Biotin-PEG4- Picolyl Azide
- Product Name
- Biotin-PEG4- Picolyl Azide
- CAS No.
- 2222687-71-8
- Chemical Name
- Biotin-PEG4- Picolyl Azide
- Synonyms
- Biotin-PEG4- Picolyl Azide
- CBNumber
- CB23363878
- Molecular Formula
- C27H42N8O7S
- Formula Weight
- 622.74
- MOL File
- 2222687-71-8.mol
Biotin-PEG4- Picolyl Azide Property
- storage temp.
- Storage temp. 2-8°C
- form
- Oil
- color
- Colorless to off-white
N-Bromosuccinimide Price
- Product number
- BP-22954
- Product name
- Biotin-PEG4-Picolylazide
- Purity
- 95%
- Packaging
- 5mg
- Price
- $129
- Updated
- 2021/12/16
- Product number
- PEG8000
- Product name
- Biotin-PEG(4)-Picolyl-N3
- Packaging
- 5mg
- Price
- $263.25
- Updated
- 2021/12/16
- Product number
- PEG8000
- Product name
- Biotin-PEG(4)-Picolyl-N3
- Packaging
- 25mg
- Price
- $506.25
- Updated
- 2021/12/16
- Product number
- PEG8000
- Product name
- Biotin-PEG(4)-Picolyl-N3
- Packaging
- 100mg
- Price
- $1383.75
- Updated
- 2021/12/16
Biotin-PEG4- Picolyl Azide Chemical Properties,Usage,Production
Description
Biotin-PEG4-Picolyl azide is a biotin reagent which can be conjugated with alkyne-containing biomolecules. This biotin reagent incorporates a copper-chelating motif that dramatically accelerates the Cu(I)-catalyzed Click Chemistry. The use of Biotin Picolyl Azide instead of conventional Biotin Azide allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling. The hydrophilic spacer arm provides better solubility to the labeled molecules in aqueous media.
Uses
Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-Picolyl azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Biotin-PEG4- Picolyl Azide Preparation Products And Raw materials
Raw materials
Preparation Products
Biotin-PEG4- Picolyl Azide Suppliers
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View Lastest Price from Biotin-PEG4- Picolyl Azide manufacturers
- Product
- Biotin-PEG4-Picolyl-azide 2222687-71-8
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- >98.00%
- Supply Ability
- 5mg
- Release date
- 2024-03-22