Motesanib

Product Name: Motesanib
CAS No.: 453562-69-1
Chemical Name: Motesanib
Synonyms: D06678;CS-1108;motesanib;Motesanib Base;AMG 706; AMG-706;AMG-706(Motesanib);Motesanib (AMG-706) Base);2,4-Imidazolidinedione,5-(3-bromophenyl)-6-methyl-;N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide;N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide,AMG706
CBNumber: CB01518524
Molecular Formula: C22H23N5O
Formula Weight: 373.45
MOL File: 453562-69-1.mol

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Motesanib Property

Melting point:: 147-150°C
Boiling point:: 517.3±50.0 °C(Predicted)
Density: 1.251
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
form: White powder solid.
pka: 11.75±0.40(Predicted)
color: Pale Yellow

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M732500
Product name: Motesanib
Packaging: 50mg
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 017881
Product name: Motesanib
Packaging: 5mg
Price: $496
Updated: 2021/12/16

Adipogen Life Sciences

Product number: SYN-1055-M100
Product name: Motesanib
Purity: ≥95%
Packaging: 100mg
Price: $1069
Updated: 2021/12/16

AK Scientific

Product number: X4931
Product name: Motesanib
Packaging: 500mg
Price: $1265
Updated: 2021/12/16

Matrix Scientific

Product number: 132644
Product name: N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide
Purity: 97%
Packaging: 250mg
Price: $630
Updated: 2021/12/16

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Motesanib Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively.

Uses

Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.

Definition

ChEBI: Motesanib is a pyridinecarboxamide.

target

VEGFR1

Motesanib Preparation Products And Raw materials

Raw materials

Preparation Products

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Motesanib Suppliers

Canada 1 China 119 Germany 1 India 2 United Kingdom 3 United States 18 Global 144

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

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View Lastest Price from Motesanib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: motesanib 453562-69-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: Motesanib 453562-69-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kgs
Release date: 2020-01-02

453562-69-1, MotesanibRelated Search:

Xylene Imiquimod Dacthal Dimethyl fumarate N,N-Dimethylformamide Dimethyl carbonate Dimethyl sulfoxide Dimethyl sulfate Dimethyl phthalate Dimethyl ether ETHANE 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE Compound 23 ERK Inhibitor 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID Motesanib

CS-1108

AMG 706; AMG-706

N-(3,3-diMethylindolin-6-yl){2-[(4-pyridylMethyl)-aMino](3-pyridyl)}-carboxaMide

3-PyridinecarboxaMide, N-(2,3-dihydro-3,3-diMethyl-1H-indol-6-yl)-2-[(4-pyridinylMethyl)aMino]-

Motesanib Base

AMG-706(Motesanib)

Motesanib (AMG-706) Base)

motesanib

N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide

N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide

N-(3,3-dimethylindolin-6-yl)-2-(pyridin-4-ylmethylamino)nicotinamide,AMG706

D06678

2,4-Imidazolidinedione,5-(3-bromophenyl)-6-methyl-

453562-69-1

API

Inhibitors

Antineoplastic