporated to dryness in a vacuum. The hydrochloride is treated with a few mL of H2O, cooled in ice and a slush of KOH pellets ground in a little H2O is added slowly in portions and keeping the solution very cold. The amine separates as an oil from the strongly alkaline solution. The oil is collected, dried over solid KOH and distilled using a vacuum jacketed Vigreux column (p 11) and protected from CO2 using a soda lime tube. The fraction boiling at 79-83o is collected, dried over solid KOH for 2days and redistilled over a few pellets of KOH (b 80.5-81.5o). Best distil in a dry N2 atmosphere. The purity can be checked by GLC using a polyethylene glycol on Teflon column at 72o, 15 psi, flow rate of 102 mL/min of He. The sample can appear homogeneous but because of tailing it is not possible to tell if H2O is present. The NMR in CCl4 should show no signals less than 1 ppm from TMS. The hydrochloride has a multiplet at ca 1.5-2.6ppm (H 2,2,4,3,3,4,4), a quintet at 3.8 ppm (H 1) and a singlet at 4.75 for NH2 [Roberts & Chambers J Am Chem Soc 73 2509 1951]. The benzenesulfonamide has m 85-86o (from aqueous MeOH) and the benzoyl derivative has m 120.6-121.6o. [Roberts & Mazur J Am Chem Soc 73 2509 1951, Iffland et al. J Am Chem Soc 75 4044 1953, Werner & Casanova Jr Org Synth Coll Vol V 273 1973, Beilstein 12 IV 3.]

Cyclobutylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cyclobutylamine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cyclobutylamine 2516-34-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Hebei Weibang Biotechnology Co., Ltd

Product: Cyclobutylamine 2516-34-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-30

Hebei Fengjia New Material Co., Ltd

Product: Cyclobutylamine 2516-34-9
Price: US $4.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100000
Release date: 2024-08-08

2516-34-9, CyclobutylamineRelated Search:

N-(n-Butyl)thiophosphoric triamide Cyclohexylamine AMIKACIN DOBUTAMINE Salbutamol Albuterol sulfate Tetrabutylammonium bromide 3-Azetidinecarboxylic acid CYCLOBUTYL-ACETIC ACID tert-butyl cyclopropanecarboxylate Cyclopropylboronic acid Methyl cyclopropane carboxylate Sulfolane Cyclobutanecarboxylic acid Cyclobutanemethanol Cyclobutanecarbonitrile Cyclobutanol Cyclobutanone

AURORA KA-7608

CYCLOBUTYLAMINE

AMINOCYCLOBUTANE

Cyclobutanamine

1-Cyclobutanamine

Cyclobutane-1-amine

Cyclobutylamine,98%

Ring-butylaMine

CyclobutylaMine 98%

Cyclobutylamine,Aminocyclobutane

Cyclobutylamine (free state)

Aminocyclobutane &gt

obutyL

2516-34-9

2561-34-9

C4H9N

C4H7NH2

C4H9N1

AMINE

Simple 4-Membered Ring Compounds

Cyclobutanes & Cyclobutenes

Organic Building Blocks

Nitrogen Compounds

C2 to C6

Amines

Building Blocks

Imidazoles ,Homopiperidines

Cyclobutanes & Cyclobutenes

Simple 4-Membered Ring Compounds

cyclic compounds

Amines and Anilines