ChemicalBook > CAS DataBase List > 6-(1H-Pyrazol-1-yl)nicotinic acid

6-(1H-Pyrazol-1-yl)nicotinic acid

Product Name
6-(1H-Pyrazol-1-yl)nicotinic acid
CAS No.
253315-22-9
Chemical Name
6-(1H-Pyrazol-1-yl)nicotinic acid
Synonyms
CAS:253315-22-9;6-(1-Pyrazolyl)nicotinic Acid;6-Pyrazol-1-yl-nicotinic acid;6-(1H-Pyrazol-1-yl)nicotinic acid;6-(1H-Pyrazol-1-yl)nicotinic acid ,97%;6-pyrazol-1-ylpyridine-3-carboxylic acid;6-(1H-Pyrazol-1-yl)pyridine-3-carboxylic acid;6-(1H-Pyrazol-1-yl)-pyridin-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-(1H-pyrazol-1-yl)-
CBNumber
CB01481996
Molecular Formula
C9H7N3O2
Formula Weight
189.17
MOL File
253315-22-9.mol
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6-(1H-Pyrazol-1-yl)nicotinic acid Property

Melting point:
272-274℃
Boiling point:
394.6±27.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
3.28±0.10(Predicted)
color 
White to off-white
CAS DataBase Reference
253315-22-9
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Apolloscientific
Product number
OR938164
Product name
6-(1H-Pyrazol-1-yl)nicotinicacid
Purity
97%
Packaging
1g
Price
$105
Updated
2021/12/16
AK Scientific
Product number
Z3007
Product name
6-(1H-Pyrazol-1-yl)nicotinicacid
Packaging
1g
Price
$139
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK104641
Product name
6-(1H-Pyrazol-1-yl)nicotinicacid
Purity
97%
Packaging
1g
Price
$153
Updated
2021/12/16
Apolloscientific
Product number
OR938164
Product name
6-(1H-Pyrazol-1-yl)nicotinicacid
Purity
97%
Packaging
5g
Price
$235
Updated
2021/12/16
Matrix Scientific
Product number
033160
Product name
6-(1H-Pyrazol-1-yl)nicotinic acid
Packaging
500mg
Price
$246
Updated
2021/12/16
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6-(1H-Pyrazol-1-yl)nicotinic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

1428929-49-0

253315-22-9

Compound 1 (CAS: 1428929-49-0, 8.66 g, 40.43 mmol, 1.0 eq.) was dissolved in anhydrous ethanol (80 mL), followed by slow addition of 3 M aqueous sodium hydroxide solution (40.40 mL, 121.3 mmol, 3.0 eq.). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the solvent was removed by reduced pressure distillation and the residue was dissolved in deionized water (60 mL). The aqueous phase was extracted twice with ether (40 mL × 2) to remove organic impurities. Subsequently, the pH of the aqueous phase was adjusted to 3 with 2 M aqueous hydrochloric acid, at which time a white solid precipitated. The white solid was collected by filtration and dried to give 6-(1H-pyrazol-1-yl)nicotinic acid (7.42 g, 97% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 6.65 (dd, J = 2.7, 1.6 Hz, 1H, Ar-H), 7.92 (dd, J = 1.6, 0.8 Hz, 1H, Ar-H), 8.04 (dd, J = 8.6, 0.8 Hz, 1H, Ar-H), 8.44 (dd, J = 8.6 , 2.3 Hz, 1H, Ar-H), 8.70 (dd, J = 2.7, 0.8 Hz, 1H, Ar-H), 8.96 (dd, J = 2.3, 0.8 Hz, 1H, Ar-H), 13.44 (s, 1H, COOH).

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 68 - 90
[2] Patent: WO2014/85210, 2014, A1. Location in patent: Page/Page column 40

6-(1H-Pyrazol-1-yl)nicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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253315-22-9, 6-(1H-Pyrazol-1-yl)nicotinic acidRelated Search:

Nicotinic acid Folic acid 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Pyridine Chromium picolinate Glycine Zolpidem tartrate 2-Picolinic acid Ethyl 2-(Chlorosulfonyl)acetate Pyraclostrobin Zolpidem Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate CARBOXYLIC ACID 6-(1H-Pyrazol-1-yl)nicotinic acid 5-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)nicotinic acid DIETHYL 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE 6-(4-nitro-1H-pyrazol-1-yl)pyridine-3-carboxylic acid 5-chloro-6-(1H-pyrazol-1-yl)nicotinic acid

  • 6-(1H-Pyrazol-1-yl)nicotinic acid ,97%
  • 6-(1H-Pyrazol-1-yl)pyridine-3-carboxylic acid
  • 6-(1H-Pyrazol-1-yl)nicotinic acid
  • 6-pyrazol-1-ylpyridine-3-carboxylic acid
  • 6-Pyrazol-1-yl-nicotinic acid
  • 3-Pyridinecarboxylic acid, 6-(1H-pyrazol-1-yl)-
  • 6-(1-Pyrazolyl)nicotinic Acid
  • CAS:253315-22-9
  • 6-(1H-Pyrazol-1-yl)-pyridin-3-carboxylic acid
  • 253315-22-9