6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine

Product Name: 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
CAS No.: 142217-80-9
Chemical Name: 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
Synonyms: ETB/N7;Ente-3;Entecavir-7;Entecavir E7;Entecavir Impurity 15;Entecavir Impurity 55;Entecavir interMediate 7;Entecavir InterMediate VII;[2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]Methanol;6-(Benzyloxy)-9-((1S,3R,3S)-4-(Benzyloxy)-3-(Benzyloxymethyl)?
CBNumber: CB01450899
Molecular Formula: C53H49N5O4
Formula Weight: 819.99
MOL File: 142217-80-9.mol

More

Less

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine Property

Density: 1.19
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.08±0.30(Predicted)
InChI: InChI=1S/C53H49N5O4/c1-38-46(36-60-33-39-18-8-3-9-19-39)48(61-34-40-20-10-4-11-21-40)32-47(38)58-37-54-49-50(58)55-52(56-51(49)62-35-41-22-12-5-13-23-41)57-53(42-24-14-6-15-25-42,43-26-16-7-17-27-43)44-28-30-45(59-2)31-29-44/h3-31,37,46-48H,1,32-36H2,2H3,(H,55,56,57)/t46-,47-,48-/m0/s1
InChIKey: OXHGMTPGAFKZHK-QQVWZEJNSA-N
SMILES: N1C2C(=NC(NC(C3=CC=C(OC)C=C3)(C3=CC=CC=C3)C3=CC=CC=C3)=NC=2OCC2=CC=CC=C2)N([C@H]2C[C@H](OCC3=CC=CC=C3)[C@@H](COCC3=CC=CC=C3)C2=C)C=1
CAS DataBase Reference: 142217-80-9(CAS DataBase Reference)

More

Less

Safety

HS Code: 29335990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H228Flammable solid
Precautionary statements: P403Store in a well-ventilated place.

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 090205
Product name: 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylene-cyclopenyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
Purity: 95+%
Packaging: 250mg
Price: $189
Updated: 2021/12/16

Matrix Scientific

Product number: 090205
Product name: 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylene-cyclopenyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
Purity: 95+%
Packaging: 1g
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0000821
Product name: 6-(BENZYLOXY)-9-((1S,3R,3S)-4-(BENZYLOXY)-3-(BENZYLOXYMETHYL)-2-METHYLENECYCLOPENTYL)-N-((4-METHOXYPHENYL)DIPHENYLMETHYL)-9H-PURIN-2-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $498.72
Updated: 2021/12/16

Matrix Scientific

Product number: 090205
Product name: 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylene-cyclopenyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine
Purity: 95+%
Packaging: 5g
Price: $1183
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 18907
Product name: Entecavirinter-3
Purity: >95%
Packaging: 5mg
Price: $2000
Updated: 2021/12/16

More

Less

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine Chemical Properties,Usage,Production

Chemical Properties

White powder

Definition

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine is also known as Entecavir Impurity 3. Entecavir belongs to the family of medicines called antivirals. Entecavir is used to treat liver infections caused by hepatitis B virus.

Synthesis

142217-79-6

142217-80-9

Step (1) Preparation of Intermediate IX: In a 20L sealed and nitrogen-filled reaction flask, 3.8kg of zinc powder and 10wt% hydrochloric acid (12.5L) were added sequentially and stirred at room temperature for 10-15 minutes, followed by diafiltration, and washed with purified water to neutral. Next, it was washed with 3.0 L of ethanol and 4.5 L of tetrahydrofuran and dried under vacuum at 40±2°C for 4-4.5 hours to obtain about 3 kg of activated zinc powder. The activated zinc powder needs to be sealed and stored under vacuum for backup. In a 100L reactor, after evacuation and replacement of nitrogen, add 40L of tetrahydrofuran dried by A-type molecular sieve. Under stirring, 3 kg of dry activated zinc powder and 1.3 L of dibromomethane were added, and the mixture was cooled to -70~-55°C. Then 1140 ml of titanium tetrachloride was added dropwise with continuous stirring for 1 hour. The temperature was then increased and the reaction was carried out for 48±0.5 h. The reaction was kept sealed during the reaction. The prepared enolization reagent was cooled to -20°C and a solution of 1.2 kg of Intermediate VIII dissolved in 20 L of dichloromethane was slowly added dropwise at -30°C. After the dropwise addition, the temperature was raised to 15-20 °C and the reaction was continued with stirring for 180 ± 10 min. The end point of the reaction was monitored by TLC. The reaction solution was transferred to a 200 L reaction vessel (containing a mixed system of 30 L of dichloromethane, 100 L of pure water and 10 kg of sodium bicarbonate) and stirred for 60-70 min. The mixture was separated using a stainless steel centrifuge and the filter cake was washed twice with dichloromethane (16L). The filtrates were combined and the aqueous phase was subjected to secondary extraction with dichloromethane (16L x 2). The combined organic phases were concentrated to dryness under vacuum at 25-30°C to afford 6-benzyloxy-9-((1S,3R,3S)-4-benzyloxy-3-benzyloxymethyl-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine (Intermediate IX) as a yellow powder in a single-step yield of 88% and purity of 93.6%.

References

[1] Patent: CN108148061, 2018, A. Location in patent: Paragraph 0028; 0029; 0030; 0031; 0032; 0033; 0034

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine Suppliers

China 165 India 4 United States 7 USA 1 Global 177

Zhejiang Warrant Pharmaceutical Co.,Ltd.

Tel: 0512-85180611 17312581805
Fax: 0512-89171181
Email: felix@lanxite.com
Country: China
ProdList: 6
Advantage: 55

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd

Tel: 13801208576
Fax: 010-64215766
Email: maggie@chinazhongshuo.com
Country: China
ProdList: 77
Advantage: 65

Xi'an Manareco New Materials Co., Ltd.

Tel: 029-68669089-8816
Fax: +86-29-68669073
Email: market@xarlm.com
Country: China
ProdList: 499
Advantage: 55

Tianjin Yao Technology Development Co., Ltd.

Tel: 022-18902014291 18902014291
Fax: 022-66211080
Email: byswxsb01@163.com
Country: China
ProdList: 101
Advantage: 58

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

Wuhan HengHeDa Pharm Co., Ltd.

Tel: 027-84888681 18086046872
Fax: 027-84888682
Email: hhdpharm@hotmail.com
Country: China
ProdList: 105
Advantage: 55

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

More

Less

View Lastest Price from 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine 142217-80-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Career Henan Chemical Co

Product: 6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine 142217-80-9
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-01

142217-80-9, 6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amineRelated Search:

Guaiacol Anisole (Trifluoromethoxy)benzene p-Anisaldehyde p-Anisidine 4-Methoxyphenol 4-Methoxybenzylchloride 4-Methoxybenzoic acid (1s-trans)-2-[(phenylmethoxy)methyl]-3-cyclopenten-1-ol (2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol (1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol 2-AMino-1,9-dihydro-9-[(1S,3R,4S)-4-(hydroxydiMethylsilyl)-3-(hydroxyMethyl)-2-Methylenecyclopentyl]-6H-purin-6-one Entecavir 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one (1'S,3'S,4'S)-Entecavir IsoMer (1R,3R,4R)-Entecavir (1S,3S,4R)-Entecavir Entecavir Impurity

6-(Benzyloxy)-9-(1S,3R,3S)-4-(benzyloxy)-3-(benzyoxymethyl)-2-methylenecyclopentyl)-N-N-(4-methyoxyphenyl)diaphenylmethyl)-9H-purin-2-amine

6-(benzyloxy)-9-(1S,3R,3S)-4-(benzyloxy)_3-(benzyoxymethyl)-2-methylenecyclopentyl)-N-N -(4-methyoxyphenyl)diaphenylmethyl)-9H-purin-2-amino

6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine

[1S-(1α,3α,4β)]-N-[(4-Methoxyphenyl)diphenyl-Methyl]-6-(phenylMethoxy)-9-[2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]-cyclopentyl]-9H-purin-2-aMine

Entecavir InterMediate VII

N-[(4-Methoxyphenyl)diphenylMethyl]-9-[(1S,3R,4S)-2-Methylene-4-(benzyloxy)-3-[(benzyloxy)Methyl]cyclopentyl]-6-(benzyloxy)-9H-Purin-2-aMine

Entecavir-7

Entecavir interMediate 7

6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine

N-[(4-methoxyphenyl)-diphenylmethyl]-9-[2-methylene-4-phenylmethoxy-3-(phenylmethoxymethyl)cyclopentyl]-6-phenylmethoxy-2-purinamine

6-(Benzyloxy)-9-((1S,3R,3S)-4-(Benzyloxy)-3-(Benzyloxymethyl)?

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)Methyl)-2-Methylenecyclopentyl)-N-((4-Methoxyphenyl)diphenylMethyl)-9H-purin-2-aMine

6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxyMethyl)-2-Methylenecyclopentyl)-N-((4-Methoxyphenyl)diphenylMethyl)-9H-purin-2-aMine (interMediate 6)

6-(Benzyloxy)-9-[(1R,3S,4R)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-N-[(4-methoxyphenyl)diphenylmethyl]-9H-purin-2-amine

[2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinyl]Methanol

6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxyMethyl)-2-Methylenecyclopentyl)-N-((4-Methoxyp

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylene-cyclopenyl)-N-((4-methox

9H-Purin-2-aMine,N-[(4-Methoxyphenyl)diphenylMethyl]-9-[(1S,3R,4S)-2-Methylene-4-(phenylMethoxy)-3-[(phenylMethoxy)Methyl]cyclopentyl]-6-(phenylMethoxy)-

Entecavir E7

6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-meth

N-[(4-Methoxyphenyl)diphenylmethyl]-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-6-(phenylmethoxy)-9H-purin-2-amine

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylene-cyclopenyl)-N-((4-met

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylene-cyclopenyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine

Entecavir Impurity 15

ETB/N7

N-[(4-methoxyphenyl)-diphenylmethyl]-9-[(1S,3S)-2-methylidene-4-phenylmethoxy-3-(phenylmethoxymethyl)cyclopentyl]-6-phenylmethoxypurin-2-amine

Entecavir Impurity 55

6-(benzyloxy)-9-[(1S,3R,4S)-4-(benzyloxy)-3-[(benzyloxy)methyl]-2-methylidenecyclopentyl]-N-[(4-methoxyphenyl)diphenylmethyl]-9H-purin-2-amine

6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-ami

6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine?(Ent-VII)

142217-80-9 6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine

Ente-3

6-(Benzyloxy)-9-((1S,3S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylenecyclopentyl)-N-((4-methoxyph

6-benzyloxy-9- ((1S, 3R, 3S) -4-benzyloxy-3-benzyloxymethyl-2-methylcyclopentyl) - N - ((4-methoxyphenyl) diphenylmethyl) -9H-purine-2-amine

N-[(4-Methoxyphenyl)diphenylmethyl]-9-[(1S,3R,4S)-2-methylene-4-(phenylmethoxy)-3-[(phenylmethoxy)me

142217-80-9

C53H49N5O4