Canrenone

Product Name: Canrenone
CAS No.: 976-71-6
Chemical Name: Canrenone
Synonyms: CANRENONE-D4;sc9376;11614r.p;RP-11614;CANRENONE;phanurane;kanlitong;ALDADIENE;NSC 261713;Canrenone CRS
CBNumber: CB0147626
Molecular Formula: C22H28O3
Formula Weight: 340.46
MOL File: 976-71-6.mol

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Canrenone Property

Melting point:: 158-1600C
alpha: D +24.5° (chloroform)
Boiling point:: 416.25°C (rough estimate)
Density: 1.1236 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: room temp
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige
optical activity: [α]/D +17 to +24°, c = 1 in chloroform-d
Water Solubility: 272.4ug/L(25 ºC)
InChI: InChI=1/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/s3
InChIKey: UJVLDDZCTMKXJK-MUWITHSMNA-N
SMILES: [C@@]12(CCC(=O)O1)CC[C@@]1([H])[C@]3([H])C=CC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]21C |&1:0,8,10,20,22,26,r|
LogP: 2.54 at 25℃
CAS DataBase Reference: 976-71-6
NIST Chemistry Reference: Canrenone(976-71-6)

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Safety

Hazard Codes: Xn,N
Risk Statements: 40-51/53
Safety Statements: 36/37-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1497
Product name: Canrenone
Purity: ≥97% (HPLC)
Packaging: 50mg
Price: $80.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2887
Product name: Spironolactone Related Compound A
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 150MG
Price: $344
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1619017
Product name: Spironolactone Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $1490
Updated: 2024/03/01

Alfa Aesar

Product number: J60238
Product name: Canrenone, 98%
Packaging: 1g
Price: $59.65
Updated: 2024/03/01

Alfa Aesar

Product number: J60238
Product name: Canrenone, 98%
Packaging: 5g
Price: $187.65
Updated: 2024/03/01

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Canrenone Chemical Properties,Usage,Production

Chemical Properties

Pale yellow to pale Green Solid

Originator

Spiroctan,Boehringer Mannheim,Switz.,1968

Uses

Aldosterone antagonist. Diuretic

Uses

antiinflammatory, glucocorticoid

Uses

Inhibits aldosterone biosynthesis and blocks ouabain effects

Definition

ChEBI: Canrenone is a steroid lactone.

Manufacturing Process

The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl- 17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling point of the solvent under reflux overnight. The solution is then cooled and filtered through approximately 200 parts of silica gel. The gel is successively washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the washings comprising 15% ethyl acetate are thereupon purified by chromatography on a further quantity of silica gel, using benzene and ethyl acetate as developing solvents. From the 15% ethyl acetate eluate there is obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone, melting at 148° to 151°C. The product solidifies above this melting point and melts again at 165°C.

brand name

Luvion.

Therapeutic Function

Aldosterone antagonist, Diuretic

World Health Organization (WHO)

Canrenone, which has aldosterone antagonist activity, is a major metabolite of spironolactone and the major metabolite of potassium canrenoate. See WHO comments for potassium canrenoate and spironolactone.

Flammability and Explosibility

Non flammable

Biological Activity

Mineralocorticoid receptor antagonist. Active metabolite of spironolactone ((7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone ).

Biochem/physiol Actions

Canrenone is a mineralocorticoid (aldosterone) inhibitor.

Canrenone Preparation Products And Raw materials

Raw materials

Potassium Propionate Androstenediol Iodomethane

Preparation Products

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Canrenone Suppliers

Canada 3 China 203 France 1 Germany 3 India 8 Spain 2 United Kingdom 9 United States 26 Venezuela 1 Global 256

Hubei Qibu New Material Technology Co., Ltd.

Tel: 0715-8890696 18062324989 18062324989
Email: 2284979616@qq.com
Country: China
ProdList: 519
Advantage: 58

HuBei ShengBaoLai Biological Technology Co., Ltd

Tel: 027-027-59105235 13007105135
Fax: 027-59105235
Email: sbl1120@163.com
Country: China
ProdList: 106
Advantage: 55

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2341
Advantage: 56

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 0712-0712-2580635 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8849
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Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11714
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Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
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View Lastest Price from Canrenone manufacturers

Hebei Kangcang new material Technology Co., LTD

Product: Canrenone 976-71-6
Price: US $20.00-10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20
Release date: 2024-03-20

Hebei Kangcang new material Technology Co., LTD

Product: Canrenone 976-71-6
Price: US $9.00-60.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-03-22

hebei hongtan Biotechnology Co., Ltd

Product: Canrenone 976-71-6
Price: US $30.00/box
Min. Order: 1box
Purity: 98%
Supply Ability: 2000box
Release date: 2024-03-21

976-71-6, CanrenoneRelated Search:

11-HYDROXY-CANRENONE Coenzyme Q10 Risperidone CHLOROPHOSPHONAZO III (-)-Corey lactone diol TRIOXSALEN 11-a-Hydroxy canrenone methyl ester Delta 9,11-canrenone (7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester 6-B-HYDROXY EPLERENONE Eplerenone EP Impurity B SC 25152 Eplerenone EP Impurity A Eplerenone 7-Carboxylic Acid Impurity Undecan-4-olide DIHYDROTERPINYL ACETATE gamma-Octanoic lactone Dihydrojasmone lactone

phanurane

pregna-4,6-diene-21-carboxylicacid,17-hydroxy-3-oxo-,gamma-lactone,(17-alph

sc9376

spirolactonesc14266

CANRENOIC ACID GAMMA LACTONE

CANRENONE

CANRENONE-D4

4,6-ANDROSTADIEN[(17(B-1')-SPIRO-5')]-PERHYDROFURAN-2,3-DIONE

4,6-ANDROSTEN-17-ALPHA-YL-PROPIONIOACID-R-LACTONE

PREGNA-4,6-DIENE-17-BETA-0L-3-ONE-21-CARBOXYLIC ACID-GAMMA LACTONE

7-Carboxy-9(11)&Delta

kanlitong

Spironolactone Impurity 6（Spironolactone EP Impurity F）

11614r.p

17-(2-Carboxyethyl)17-hydroxy-3-oxoandrosta-4,6-dienelactone

17-(2-Carboxyethyl)17-hydroxyandrosta-4,6-dien-3-onelactone

17-hydroxy-3-oxo-,gamma-lactone,(17-alpha)-pregna-6-diene-21-carboxylicacid

17-Hydroxy-3-oxo-17-pregna-4,6-diene-21-carboxylicacid-lactone

ALDADIENE

17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone

CANRENONE[SPIRONOLACTONE INTERMEDIATE]

Canrenone98.5%Min

17a-(2-Carboxyethyl-17b-hydroxyandrosta-4,6-dien-3-one Lactone

(7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid g-Lactone

((7 )-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid -Lactone)

(7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid -Lactone

17a-2-Carboxyethyl-17-hydroxyandrosta-4,6-dien-3-one Lactone

Spironolactone EP Impurity F

Journal of risperidone

Canrenone, >=97%

Eplerenone Impurity 28

(17R)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone

(17R)-3-Oxo-17-hydroxypregna-4,6-diene-21-carboxylic acid γ-lactone

(17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylicacidγ-lactone

Spironolactone Related Compound A (100 mg) (Canrenone (3-Oxo-17-alpha-pregna-4,6-diene-21, 17-carbolactone)) (AS)

Eplerenone IMpurity - Canrenone

(8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione

Spironolactone Related CoMpound A

Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, g-lactone, (17a)-

Canrenone 17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone

NSC 261713

10,13-Dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione

Canrenone Solution, 100ppm

Eplerenone Canrenone Impurity

Canrenone CRS

6,7-Dehydro-7α-desthioacetylspironolactone

RP-11614

Spironolactone EP Impurity F-d4 (Canrenone-d4)

Spironolactone EP Impurity F (Canrenone)

Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, (17α)-

7-Carboxy-9(11)Δ-canrenone

Spiranolactone Impurity F

Canrenone D7Q: What is Canrenone D7 Q: What is the CAS Number of Canrenone D7 Q: What is the storage condition of Canrenone D7 Q: What are the applications of Canrenone D7

CanrenoneQ: What is Canrenone Q: What is the CAS Number of Canrenone Q: What is the storage condition of Canrenone Q: What are the applications of Canrenone

Spironolactone Related Compound A (Canrenone (3-Oxo-17-alpha-pregna-4,6-diene-21, 17-carbolactone)) (1619017)

Candy, ketone

6,7-Dehydro-7α-desthioacetylspironolactone

Spironolactone USP Related Compound A