Biotin-PEG2-C4-Alkyne

Product Name: Biotin-PEG2-C4-Alkyne
CAS No.: 1011268-28-2
Chemical Name: Biotin-PEG2-C4-Alkyne
Synonyms: Biotin-PEG2-C4-Alkyne;1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[2-[2-[2-[(1-oxo-5-hexyn-1-yl)amino]ethoxy]ethoxy]ethyl]-, (3aS,4S,6aR)-
CBNumber: CB73062389
Molecular Formula: C22H36N4O5S
Formula Weight: 468.61
MOL File: 1011268-28-2.mol

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Biotin-PEG2-C4-Alkyne Property

Boiling point:: 799.8±60.0 °C(Predicted)
Density: 1.158±0.06 g/cm3(Predicted)
solubility: Soluble in DMSO, DMF
form: A crystalline solid
pka: 13.90±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13038
Product name: Alkynyl-biotin
Purity: ≥95%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 13038
Product name: Alkynyl-biotin
Purity: ≥95%
Packaging: 5mg
Price: $365
Updated: 2024/03/01

Cayman Chemical

Product number: 13038
Product name: Alkynyl-biotin
Purity: ≥95%
Packaging: 10mg
Price: $638
Updated: 2024/03/01

BroadPharm

Product number: BP-22693
Product name: Biotin-PEG2-C4-alkyne
Purity: 98%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

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Biotin-PEG2-C4-Alkyne Chemical Properties,Usage,Production

Description

Alkynyl-biotin is a form of biotin with a terminal alkyne group separated by two polyethylene glycol moieties. It is used to add biotin to other molecules bearing an azide group using a copper Cu(I)-catalyzed azide-alkyne cycloaddition reaction. Alkynyl-biotin has been used to add a biotin tag to a range of biochemicals, amino acids, proteins, and nucleotides that have been modified by the addition of an azide group. Alkynyl-biotin can also be used to capture sulfenic acid-modified proteins that have been tagged with the cell-permeable probe DAz-2 .

Uses

Biotin-PEG2-C4-alkyne is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG2-C4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] DANIEL B. MCCLATCHY, *. Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice[J]. Journal of Proteome Research, 2015, 14 11: 4815-4822. DOI: 10.1021/acs.jproteome.5b00653
[2] PENG WU. A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins[J]. Acta Pharmacologica Sinica, 2016, 37 10: 1307-1314. DOI: 10.1038/aps.2016.31
[3] JESSICA ZAYAS. Strain Promoted Click Chemistry of 2- or 8-Azidopurine and 5-Azidopyrimidine Nucleosides and 8-Azidoadenosine Triphosphate with Cyclooctynes. Application to Living Cell Fluorescent Imaging[J]. Bioconjugate Chemistry Bioconjugate, 2015, 26 8: 1519-1532. DOI: 10.1021/acs.bioconjchem.5b00300
[4] STEPHEN E. LEONARD Kate S C Khalilah G Reddie. Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells[J]. ACS Chemical Biology, 2009, 4 9: 783-799. DOI: 10.1021/cb900105q

Biotin-PEG2-C4-Alkyne Preparation Products And Raw materials

Raw materials

Preparation Products

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Biotin-PEG2-C4-Alkyne Suppliers

China 28 United States 5 Global 33

Sichuan Wei Keqi Biological Technology Co., Ltd.

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Hangzhou Taorui Biotechnology Co., Ltd

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Zhengzhou Akem Chemical Co., Ltd

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View Lastest Price from Biotin-PEG2-C4-Alkyne manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Biotin-PEG2-C4-alkyne 1011268-28-2
Price: US $0.00/mg
Min. Order: 10mg
Purity: >95.00%
Supply Ability: 10mg
Release date: 2024-03-21

1011268-28-2, Biotin-PEG2-C4-AlkyneRelated Search:

UV Cleavable Biotin-PEG2-Azide Biotin-PEG4-Methyltetrazine Acetylene-PEG4-biotin conjugate Biotin-PEG2-azide Biotin-PEG4-N3 Biotin-PEG<sub>4</sub>-Azide DBCO-PEG4-biotin 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-2-oxo-N-2-propynyl-, (3aS,4S,6aR)- Azide-SS-biotin (4E)-TCO-PEG4-biotin Biotin-PEG4- Picolyl Azide EZ-LINK (TM) PFP-BIOTIN, 50 MG (3aS,4S,6aR)-Hexahydro-2-oxo-N-(15-oxo-3,6,9,12-tetraoxa-16-azanonadec-18-yn-1-yl)-1H-thieno[3,4-d]imidazole-4-pentanamide Mal-PEG3-Mal Biotin-PEG2-C6-Azide 1H-Thieno[3,4-d]iMidazole-4-pentanaMide, hexahydro-N-[2-(2-hydroxyethoxy)ethyl]-2-oxo-, (3aS,4S,6aR)- Biotin-PEG2-Hydrazide Biotin-PEG2-SH

Biotin-PEG2-C4-Alkyne

1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[2-[2-[2-[(1-oxo-5-hexyn-1-yl)amino]ethoxy]ethoxy]ethyl]-, (3aS,4S,6aR)-

1011268-28-2