4-IODO-2-METHYLANILINE
- Product Name
- 4-IODO-2-METHYLANILINE
- CAS No.
- 13194-68-8
- Chemical Name
- 4-IODO-2-METHYLANILINE
- Synonyms
- AURORA 1126;4-Iodo-2-methyL;BUTTPARK 24\04-61;AKOS BBS-00007953;4-iodo-2-methylanil;4-Iodo-o-toluidine;2-AMINO-5-IODOTOLUENE;4-IODO-2-METHYLANILINE;4-Iodo-2-Methylalinine;Aniline, 4-iodo-2-methyl-
- CBNumber
- CB9712432
- Molecular Formula
- C7H8IN
- Formula Weight
- 233.05
- MOL File
- 13194-68-8.mol
4-IODO-2-METHYLANILINE Property
- Melting point:
- 86-89 °C (lit.)
- Boiling point:
- 278.4±28.0 °C(Predicted)
- Density
- 1.791±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 3.66±0.10(Predicted)
- color
- Purple to Dark purple to Dark red
- Sensitive
- Light Sensitive
- BRN
- 2353618
- InChI
- InChI=1S/C7H8IN/c1-5-4-6(8)2-3-7(5)9/h2-4H,9H2,1H3
- InChIKey
- BGKLFAQCHHCZRZ-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(I)C=C1C
- CAS DataBase Reference
- 13194-68-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-26,36/37/39
- RIDADR
- 2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214300
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 454788
- Product name
- 4-Iodo-2-methylaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $32.3
- Updated
- 2023/01/07
- Product number
- 454788
- Product name
- 4-Iodo-2-methylaniline
- Purity
- 97%
- Packaging
- 10g
- Price
- $197
- Updated
- 2023/01/07
- Product number
- I0690
- Product name
- 4-Iodo-2-methylaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- I0690
- Product name
- 4-Iodo-2-methylaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- I737258
- Product name
- 4-Iodo-2-methylaniline
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
4-IODO-2-METHYLANILINE Chemical Properties,Usage,Production
Chemical Properties
Grey to purple crystals
Synthesis
583-75-5
13194-68-8
General procedure for the synthesis of 4-iodo-2-methylaniline from 2-methyl-4-bromoaniline: the aromatic Finkelstein reaction is used. Since copper(I) iodide is sensitive to moisture and oxygen, the reaction is carried out under argon protection using the standard Schlenk technique. The procedure is as follows: 2-methyl-4-bromoaniline, NaI (2 equiv., relative to bromine exchange) and CuI (5 mol%, relative to bromine exchange) are added to a two-necked pear-shaped flask equipped with a reflux condenser. N,N'-dimethylethylenediamine (L1) or N,N'-dimethyl-1,2-cyclohexanediamine (L2) (10 mol%, relative to bromine exchange) and anhydrous 1,4-dioxane (0.5 mL per 1 mmol NaI) were subsequently added. The resulting suspension was heated to 110°C and reacted for 18 hours. After completion of the reaction, it was cooled to room temperature and the mixture was poured into a 25% ammonia solution. The blue solution was diluted with deionized water until doubled in volume and extracted three times with dichloromethane. If 2,2'-bipyridine was used as the ligand, the combined organic phases were additionally washed with aqueous EDTA; otherwise, the combined organic phases were washed with saturated saline only and dried with anhydrous magnesium sulfate. The solvent is removed by concentration under reduced pressure to give pure 4-iodo-2-methylaniline. If necessary, the crude product can be further purified by column chromatography or recrystallization.
Purification Methods
Crystallise it from 50% EtOH. [Beilstein 12 IV 1807.]
References
[1] Synthesis (Germany), 2014, vol. 46, # 8, p. 1085 - 1090
[2] Journal of the American Chemical Society, 2015, vol. 137, # 26, p. 8328 - 8331
4-IODO-2-METHYLANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-IODO-2-METHYLANILINE manufacturers
- Product
- 4-IODO-2-METHYLANILINE 13194-68-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-29
- Product
- 4-IODO-2-METHYLANILINE 13194-68-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-11
- Product
- 4-IODO-2-METHYLANILINE 13194-68-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08