Canertinib

Product Name: Canertinib
CAS No.: 267243-28-7
Chemical Name: Canertinib
Synonyms: CS-152;PD-183805;Canetinib;Canertinib base;quinazolin-6-yl);CI-1033; PD-183805;CI-1033(Canertinib);Canertinib (CI-1033);Canertinib USP/EP/BP;-7-(3-morpholinopropoxy)
CBNumber: CB01458390
Molecular Formula: C24H25ClFN5O3
Formula Weight: 485.94
MOL File: 267243-28-7.mol

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Canertinib Property

Melting point:: 188-190°
Boiling point:: 691.0±55.0 °C(Predicted)
Density: 1.355±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥10.1 mg/mL in EtOH; ≥12.15 mg/mL in DMSO with gentle warming
form: Yellow powder.
pka: 12.09±0.43(Predicted)
color: Light yellow to yellow
CAS DataBase Reference: 267243-28-7

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C175600
Product name: Canertinib
Packaging: 10mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-0121
Product name: Canertinib
Purity: 98.02%
Packaging: 100mg
Price: $137
Updated: 2021/12/16

AK Scientific

Product number: Y0252
Product name: Canertinib
Packaging: 25mg
Price: $170
Updated: 2021/12/16

ApexBio Technology

Product number: A1845
Product name: Canertinib(CI-1033)
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: A1845
Product name: Canertinib(CI-1033)
Packaging: 10mM(in 1mL DMSO)
Price: $50
Updated: 2021/12/16

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Canertinib Chemical Properties,Usage,Production

Uses

CI-1033 is a potent inhibitor of EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.

Uses

Antineoplastic; irreversible pan-erbB tyrosine kinase inhibitor used to treat cancer.

Uses

Canertinib is a kind of irreversible pan-erbB tyrosine kinase inhibitor used to treat cancer.

Definition

ChEBI: A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a propenamido group at the 6-position, and a 3-morpholinopropoxy group at the 7-position.

Biological Activity

canertinib (also known as ci-1033), a 3-chloro, 4-fluoro, 4-anilinoquinazoline, is an orally available, potent and irreversible pan-erbb tyrosine kinase inhibitor that inhibits egfr, her2 and her4 in vitro with the half maximal inhibition concentration ic50 of 0.8 nm, 19 nm and 7 nm respectively [1].canertinib irreversibly binds into the atp pocket within the tk domain of all erbb family members, where the acrylamide side-chain at position c6 of canertinib is brought into close proximity with cysteines of erbb members, followed by the rapid formation of a covalent bond, which permanently inactivates the catalytically active erb1, erb2 and erb4 family members and effectively inhibits erbb3-dependent signaling [2].

References

[1] michelle arkin, mark m. moasser. her2 directed small molecule antagonists. curr opin investig drugs. author manuscript; available in pmc 2011 february 1. published in final edited form as: curr opin investig drugs. 2008 december; 9(12): 1264–1276.
[2] calvo e, tolcher aw, hammond la, patnaik a, de bono js, eiseman ia, olson sc, lenehan pf, mccreery h, lorusso p, rowinsky ek. administration of ci-1033, an irreversible pan-erbb tyrosine kinase inhibitor, is feasible on a 7-day on, 7-day off schedule: a phase i pharmacokinetic and food effect study. clin cancer res. 2004 nov 1;10(21):7112-20.

Canertinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Canertinib Suppliers

China 134 India 2 United Kingdom 2 United States 29 Global 167

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

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View Lastest Price from Canertinib manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Canertinib 267243-28-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

Dideu Industries Group Limited

Product: CANERTINIB
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: canertinib 267243-28-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

267243-28-7, CanertinibRelated Search:

AG 1478 HYDROCHLORIDE DAPH AG 18 LAVENDUSTIN A METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH AG 825 TYRPHOSTIN A25 PD 173074 Bortezomib Selumetinib GDC-0068 Erlotinib hydrochloride Olaparib AG 213 CIVENTICHEM CV-409 Canertinib dihydrochloride Canertinib

CS-152

CI-1033; PD-183805; CI1033; CI 1033; PD183805; PD 183805

CI-1033 (Canertinib, PD-183805)

CI-1033(Canertinib)

PD-183805

CI-1033; PD-183805

Canertinib base

Canetinib

Canertinib (CI-1033)

N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide

N-[4-(3-chloro-4-fluoro-anilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]acrylamide

N-[4-(3-chloro-4-fluoroanilino)-7-(3-Morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-en

2-PropenaMide,N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[3-(4-Morpholinyl)propoxy]-6-quinazolinyl]-

N-(4-(3-chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide

Canertinib N-[4-(3-Chloro-4-fluoroanilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]acrylamide

N-[4-(3-Chloro-4-fluoroanilino)-7-(3-morpholinopropoxy)quinazolin-6-yl]acrylamide Canertinib (CI-1033)

Canertinib--CI-1033, PD-183805

-7-(3-morpholinopropoxy)

N-(4-((3-Chloro-4-fluorophenyl)

quinazolin-6-yl)

Canertinib USP/EP/BP

ErbB-1,inhibit,Inhibitor,PD 183805,PD183805,Epidermal growth factor receptor,CI 1033,HER1,Orthopoxvirus,Canertinib,EGFR,CI1033

267243-28-7

C23H23ClFN5O3

Inhibitors