Bazedoxifene

Product Name: Bazedoxifene
CAS No.: 198481-32-2
Chemical Name: Bazedoxifene
Synonyms: Tse-424;CS-1993;Batoxifene;Bazedoxifen;Bardoxifene;Bazedoxifene;Bazedoxifeno;Unii-Q16tt9C5bk;BAZEDOXIFENE BASE;Bazedoxifene [inn]
CBNumber: CB01458163
Molecular Formula: C30H34N2O3
Formula Weight: 470.6
MOL File: 198481-32-2.mol

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Bazedoxifene Property

Melting point:: 98-102°
Boiling point:: 694.4±55.0 °C(Predicted)
Density: 1.19
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 10.12±0.15(Predicted)
color: White to Very Dark Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B129245
Product name: Bazedoxifene
Packaging: 25mg
Price: $790
Updated: 2021/12/16

ApexBio Technology

Product number: A3232
Product name: Bazedoxifene
Packaging: 5mg
Price: $142
Updated: 2021/12/16

ApexBio Technology

Product number: A3232
Product name: Bazedoxifene
Packaging: 10mg
Price: $249
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0024680
Product name: BAZEDOXIFENE
Purity: 95.00%
Packaging: 5MG
Price: $502.94
Updated: 2021/12/16

Ambeed

Product number: A696565
Product name: Bazedoxifene
Purity: 98+%
Packaging: 5mg
Price: $109
Updated: 2021/12/16

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Bazedoxifene Chemical Properties,Usage,Production

Uses

Bazedoxifene is an nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene is used as an antiosteoporotic.

Definition

ChEBI: Bazedoxifene is a phenylindole.

General Description

Bazedoxifene, 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol (Viviant), was declared to be “approvable” bythe FDA in 2007 for the prevention of postmenopausalosteoporosis. As of mid-2009, final approval in the UnitedStates is still pending. Bazedoxifene was approved inEurope in 2009 for the treatment of post–menopausalosteoporosis.

Clinical Use

Bazedoxifene is an indole-based SERM that is under investigation for the treatment and prevention of postmenopausal osteoporosis. It also is being evaluated in combination with Premarin (conjugated estrogens). Bazedoxifene displaces 17β-estradiol from estrogen receptors and has excellent binding affinity for the receptor itself. Unlike raloxifene, this agent does not cause hot flashes at the doses required to have a beneficial effect on bone. In addition, it does not cause uterine or mammary gland stimulation.

Enzyme inhibitor

This potent and selective estrogen receptor modulator, or SERM (FW = 530.65 g/mol; CAS 198481-33-3; Solubility: 00 mM in DMSO), also named 1-[[4-[2- (hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2- (4- hydroxyphenyl) -3-methyl-1H-indol-5-ol, selectivity targets the extrogen receptor ERα (IC50 = 26 nM), with weaker action against ERβ (IC50 = 99 nM), inhibiting 17β-estradiol-induced proliferation of MCF-7 cells. Bazedoxifene represents a promising new treatment for osteoporosis, one with a potential for less uterine and vasomotor effects than selective estrogen receptor modulators now used clinically.

target

estrogen receptor

Bazedoxifene Preparation Products And Raw materials

Raw materials

Preparation Products

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Bazedoxifene Suppliers

Canada 1 China 99 India 9 United States 14 Global 123

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Alfa Chemistry

Tel
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 24072
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Santa Cruz Biotechnology, Inc.

Tel: --
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Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

W & J PharmaChem, Inc.

Tel: --
Fax: --
Email: info@wjpharmachem.com
Country: United States
ProdList: 595
Advantage: 50

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View Lastest Price from Bazedoxifene manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Bazedoxifene 198481-32-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 TONS
Release date: 2022-11-07

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Bazedoxifene 198481-32-2
Price: US $85.00-850.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-31

Career Henan Chemical Co

Product: Bazedoxifene 198481-32-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-09-18

198481-32-2, BazedoxifeneRelated Search:

FLAVOXATE Olaparib Indacaterol CETUXIMAB Baclofen VILAZODONE Rivaroxaban Liraglutide Capecitabine Sofosbuvir Dapoxetine 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol BAZEDOXIFENE ACETATE 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE 1-Ethyl-2-phenylindole Bazedoxifene 1-[4-(2-AZEPAN-1-YL-ETHOXY)-BENZYL]-5-BENZYLOXY-2-(4-BENZYLOXY-PHENYL)-3-METHYL-1H-INDOLE 1,3-DIMETHYL-2-PHENYLINDOLE

CS-1993

Batoxifene

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol

1-((4-(2-Hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol

1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-

Bazedoxifene

Bazedoxifene [inn]

Bazedoxifeno

Bazedoxifeno [inn-spanish]

Tse-424

Unii-Q16tt9C5bk

Bazedoxifen

BAZEDOXIFENE BASE

Bazedoxifene free base

1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphen...

1-(4-(2-(Azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol

Bardoxifene

198481-32-2

C30H34N2O3

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals