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EPROSARTAN

Product Name
EPROSARTAN
CAS No.
133040-01-4
Chemical Name
EPROSARTAN
Synonyms
Teveten;CS-1951;Navixen;EPROSARTAN;SKB 108566;SKF-108566J;SKF-108566);Eprosartan-d4;prop-1-en-1-yl);-1H-imidazol-1-yl)
CBNumber
CB0135346
Molecular Formula
C23H24N2O4S
Formula Weight
424.51
MOL File
133040-01-4.mol
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EPROSARTAN Property

Melting point:
250-253°C
storage temp. 
Sealed in dry,2-8°C
solubility 
Dichloromethane (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Yellow to Light Yellow
CAS DataBase Reference
133040-01-4
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Safety

Hazardous Substances Data
133040-01-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E590100
Product name
Eprosartan
Packaging
10mg
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
094012
Product name
Eprosartan
Purity
95+%
Packaging
1g
Price
$227
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0000548
Product name
EPROSARTAN
Purity
95.00%
Packaging
1G
Price
$284.55
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006807
Product name
EPROSARTAN-D4
Purity
95.00%
Packaging
5MG
Price
$501.55
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D33956
Product name
Eprosartan-d6
Packaging
1mg
Price
$600
Updated
2021/12/16
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EPROSARTAN Chemical Properties,Usage,Production

Description

Teveten was launched in Germany for the treatment of hypertension. There are several ways in which it has been prepared, the shortest of which is four steps; beginning with displacement of 2-butyl-4-chloroimidazole-5-carboxaldehyde with methyl 4-(bromomethyl)benzoate. Teveten is an angiotensin Ⅱ antagonist selective for the AT, subtype receptor. It is a potent, highly selective, competitve antagonist with no agonist activity. Duration of action is similar to Enalapril (greater than 12 hr) but Teveten had a faster onset. While it is orally active, it rapidly dissociates from the receptor. This is contrary to its prolonged duration of action, which presumably results from slow removal from compartments within tissue, cells or matrix around the AT, receptor. It is not bound by BSA.

Chemical Properties

Light-Yellow Solid

Originator

SmithKline Beecham (UK)

Uses

Prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. Antihypertensive

Uses

Eprosartan is a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. Eprosartan is an antihypertensive.

Uses

Eprosartan (E590100) impurity.

Definition

ChEBI: A member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.

brand name

Teveten

Clinical Use

Angiotensin-II antagonist
Hypertension

Drug interactions

Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia hypotension and renal impairment with ACE inhibitors and aliskiren.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
Epoetin: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Lithium: reduced excretion, possibility of enhanced lithium toxicity.
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Following oral and intravenous dosing with [14C] eprosartan in human subjects, eprosartan was the only drug-related compound found in the plasma and faeces. In the urine, approximately 20% of the radioactivity excreted was an acyl glucuronide of eprosartan with the remaining 80% being unchanged eprosartan
Eprosartan is eliminated by both biliary and renal excretion. Following intravenous [14C] eprosartan, about 61% of radioactivity is recovered in the faeces and about 37% in the urine. Following an oral dose of [14C] eprosartan, about 90% of radioactivity is recovered in the faeces and about 7% in the urine.

EPROSARTAN Preparation Products And Raw materials

Raw materials

Clotrimazole Methyl 4-(bromomethyl)benzoate 2-Carbethoxy-3-(2-thienyl)propanoic acid Methyl acrylate

Preparation Products

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EPROSARTAN Suppliers

Canada 1 China 87 Europe 2 India 12 South Korea 1 United Kingdom 4 United States 18 Global 125
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
UK GREEN SCIENTIFIC CO.,LIMITED
Tel
--
Fax
--
Email
sales@gs-chem.com
Country
United Kingdom
ProdList
6098
Advantage
47
Sequoia Research Products Ltd.
Tel
--
Fax
--
Email
sales@seqchem.com
Country
United Kingdom
ProdList
3113
Advantage
69
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View Lastest Price from EPROSARTAN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Eprosartan 133040-01-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09

133040-01-4, EPROSARTANRelated Search:

SB 206328 CINITAPRIDE HYDROGEN TARTRATE 4-(2-BUTYL-5-FORMYLIMIDAZOL-1-YLMETHYL)BENZOIC ACID Tacrolimus Losartan potassium Pregabalin Irbesartan Valsartan Eprosartan mesylate Olmesartan Medoxomil Tasosartan 4-Bromomethylbenzoic acid SB 201972 3-(2-THIENYL)PROPIONIC ACID Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate Epalrestat iMpurity 4-(Hydroxymethyl)benzoic acid α-Methylcinnamaldehyde

  • 4-[2-Butyl-5-(2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-benzoic acid
  • CS-1951
  • EPROSARTAN
  • Eprosartan Mysylate
  • (E)-3-[2-Butyl-1-[(4-carboxyphenyl)-methyl]imidazol-5-l]-2-(2-thienylmethyl)-2-propenoic Acid
  • ((E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoic Acid
  • SKF-108566)
  • SKF-108566J
  • Teveten
  • (E)- α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-y1]methylene]2-thiophenepropanoic acid
  • (E)-3-[2-Butyl-1-(4-carboxybenzyl)-1H-imidazol-5-yl]-2-(2-thienylmethyl)acrylic acid
  • 2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-
  • Des[2-(2-thienylMethyl)] Eprosartan-2-carboxylic Acid
  • (E)-2-Butyl-1-(p-carboxybenzyl)-α-2-thenyliMidazole-5-acrylic Acid
  • (αE)-α-[[2-Butyl-1-[(4-carboxyphenyl)Methyl]-1H-iMidazol-5-yl]Methylene]-2-thiophenepropanoic Acid
  • Navixen
  • SKB 108566
  • 2-[[2-Butyl-1-[[4-(carboxyphenyl)]Methyl]-1H-iMidazol-5-yl]Methylene]propanedioic Acid
  • 4-[[2-Butyl-5-(2,2-dicarboxyvinyl)-1H-iMidazol-1yl)Methylbenzoic Acid
  • Eprosartan-d4
  • (E)-4-((2-Butyl-5-(2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl)-1H-iMidazol-1-yl)Methyl)benzoic acid
  • -1H-imidazol-1-yl)
  • -4-((2-Butyl-5-(2-carboxy-3-(thiophen-2-yl)
  • prop-1-en-1-yl)
  • EPROSARTAN USP/EP/BP
  • Eprosartan D6 HClQ: What is Eprosartan D6 HCl Q: What is the CAS Number of Eprosartan D6 HCl Q: What is the storage condition of Eprosartan D6 HCl Q: What are the applications of Eprosartan D6 HCl
  • EprosartanQ: What is Eprosartan Q: What is the CAS Number of Eprosartan Q: What is the storage condition of Eprosartan Q: What are the applications of Eprosartan
  • TIANFU-CHEM EPROSARTAN
  • Eprosartan (SKF-108566J)
  • Eprosartan (E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]-imidazol-5-yl]-2-(2- thienyl methyl)-2-propenoic acid
  • Eprosartan in methanol
  • 133040-01-4
  • C23H24N2O4S
  • Aromatics
  • Heterocycles
  • Impurities
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds