Ispinesib

ChemicalBook > CAS DataBase List > Ispinesib

Product Name: Ispinesib
CAS No.: 336113-53-2
Chemical Name: Ispinesib
Synonyms: 3-(6;CS-376;SB-71599;Ispinesib;SB 715992;CK0238273;Ispinesib2;Unii-bkt5F9C2ni;Ispinesib, >=98%;SB715992 (Ispinesib)
CBNumber: CB01565568
Molecular Formula: C30H33ClN4O2
Formula Weight: 517.06
MOL File: 336113-53-2.mol

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Ispinesib Property

Melting point:: 89 - 92°C
Boiling point:: 708.0±70.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 9.65±0.10(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18014
Product name: Ispinesib
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18014
Product name: Ispinesib
Purity: ≥98%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 18014
Product name: Ispinesib
Purity: ≥98%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 18014
Product name: Ispinesib
Purity: ≥98%
Packaging: 50mg
Price: $1062
Updated: 2024/03/01

Tocris

Product number: 5408
Product name: Ispinesib
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1153
Updated: 2021/12/16

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Ispinesib Chemical Properties,Usage,Production

Uses

The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells. Ispinesib is a cell-permeable, allosteric inhibitor of Eg5 (Ki app = 2.3 nM) with >10,000-fold selectivity for Eg5 over a range of other mitotic kinesins. It induces a monopolar spindle phenotype, leading to the activation of a spindle assembly checkpoint, mitotic arrest, and subsequent cell death (GI50s = 22-82 nM in colon, pancreas, prostrate, and lung cancer cells in vitro). At 10 mg/kg, ispinesib produces tumor regression of breast cancer cell xenografts in mice. It has also been used to halt the growth of treatment-resistant glioblastoma tumor-initiating cells, to prevent tumor initiation and self-renewal of a cancer stem cell population (EC50 = 1.15 nM), and to reduce glioma cell invasion.[Cayman Chemical]

Definition

ChEBI: N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide is a member of benzamides.

Biological Activity

ispinesib (sb-715992) is a selective inhibitor of ksp with ic50 value of 0.5 nm [1].kinesin spindle protein (ksp) is a kinesin motor protein and plays an important role in the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. it has been shown that abnormal expression of ksp is correlated with a variety of human cancers and its inhibitors may be a promising anticancer agent [2] [3].ispinesib (sb-715992) is a potent ksp inhibitor and often combines with chemotherapy drugs to tumor treatment. when tested with a panel of 23 tumor cell lines, ispinesib (sb-715992) treatment showed high activity to inhibit ksp in most of the cell lines while only rh18 having an ic50 value greater than 1 μm (median ic50=4.1 nm, maximum ic50=0.5 nm) by using pptp method [1]. in a panel of 53 breast cell lines, ispinesib (sb-715992) exhibits broad antiproliferative activity and up-regulated the expression of both mitotic and apoptotic markers in mda-mb-468 cell line [2]. when tested with pc-3 cells, ispinesib (sb-715992) treatment inhibits cell proliferation, inducs cell apoptosis and up-regulated the expressions of genes that related to the control of cell proliferation, cell cycle, cell signaling pathways and apoptosis [3].in mouse model with 26 tumor cells subcutaneous xenograft, administration of ispinesib (sb-715992) inducs markedly tumor growth delay with the percent of 88% (23/26) and maintained completed response (cr) in the rhaboid tumor, wilms tumor and ewing sarcoma xenograft mouse model [1].

storage

Store at -20°C

References

[1]. carol, h., et al., initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. pediatr blood cancer, 2009. 53(7): p. 1255-63.
[2]. purcell, j.w., et al., activity of the kinesin spindle protein inhibitor ispinesib (sb-715992) in models of breast cancer. clin cancer res, 2010. 16(2): p. 566-76.
[3]. davis, d.a., et al., increased therapeutic potential of an experimental anti-mitotic inhibitor sb715992 by genistein in pc-3 human prostate cancer cell line. bmc cancer, 2006. 6: p. 22.

Ispinesib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ispinesib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ispinesib 336113-53-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ispinesib 336113-53-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

336113-53-2, IspinesibRelated Search:

SB 225002 SB 242084 (hydrochloride) SB 415286 SB 202190 SB 431542 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 269970 HYDROCHLORIDE SB1317 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 SB242235 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride LY2603618 Bortezomib MK-1775 SB 743921

Ispinesib

N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide

SB 715992

Benzamide, N-(3-aminopropyl)-N-((1R)-1-(7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl)-2-methylpropyl)-4-methyl-

Unii-bkt5F9C2ni

Ispinesib2

SB-71599

Ispinesib (SB-715992 /CK0238273)

Ispinesib Mesilate(SB-715992)

Ispinesib (SB-715992)

BenzaMide, N-(3-aMinopropyl)-N-((1R)-1-(7-chloro-3,4-dihydro-4-oxo-3-(phenylMethyl)-2-quinazolinyl)-2-Methylprop

(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide

CK0238273

Ispinesib N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide

N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide Ispinesib(SB-715992)

SB715992 (Ispinesib)

Ispinesib, >=98%

(R)-N-(3-Aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl

ISPINESIB;SB-715992;SB715992

CS-376

3-(6

(R)-N-(3-Aminopropyl)-N-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-2-quinazolinyl)-2-methylpropyl]-4-methylbenzamide

336113-53-2

C30H33ClN4O2

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