EZ-LINK (TM) PFP-BIOTIN, 50 MG
- Product Name
- EZ-LINK (TM) PFP-BIOTIN, 50 MG
- CAS No.
- 120550-35-8
- Chemical Name
- EZ-LINK (TM) PFP-BIOTIN, 50 MG
- Synonyms
- Biotin-PFP;Biotin-opfp;Biotinyl-OPfp;CAS_120550-35-8;Biotin-PFP ester;(+)-Biotin-PFP-ester;EZ-LINK (TM) PFP-BIOTIN;EZ-LINK (TM) PFP-BIOTIN, 50 MG;Biotin pentafluorophenyl ester;Biotin-PFP Biotin pentafluorophenyl ester
- CBNumber
- CB01477379
- Molecular Formula
- C16H15F5N2O3S
- Formula Weight
- 410.36
- MOL File
- 120550-35-8.mol
EZ-LINK (TM) PFP-BIOTIN, 50 MG Property
- Melting point:
- 190.0 to 194.0 °C
- Boiling point:
- 555.3±50.0 °C(Predicted)
- Density
- 1.441
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- powder to crystal
- pka
- 13.89±0.40(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C16H15F5N2O3S/c17-9-10(18)12(20)15(13(21)11(9)19)26-8(24)4-2-1-3-7-14-6(5-27-7)22-16(25)23-14/h6-7,14H,1-5H2,(H2,22,23,25)/t6-,7-,14-/m0/s1
- InChIKey
- DKTMDBQDSYQUEV-LEJLMFORSA-N
- SMILES
- C1(=O)N[C@]2([H])[C@H](CCCCC(OC3=C(F)C(F)=C(F)C(F)=C3F)=O)SC[C@]2([H])N1
- CAS DataBase Reference
- 120550-35-8
Safety
- HS Code
- 2934.99.9001
N-Bromosuccinimide Price
- Product number
- B3173
- Product name
- Biotin Pentafluorophenyl Ester
- Purity
- >97.0%(HPLC)
- Packaging
- 50mg
- Price
- $92
- Updated
- 2025/07/31
- Product number
- B3173
- Product name
- Biotin Pentafluorophenyl Ester
- Purity
- >97.0%(HPLC)
- Packaging
- 250mg
- Price
- $278
- Updated
- 2025/07/31
- Product number
- CDX-B0308-M250
- Product name
- (+)-Biotin-PFP-ester
- Purity
- ≥98%(HPLC)
- Packaging
- 250mg
- Price
- $282
- Updated
- 2021/12/16
- Product number
- FB52762
- Product name
- (+)-Biotin-PFP-ester
- Packaging
- 500mg
- Price
- $335
- Updated
- 2021/12/16
- Product number
- Z5617
- Product name
- (+)-Biotin-PFP-ester
- Packaging
- 250mg
- Price
- $342
- Updated
- 2021/12/16
EZ-LINK (TM) PFP-BIOTIN, 50 MG Chemical Properties,Usage,Production
Description
Biotin-PFP ester will react with primary amino groups (-NH2) to form stable, irreversible amide bonds.
Uses
(+)-Biotin-PFP-ester is used to prepare melampomagnolide B as an antileukemic sesquiterpene.
Synthesis
771-61-9
58-85-5
120550-35-8
GENERAL STEPS: D-Biotin (2.95 g, 12.00 mmol) was dissolved in N,N-dimethylformamide (DMF, 10 mL) to which pentafluorophenol (Pfp-OH, 2.80 g, 15.20 mmol) was subsequently added. A DMF solution (15 mL) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC-HCl, 5.70 g, 29.70 mmol) was slowly added dropwise to the above mixture over 30 min at 0 °C. After the dropwise addition, the reaction mixture was stirred overnight at room temperature under nitrogen atmosphere. Upon completion of the reaction, the product was washed with dichloromethane (DCM) to afford the target compound 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid perfluorophenyl ester in white powder form in 90% yield (4.50 g). The obtained product can be directly used in the subsequent reaction without further purification.1H NMR (D2O) data were as follows: δ 1.41-1.69 (m, 6H, CH2), 2.57 (d, 1H, CH2), 2.77-2.85 (m, 3H, CH2), 3.11-3.12 (m, 1H, CH), 4.14 (t, 1H, CH), 4.30 (t, 1H, CH), 6.37 (d, 2H, NH).
IC 50
Alkyl/ether
References
[1] Synthetic Communications, 1996, vol. 26, # 13, p. 2531 - 2547
[2] Journal of the American Chemical Society, 2009, vol. 131, p. 7954 - 7955
[3] Russian Journal of Bioorganic Chemistry, 1994, vol. 20, # 8-9, p. 520 - 528
[4] Bioorganicheskaya Khimiya, 1994, vol. 20, # 8-9, p. 955 - 966
[5] Organic and biomolecular chemistry, 2003, vol. 1, # 6, p. 950 - 959
EZ-LINK (TM) PFP-BIOTIN, 50 MG Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from EZ-LINK (TM) PFP-BIOTIN, 50 MG manufacturers
- Product
- Biotin-PFP 120550-35-8
- Price
- US $0.00/mg
- Min. Order
- 250mg
- Purity
- >95.00%
- Supply Ability
- 25g
- Release date
- 2024-03-30
- Product
- EZ-LINK (TM) PFP-BIOTIN, 50 MG 120550-35-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- EZ-LINK (TM) PFP-BIOTIN, 50 MG 120550-35-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08