Azide-SS-biotin
- Product Name
- Azide-SS-biotin
- CAS No.
- 1620523-64-9
- Chemical Name
- Azide-SS-biotin
- Synonyms
- Biotin-SS-azide;Azide-SS-biotin;Azide-C2-SS-C2-biotin;Biotin-SS-azide,Azide-SS-biotin;5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-{2-[(2-azidoethyl)disulfanyl]ethyl}pentanamide;N-(2-((2-azidoethyl)disulfaneyl)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
- CBNumber
- CB63363861
- Molecular Formula
- C14H24N6O2S3
- Formula Weight
- 404.57
- MOL File
- 1620523-64-9.mol
Azide-SS-biotin Property
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- BP-22877
- Product name
- Azide-SS-biotin
- Purity
- 98%
- Packaging
- 250mg
- Price
- $950
- Updated
- 2021/12/16
Azide-SS-biotin Chemical Properties,Usage,Production
Description
Azide-SS-biotin is a cleavable biotinylation reagent for labeling alkyne-containing biomolecules using click chemistry. The azide group reacts with alkynes, DBCO or BCN reagent to form a stable triazole linkage. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP.
Uses
Azide-C2-SS-C2-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azide-C2-SS-C2-biotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
Disulfide Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
Azide-SS-biotin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azide-SS-biotin manufacturers
- Product
- Biotin-SS-azide 1620523-64-9
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >98.00%
- Supply Ability
- 100mg
- Release date
- 2024-03-21