6-(1H-Pyrazol-1-yl)nicotinic acid
- Product Name
- 6-(1H-Pyrazol-1-yl)nicotinic acid
- CAS No.
- 253315-22-9
- Chemical Name
- 6-(1H-Pyrazol-1-yl)nicotinic acid
- Synonyms
- CAS:253315-22-9;6-(1-Pyrazolyl)nicotinic Acid;6-Pyrazol-1-yl-nicotinic acid;6-(1H-Pyrazol-1-yl)nicotinic acid;6-(1H-Pyrazol-1-yl)nicotinic acid ,97%;6-pyrazol-1-ylpyridine-3-carboxylic acid;6-(1H-Pyrazol-1-yl)pyridine-3-carboxylic acid;6-(1H-Pyrazol-1-yl)-pyridin-3-carboxylic acid;3-Pyridinecarboxylic acid, 6-(1H-pyrazol-1-yl)-
- CBNumber
- CB01481996
- Molecular Formula
- C9H7N3O2
- Formula Weight
- 189.17
- MOL File
- 253315-22-9.mol
6-(1H-Pyrazol-1-yl)nicotinic acid Property
- Melting point:
- 272-274℃
- Boiling point:
- 394.6±27.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 3.28±0.10(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 253315-22-9
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- OR938164
- Product name
- 6-(1H-Pyrazol-1-yl)nicotinicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- Z3007
- Product name
- 6-(1H-Pyrazol-1-yl)nicotinicacid
- Packaging
- 1g
- Price
- $139
- Updated
- 2021/12/16
- Product number
- JK104641
- Product name
- 6-(1H-Pyrazol-1-yl)nicotinicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
- Product number
- OR938164
- Product name
- 6-(1H-Pyrazol-1-yl)nicotinicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $235
- Updated
- 2021/12/16
- Product number
- 033160
- Product name
- 6-(1H-Pyrazol-1-yl)nicotinic acid
- Packaging
- 500mg
- Price
- $246
- Updated
- 2021/12/16
6-(1H-Pyrazol-1-yl)nicotinic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
1428929-49-0
253315-22-9
Compound 1 (CAS: 1428929-49-0, 8.66 g, 40.43 mmol, 1.0 eq.) was dissolved in anhydrous ethanol (80 mL), followed by slow addition of 3 M aqueous sodium hydroxide solution (40.40 mL, 121.3 mmol, 3.0 eq.). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the solvent was removed by reduced pressure distillation and the residue was dissolved in deionized water (60 mL). The aqueous phase was extracted twice with ether (40 mL × 2) to remove organic impurities. Subsequently, the pH of the aqueous phase was adjusted to 3 with 2 M aqueous hydrochloric acid, at which time a white solid precipitated. The white solid was collected by filtration and dried to give 6-(1H-pyrazol-1-yl)nicotinic acid (7.42 g, 97% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 6.65 (dd, J = 2.7, 1.6 Hz, 1H, Ar-H), 7.92 (dd, J = 1.6, 0.8 Hz, 1H, Ar-H), 8.04 (dd, J = 8.6, 0.8 Hz, 1H, Ar-H), 8.44 (dd, J = 8.6 , 2.3 Hz, 1H, Ar-H), 8.70 (dd, J = 2.7, 0.8 Hz, 1H, Ar-H), 8.96 (dd, J = 2.3, 0.8 Hz, 1H, Ar-H), 13.44 (s, 1H, COOH).
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 68 - 90
[2] Patent: WO2014/85210, 2014, A1. Location in patent: Page/Page column 40
6-(1H-Pyrazol-1-yl)nicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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