Tetraethyl ranelate
- Product Name
- Tetraethyl ranelate
- CAS No.
- 58194-26-6
- Chemical Name
- Tetraethyl ranelate
- Synonyms
- 10G/50G/5KGS;TETRAETHYL RANELATE;)-5-(ethoxycarbonyL;INTERMEDIATE:STRONTIUMRANELATE;TETRAETHYL RANELATE 58194-26-6;Intermediate of Strontium ranelate;2,2'-((3-cyano-4-(2-ethoxy-2-oxoethyL;Tetraethyl ranelate ISO 9001：2015 REACH;Diethyl 2,2'-((3-cyano-4-(2-ethoxy-2-oxoethyl)-5-(ethoxycarbonyl)thiophen-2-yl)azanediyl)diace;5-[Bis(2-ethoxy-2-oxoethyl)amino]-4-cyano-2-(ethoxycarbonyl)-3-thiopheneacetic acid ethyl ester
- CBNumber
- CB01461228
- Molecular Formula
- C20H26N2O8S
- Formula Weight
- 454.49
- MOL File
- 58194-26-6.mol
Tetraethyl ranelate Property
- Melting point:
- 103-106 °C
- Boiling point:
- 579.2±50.0 °C(Predicted)
- Density
- 1.28
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- -3.75±0.50(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T204555
- Product name
- TetraethylRanelate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B525
- Product name
- Tetraethylranelate
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- 089950
- Product name
- Diethyl 2,2'-((3-cyano-4-(2-ethoxy-2-oxoethyl)-5-(ethoxycarbonyl)thiophen-2-yl)azanediyl)diacetate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $567
- Updated
- 2021/12/16
- Product number
- 089950
- Product name
- Diethyl 2,2'-((3-cyano-4-(2-ethoxy-2-oxoethyl)-5-(ethoxycarbonyl)thiophen-2-yl)azanediyl)diacetate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- CHM0094734
- Product name
- 2-[N,N-DI(ETHOXYCARBONYLMETHYL)AMINO]-3-CYANO-4-ETHOXYCARBONYLMETHYLTHIOPHENE-5-CARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1KG
- Price
- $7907.13
- Updated
- 2021/12/16
Tetraethyl ranelate Chemical Properties,Usage,Production
Synthesis
58168-20-0
105-36-2
58194-26-6
(1) In a 20 liter autoclave, 1 kg ethyl 5-amino-4-cyano-3-(2-ethoxy-2-carboxymethyl)-2-thiophenecarboxylate, 12 liters of tetrahydrofuran, 1.92 kg potassium carbonate, 2.3 kg ethyl bromoacetate, and 20 grams of crown ether were added and heated to reflux, and the progress of the reaction was monitored by high-performance liquid chromatography (HPLC) (Fig. 9 shows the end of the reaction by HPLC). control plot), the reaction took about 3-4 hours to complete. After completion of the reaction, the mixture was filtered and the filtrate was concentrated by distillation under reduced pressure. Subsequently, 4 liters of ethanol were added and pulped under ice bath conditions for 3-4 hours and filtered again. The filter cake was washed with ice ethanol and finally dried in an oven at 45°C to obtain 1.25 kg of ethyl 5-[bis(2-ethoxy-2-carboxymethyl)amino-]-4-cyano-3-(2-ethoxy-2-carboxymethyl)-2-thiophene carboxylate in 91% yield and 99.86% purity.
References
[1] Patent: CN103804345, 2017, B. Location in patent: Paragraph 0044; 0047; 0050
[2] Heteroatom Chemistry, 2007, vol. 18, # 3, p. 236 - 238
[3] Patent: WO2011/124992, 2011, A1. Location in patent: Page/Page column 19-20
Tetraethyl ranelate Preparation Products And Raw materials
Raw materials
Preparation Products
Tetraethyl ranelate Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
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View Lastest Price from Tetraethyl ranelate manufacturers
- Product
- Tetraethyl ranelate 58194-26-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- Tetraethyl ranelate 58194-26-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-14