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(R)-N-BOC-Propargylglycine

Product Name
(R)-N-BOC-Propargylglycine
CAS No.
63039-46-3
Chemical Name
(R)-N-BOC-Propargylglycine
Synonyms
Boc-D-propraglycine;RARECHEM BK PT 0259;Boc-D-Propargyl-Gly-OH;BOC-D-PROPARGYLGLYCINE;Boc-D-Gly(propargyl)-OH;N-Boc-D-Propargylglycine;Boc-(R)-2-Propargylglycine;(R)-N-BOC-PROPARGYLGLYCINE;Boc-D-Propargylglycine ,98%;Boc-D-Propargylglycine.DCHA
CBNumber
CB0138392
Molecular Formula
C10H15NO4
Formula Weight
213.23
MOL File
63039-46-3.mol
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(R)-N-BOC-Propargylglycine Property

Melting point:
86-88°
Boiling point:
353.22°C (rough estimate)
Density 
1.2177 (rough estimate)
refractive index 
1.4368 (estimate)
storage temp. 
2-8°C
pka
3.53±0.10(Predicted)
form 
Crystalline Powder
color 
Off-white to light beige
optical activity
-32.6364°(C=1.1311 g/100ml CHCL3)
InChI
InChI=1S/C10H15NO4/c1-5-6-7(8(12)13)11-9(14)15-10(2,3)4/h1,7H,6H2,2-4H3,(H,11,14)(H,12,13)/t7-/m1/s1
InChIKey
AMKHAJIFPHJYMH-SSDOTTSWSA-N
SMILES
C(O)(=O)[C@H](NC(OC(C)(C)C)=O)CC#C
CAS DataBase Reference
63039-46-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
HS Code 
29224985
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

TRC
Product number
B665880
Product name
Boc-D-Pra-OH
Packaging
500mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
M087
Product name
Boc-D-Propargylglycine
Packaging
1g
Price
$81
Updated
2021/12/16
Oakwood
Product number
048698
Product name
N-Boc-2-Propargyl-D-glycine
Packaging
250mg
Price
$150
Updated
2021/12/16
SynQuest Laboratories
Product number
4558-1-02
Product name
D-2-Propargylglycine, N-Boc protected
Packaging
1g
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB40101
Product name
Boc-D-Propargylglycine
Packaging
250mg
Price
$172.5
Updated
2021/12/16
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(R)-N-BOC-Propargylglycine Chemical Properties,Usage,Production

Chemical Properties

off-white to light beige crystalline powder

Uses

(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1]. (R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Synthesis

24424-99-5

23235-01-0

61172-66-5

Step 5: Preparation of (R)-2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid L-alkynylglycine (10 g) [prepared according to Schwyzer et al, Helv. Chim. Acta, 59, 2181 (1976)] was suspended in tetrahydrofuran (30 mL). To this suspension, water (30 mL), potassium carbonate (36.7 g) and di-tert-butyl dicarbonate (21.9 g) were added sequentially. Subsequently, additional water was added to completely dissolve the mixture and the resulting solution was stirred for 12 hours at room temperature. Upon completion of the reaction, the organic solvent was removed by evaporation. The remaining aqueous phase was washed with ether and then acidified with 1N aqueous citric acid to pH 3. The acidified aqueous phase was extracted with dichloromethane, and the organic phases were combined and the solvent was removed by evaporation to afford (R)-2-((tert-butoxycarbonyl)amino)pent-4-ynoic acid (18.9 g, 97% yield), and the product was ready to use in subsequent reactions without further purification.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

(R)-N-BOC-Propargylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-BOC-Propargylglycine Suppliers

Belgium 1 China 150 Europe 1 Germany 4 India 1 The Netherlands 1 United Kingdom 4 United States 23 Global 185
DSM Pharma Chemicals
Tel
--
Fax
--
Email
ian.freelance@dsm.com
Country
The Netherlands
ProdList
78
Advantage
30
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View Lastest Price from (R)-N-BOC-Propargylglycine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-D-Propargylglycine 63039-46-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-10-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
(R)-N-BOC-Propargylglycine 63039-46-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-10
Career Henan Chemical Co
Product
(R)-N-BOC-Propargylglycine 63039-46-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-24

63039-46-3, (R)-N-BOC-PropargylglycineRelated Search:

L-Propargylglycine (R)-METHYL-2-BOC-AMINO-4-PENTENOIC ACID METHYL-2-BOC-AMINO-4-PENTENOIC ACID DL-PROPARGYLGLYCINE (S)-N-BOC-Propargylglycine (R)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid L-Propargylglycine HCL (R)-2-aminopent-4-ynoic acid (R)-N-BOC-Propargylglycine 4-Pentyn-1-ol D-PROPARGYLGLYCINE 4-Fluorocinnamic acid 4-PENTYNOIC ACID Cyclohexylamine DL-PROPARGYL-GLY-OH BOC-(R)-ALPHA-PROPYNYL-PROLINE Carbamic acid, [(1R)-1-(hydroxymethyl)-2-propynyl]-, 1,1-dimethylethyl ester BOC-D-PRA-OH DCHA

  • (R)-(1-Hydroxymethyl-but-3-ynyl)-carbamic acid tert-butyl ester
  • (R)-2-tert-Butoxycarbonylamino-pent-4-ynoic acid
  • Boc-D-Propargylglycine.DCHA
  • (R)-N-BOC-PROPARGYLGLYCINE, 95%, 98% EE
  • (R)-N-BOC-Propargylglycine, 98% ee
  • (R)-N-BOC-Propargylglycine(R)-N-tert-Butoxycarbonyl-2-amino-4-pentynoic acid
  • (R)-N-TERT-BUTOXYCARBONYL-2-AMINO-4-PENTYNOIC
  • Boc-D-Propargylglycine ,98%
  • Boc-D-Propargylglycine Boc-D-Propargylglycine
  • Boc-D-propraglycine
  • (R)-2-Boc-AMino-4-pentynoic acid
  • Boc-(R)-2-Propargylglycine
  • Boc-D-Propargyl-Gly-OH
  • 2-[[4-[(2-methylpropan-2-yl)oxy]-4-oxobut-2-ynyl]amino]acetic acid
  • (2R)-2-{[(tert-butoxy)carbonyl]amino}pent-4-ynoic acid
  • D-2-Propargylglycine, N-BOC protected 97%
  • BOC-D-PROPARGYLGLYCINE
  • (R)-N-(TERT-BUTOXYCARBONYL)-PROPARGYLGLYCINE
  • (R)-N-TERT-BUTOXYCARBONYL-2-AMINO-4-PENTYNOIC ACID
  • (R)-N-BOC-PROPARGYLGLYCINE
  • RARECHEM BK PT 0259
  • Boc-D-Gly(propargyl)-OH
  • (R)-N-boc-Propargylglycine(e.e.)
  • N-TERT-BUTOXYCARBONYL-D-PROPARGYL GLYCINE
  • N-BOC-2-PROPARGYL-D-GLYCINE
  • BOC-2-PROPARGYL-D-GLYCINOL
  • D-2-Propargylglycine, N-BOC protected
  • (Tert-Butoxy)Carbonyl D-Pra-OH
  • Boc-D-Pra-OH Boc-D-Propargylglycine
  • 4-Pentynoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2R)-
  • N-Boc-2-propargyl-D-glycine,95%
  • (R)-N-BOC-Propargylglycine USP/EP/BP
  • (R)-N-Boc-2-propargyl-glycine
  • N-Boc-D-Propargylglycine
  • (R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid - [B90819]
  • 63039-46-3
  • Unusual amino acids
  • Amino Acids
  • Amino Acid Derivatives