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Biotin-PEG<sub>4</sub>-Azide

Product Name
Biotin-PEG<sub>4</sub>-Azide
CAS No.
1309649-57-7
Chemical Name
Biotin-PEG<sub>4</sub>-Azide
Synonyms
(+)-Biotin-PEG4-CH2CH2N3;Biotin-PEG4-Azide;Biotin-PEG4-azide,Biotin-PEG4-N3;N-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl]biotinamide;N-(14-Azido-3,6,9,12-tetraoxatetradecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide;Biotin-PEG4-CH2CH2N3/1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(14-azido-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)-
CBNumber
CB73166962
Molecular Formula
C20H36N6O6S
Formula Weight
488.60144
MOL File
1309649-57-7.mol
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Biotin-PEG<sub>4</sub>-Azide Property

Melting point:
102.0 to 106.0 °C
storage temp. 
-20°C, sealed storage, away from moisture
form 
powder to lump
color 
White to Light yellow
InChIKey
PVEHVEYAPUNCCP-LLFBLNAENA-N
SMILES
C(NCCOCCOCCOCCOCCN=[N+]=[N-])(=O)CCCC[C@H]1[C@@]2([H])NC(=O)N[C@@]2([H])CS1 |&1:24,25,31,r|
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Safety

HS Code 
2934.99.9001
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical
Product number
B6266
Product name
Biotin-PEG4-Azide (2mg×5)
Packaging
1SET
Price
$158
Updated
2025/07/31
TCI Chemical
Product number
B5546
Product name
Biotin-PEG4-Azide
Purity
>96.0%(HPLC)
Packaging
100mg
Price
$428
Updated
2025/07/31
AK Scientific
Product number
J96951
Product name
Biotin-PEG4-azide
Packaging
25mg
Price
$64
Updated
2021/12/16
BroadPharm
Product number
BP-22119
Product name
Biotin-PEG4-azide
Purity
98%
Packaging
100mg
Price
$280
Updated
2021/12/16
Chem-Impex
Product number
37489
Product name
Biotin-PEG4-azide,96%(HPLC)
Purity
96%(HPLC)
Packaging
100MG
Price
$499.52
Updated
2021/12/16
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Biotin-PEG<sub>4</sub>-Azide Chemical Properties,Usage,Production

Description

Biotin-PEG4-azide is a very useful biotinylation reagent that enable Click Chemistry reaction with alkyne, such as Propargyl, DBCO or BCN reagent to form a stable bond. PEG4 spacer increases aqueous solubility of the molecules conjugated to the biotin. It also helps to minimize steric hindrance involved with the binding to avidin molecules.

Uses

Biotin-PEG4-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329

Biotin-PEG<sub>4</sub>-Azide Preparation Products And Raw materials

Raw materials

Preparation Products

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Biotin-PEG<sub>4</sub>-Azide Suppliers

Americas 1 China 65 Europe 1 India 1 Japan 1 United States 6 Global 75
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
Tel
13892832556
Email
2440688701@qq.com
Country
China
ProdList
1994
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58
Suzhou Derivative Biotechnology Co., Ltd.
Tel
13915541704
Email
2436368162@qq.com
Country
China
ProdList
554
Advantage
58
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ChemPep, Inc.
Tel
+1 (888) 615-9178 / (561) 791-8787
Fax
+1 (561) 791-8728
Email
service@chempep.com
Country
United States
ProdList
2138
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
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View Lastest Price from Biotin-PEG<sub>4</sub>-Azide manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Biotin-PEG4-azide 1309649-57-7
Price
US $0.00/mg
Min. Order
100mg
Purity
>98.00%
Supply Ability
100mg
Release date
2024-03-22

1309649-57-7, Biotin-PEG<sub>4</sub>-AzideRelated Search:

Azide-SS-biotin Biotin-PEG4- Picolyl Azide EZ-LINK (TM) PFP-BIOTIN, 50 MG Biotin-PEG6-OH 15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester Biotin-PEG3-propionic hydrazide 9-biotinlaMino-4,7-dioxanonanoic acid N-hydroxysucciniMidyl ester 15-[D(+)-BIOTINYLAMINO]-4,7,10,13-TETRAOXAPENTADECANOIC ACID Biotin-PEG3-propionic acid Biotin-PEG5-Amine N-BIOTINYL-3,6-DIOXAOCTANE-1,8-DIAMINE 1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-,(3aS,4S,6aR)- Biotin-PEG4-N3 N-Biotinyl-N'-(3-maleimidopropionyl)-3,6-dioxaoctane-1,8-diamine Biotin-PEG3-N3 Biotin-PEG5-azide Biotin-PEG4-Amide-C6-Azide Biotin-PEG4-Mal

  • N-(14-Azido-3,6,9,12-tetraoxatetradecyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
  • (+)-Biotin-PEG4-CH2CH2N3
  • Biotin-PEG4-azide,Biotin-PEG4-N3
  • N-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl]biotinamide
  • Biotin-PEG4-CH2CH2N3/1H-Thieno[3,4-d]imidazole-4-pentanamide, N-(14-azido-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-, (3aS,4S,6aR)-
  • Biotin-PEG<sub>4</sub>-Azide
  • 1309649-57-7
  • C20H36N6O6S
  • peg