5-IODOISATIN
- Product Name
- 5-IODOISATIN
- CAS No.
- 20780-76-1
- Chemical Name
- 5-IODOISATIN
- Synonyms
- NSC 92515;5-IODOISATIN;5-Iodoisatine;5-Iodoisatin>5-Iodoisatin 98%;5-IODOINDOLE-2,3-DIONE;5-IODO-2,3-INDOLINEDIONE;5-IODOINDOLINE-2,3-DIONE;5-Iodo-2,3-dioxoin-doline;5-Iodo-1H-indol-2,3-dione
- CBNumber
- CB0152710
- Molecular Formula
- C8H4INO2
- Formula Weight
- 273.03
- MOL File
- 20780-76-1.mol
5-IODOISATIN Property
- Melting point:
- 276-280 °C(lit.)
- Density
- 2.106±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 8.87±0.20(Predicted)
- color
- Orange to Brown to Dark red
- Water Solubility
- Soluble acetone, acetic acid, ethanol. Insoluble in water.
- Sensitive
- Light Sensitive
- BRN
- 131248
- CAS DataBase Reference
- 20780-76-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38-43
- Safety Statements
- 26-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- LIGHT SENSITIVE
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 140589
- Product name
- 5-Iodoisatin
- Purity
- technical grade
- Packaging
- 5g
- Price
- $38.42
- Updated
- 2025/07/31
- Product number
- 140589
- Product name
- 5-Iodoisatin
- Purity
- technical grade
- Packaging
- 25g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- I0640
- Product name
- 5-Iodoisatin
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $72
- Updated
- 2025/07/31
- Product number
- I737145
- Product name
- 5-Iodoisatin
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR9765
- Product name
- 5-Iodoisatin
- Purity
- 97%
- Packaging
- 5g
- Price
- $18
- Updated
- 2021/12/16
5-IODOISATIN Chemical Properties,Usage,Production
Uses
5-Iodoisatin undergoes condensation reaction with phenol yields 5-iodophenolisatin, malonic acid yields 6-iodo-2-quinolone-4-carboxylic acid.
Definition
ChEBI: 5-Iodoisatin is a member of indoles. It has a role as an anticoronaviral agent.
General Description
5-Iodoisatin undergoes condensation reaction with:
- phenol yields 5-iodophenolisatin
- malonic acid yields 6-iodo-2-quinolone-4-carboxylic acid
Synthesis
60313-92-0
20780-76-1
1. Preheat concentrated sulfuric acid (275 mL) at 60 °C. After stopping the heating, add p-iodoacetoacetanilide (22.0 g, 75.9 mmol) in batches with stirring, controlling the temperature to no more than 65 °C. 2. The reaction mixture was heated at 80 °C for 15 min. 3. After cooling to room temperature, it was further cooled to 0 °C and then the reaction mixture was slowly poured into crushed ice (550 g) and stirred at 0 °C for 1 hour. 4. The orange colored precipitate formed was collected by filtration and washed with water (110 mL). 5. Dissolve the precipitate in preheated 10% aqueous sodium hydroxide solution (55 mL, 60 °C). 6. Acetic acid (16.5mL) was added and heated at 60°C for 30 minutes. 7. After cooling to room temperature, further cooled to 0 °C, the precipitate was collected by filtration, washed with water (11 mL) and dried under vacuum to give 5-iodoindigo (17.1 g, 62.7 mmol) as an orange solid. 8. Yield 83%; melting point 272-274 °C (literature value: 272-274 °C); IR (KBr) ν 1198, 1458, 1606, 1731-1751, 3241 cm-1; 1H NMR (200 MHz, DMSO-d6) δ 6.75 (d, 1H, J=8.2 Hz, H-7), 7.76 (d, 1H. J=1.8Hz, H-4), 7.88 (dd, 1H, J=1.8,8.2Hz, H-6), 11.11 (s, 1H, NH); 13C NMR (50MHz, DMSO-d6) δ 85.8 (C-5), 115.2 (C-7), 120.4 (C-3a), 132.9 (C-4), 142.0 (C 6), 150.7 (C-7a), 159.3 (C-2), 183.7 (C-3).
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
[2] Tetrahedron, 2005, vol. 61, # 25, p. 6082 - 6087
[3] Medicinal Chemistry, 2016, vol. 12, # 5, p. 489 - 498
[4] Chemische Berichte, 1924, vol. 57, p. 1773
[5] European Journal of Pharmacology, 2007, vol. 556, # 1-3, p. 200 - 206
5-IODOISATIN Preparation Products And Raw materials
Raw materials
Preparation Products
5-IODOISATIN Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 5-IODOISATIN manufacturers
- Product
- 5-IODOISATIN 20780-76-1
- Price
- US $25.00/ASSAYS
- Min. Order
- 100ASSAYS
- Purity
- 99.5%
- Supply Ability
- 100 mt
- Release date
- 2024-11-18
- Product
- 5-IODOISATIN 20780-76-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-10
- Product
- 5-Iodoisatin 20780-76-1
- Price
- US $15.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-02