5-IODOISATIN

Product Name: 5-IODOISATIN
CAS No.: 20780-76-1
Chemical Name: 5-IODOISATIN
Synonyms: NSC 92515;5-IODOISATIN;5-Iodoisatine;5-Iodoisatin>5-Iodoisatin 98%;5-IODOINDOLE-2,3-DIONE;5-IODO-2,3-INDOLINEDIONE;5-IODOINDOLINE-2,3-DIONE;5-Iodo-2,3-dioxoin-doline;5-Iodo-1H-indol-2,3-dione
CBNumber: CB0152710
Molecular Formula: C8H4INO2
Formula Weight: 273.03
MOL File: 20780-76-1.mol

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5-IODOISATIN Property

Melting point:: 276-280 °C(lit.)
Density: 2.106±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to crystal
pka: 8.87±0.20(Predicted)
color: Orange to Brown to Dark red
Water Solubility: Soluble acetone, acetic acid, ethanol. Insoluble in water.
Sensitive: Light Sensitive
BRN: 131248
CAS DataBase Reference: 20780-76-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HazardClass: LIGHT SENSITIVE
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 140589
Product name: 5-Iodoisatin
Purity: technical grade
Packaging: 5g
Price: $38.42
Updated: 2025/07/31

Sigma-Aldrich

Product number: 140589
Product name: 5-Iodoisatin
Purity: technical grade
Packaging: 25g
Price: $112
Updated: 2025/07/31

TCI Chemical

Product number: I0640
Product name: 5-Iodoisatin
Purity: >98.0%(T)
Packaging: 5g
Price: $72
Updated: 2025/07/31

TRC

Product number: I737145
Product name: 5-Iodoisatin
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR9765
Product name: 5-Iodoisatin
Purity: 97%
Packaging: 5g
Price: $18
Updated: 2021/12/16

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5-IODOISATIN Chemical Properties,Usage,Production

Uses

5-Iodoisatin undergoes condensation reaction with phenol yields 5-iodophenolisatin, malonic acid yields 6-iodo-2-quinolone-4-carboxylic acid.

Definition

ChEBI: 5-Iodoisatin is a member of indoles. It has a role as an anticoronaviral agent.

General Description

5-Iodoisatin undergoes condensation reaction with:

phenol yields 5-iodophenolisatin
malonic acid yields 6-iodo-2-quinolone-4-carboxylic acid

Synthesis

60313-92-0

20780-76-1

1. Preheat concentrated sulfuric acid (275 mL) at 60 °C. After stopping the heating, add p-iodoacetoacetanilide (22.0 g, 75.9 mmol) in batches with stirring, controlling the temperature to no more than 65 °C. 2. The reaction mixture was heated at 80 °C for 15 min. 3. After cooling to room temperature, it was further cooled to 0 °C and then the reaction mixture was slowly poured into crushed ice (550 g) and stirred at 0 °C for 1 hour. 4. The orange colored precipitate formed was collected by filtration and washed with water (110 mL). 5. Dissolve the precipitate in preheated 10% aqueous sodium hydroxide solution (55 mL, 60 °C). 6. Acetic acid (16.5mL) was added and heated at 60°C for 30 minutes. 7. After cooling to room temperature, further cooled to 0 °C, the precipitate was collected by filtration, washed with water (11 mL) and dried under vacuum to give 5-iodoindigo (17.1 g, 62.7 mmol) as an orange solid. 8. Yield 83%; melting point 272-274 °C (literature value: 272-274 °C); IR (KBr) ν 1198, 1458, 1606, 1731-1751, 3241 cm-1; 1H NMR (200 MHz, DMSO-d6) δ 6.75 (d, 1H, J=8.2 Hz, H-7), 7.76 (d, 1H. J=1.8Hz, H-4), 7.88 (dd, 1H, J=1.8,8.2Hz, H-6), 11.11 (s, 1H, NH); 13C NMR (50MHz, DMSO-d6) δ 85.8 (C-5), 115.2 (C-7), 120.4 (C-3a), 132.9 (C-4), 142.0 (C 6), 150.7 (C-7a), 159.3 (C-2), 183.7 (C-3).

References

[1] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
[2] Tetrahedron, 2005, vol. 61, # 25, p. 6082 - 6087
[3] Medicinal Chemistry, 2016, vol. 12, # 5, p. 489 - 498
[4] Chemische Berichte, 1924, vol. 57, p. 1773
[5] European Journal of Pharmacology, 2007, vol. 556, # 1-3, p. 200 - 206

5-IODOISATIN Preparation Products And Raw materials

Raw materials

Isatin Iodine monochloride

Preparation Products

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5-IODOISATIN Suppliers

Americas 1 China 126 Europe 3 Germany 2 India 7 Japan 1 Switzerland 3 Ukraine 1 United Kingdom 14 United States 16 Global 174

J & K SCIENTIFIC LTD.

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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View Lastest Price from 5-IODOISATIN manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-IODOISATIN 20780-76-1
Price: US $25.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2024-11-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-IODOISATIN 20780-76-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-Iodoisatin 20780-76-1
Price: US $15.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-02

20780-76-1, 5-IODOISATINRelated Search:

Potassium dichromate Phosphorus pentoxide 3-Iodotoluene Oxindole 4-Iodoaniline 5-IODOISATIN Formamide, N-(2-formylphenyl)- (9CI) 2-Aminoecetophenone 5-IODOINDOLE Isatin 4-IODO-2-METHYLANILINE N-(4-Iodophenyl)acetamide 3'-IODOACETOPHENONE 2-ETHYL-4-IODO-PHENYLAMINE 6-IODO-2,3-DIHYDRO-1H-INDOLE 2H-INDOL-2-ONE, 1,3-DIHYDRO-5-IODO- 4-IODO-N-METHYLANILINE tribulin

5-IODOINDOLINE-2,3-DIONE

5-IODOISATIN

5-IODO-2,3-INDOLINEDIONE

1H-Indole-2,3-dione,5-iodo-

5-Iodo-1H-indole-2,3-dione

5-Iodo-2,3-dioxoin-doline

5-Iodoisatin 98%

5-Iodoisatine

5-IODOINDOLE-2,3-DIONE

5-iodo-2,3-dihydro-1H-indole-2,3-dione

5-Iodoindolin-2,3-dione, 5-Iodo-1H-indole-2,3-dione

5-Iodoindole-2,3-dione 5-Iodo-2,3-indolinedione

5-Iodoisatin technical grade

NSC 92515

5-Iodoisatin&gt

5-IODOISATIN ISO 9001：2015 REACH

5-amino-6-fluoropyridine-8-carbonitrile

5-Iodo-1H-indol-2,3-dione

20780-76-1

C8H4INO2

Heterocyclic Building Blocks

Halogenated Heterocycles

Simple Indoles

Indoles

Building Blocks

Simple Indoles

Halogenated Heterocycles

Heterocyclic Building Blocks

IndolesBuilding Blocks

Indane/Indanone and Derivatives

Indoles