Biological Activities
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Theaflavin 3,3'-digallate

Biological Activities
Product Name
Theaflavin 3,3'-digallate
CAS No.
30462-35-2
Chemical Name
Theaflavin 3,3'-digallate
Synonyms
TFDG;8-Gingerol;theaflavin 3;8-Gingerol Hplc;8-GINGEROL, HPLC 98%;Theaflavin 3,3’[8]-Gingerol fandachem;THEAFLAVIN 3,3'-DIGALLATE;THEAFLAVIN 3,3'-DI-O-GALLATE;Theaflavin-3,3-digallate(TF3)
CBNumber
CB0156596
Molecular Formula
C43H32O20
Formula Weight
868.71
MOL File
30462-35-2.mol
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Theaflavin 3,3'-digallate Property

Melting point:
226~230℃
Boiling point:
1352.6±65.0 °C(Predicted)
Density 
1.97±0.1 g/cm3(Predicted)
form 
neat
pka
6.55±0.20(Predicted)
InChIKey
ZEASWHWETFMWCV-ISBUVJFSSA-N
CAS DataBase Reference
30462-35-2
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Safety

WGK Germany 
3
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G5923
Product name
[8]-Gingerol
Packaging
5 mg
Price
$215
Updated
2021/12/16
Sigma-Aldrich
Product number
PHL83344
Product name
Theaflavin 3,3′-digallate
Purity
phyproof? Reference Substance
Packaging
10mg
Price
$313
Updated
2021/12/16
Sigma-Aldrich
Product number
G5923
Product name
[8]-Gingerol
Packaging
10 mg
Price
$398
Updated
2021/12/16
Sigma-Aldrich
Product number
01514
Product name
[8]-Gingerol
Purity
analytical standard
Packaging
10 mg
Price
$516
Updated
2021/12/16
Sigma-Aldrich
Product number
92223
Product name
Theaflavin 3,3′-digallate
Purity
analytical standard
Packaging
1mg
Price
$646
Updated
2021/12/16
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Theaflavin 3,3'-digallate Chemical Properties,Usage,Production

Biological Activities

Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities. It has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 µmol/L, respectively).
It also reduces hydroxyl radical-induced damage to plasmid DNA. TFDG (12.5-50 µM) prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells [2]. In vivo, TFDG reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner. 

Description

Theaflavin-3,3''-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities. It has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively). It also reduces hydroxyl radical-induced damage to plasmid DNA. TFDG (12.5-50 μM) prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells. In vivo, TFDG reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner.

Uses

Theaflavin 3,3''-Digallate has been found to be an inhibitor against human pancreatic α-Amylase.

Theaflavin 3,3'-digallate Preparation Products And Raw materials

Raw materials

Preparation Products

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Theaflavin 3,3'-digallate Suppliers

J & K SCIENTIFIC LTD.
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010-82848833- ;010-82848833-
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86-10-82849933
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jkinfo@jkchemical.com;market6@jkchemical.com
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China
ProdList
96815
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76
BEST-REAGENT
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400-1166-196;028-84555506- ;028-84555506-
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cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
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China
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China Langchem Inc.
Tel
0086-21-58956006;021-38701807;021-58950017
Fax
0086-21-58956100
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China
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BOC Sciences
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info@bocsci.com
Country
United States
ProdList
21113
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ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847-
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021-55068248
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3008007399@qq.com
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China
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Chengdu Biopurify Phytochemicals Ltd.
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028-82633397-
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+86-28-82633165
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daisy@biopurify.cn
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China
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Shanghai Winherb Medical Technology Co., Ltd.
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136-81877033- ;
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QQ:190129269
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winherb@126.com;2702713455@qq.com
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China
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Cheng Du Micxy Chemical Co.,Ltd
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028-85632863-
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028-85632863
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sales@micxy.com;
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China
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13065
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Shanghai Tauto Biotech Co., Ltd.
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021-51320588
Fax
0086-21-51320502
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tauto@tautobiotech.com
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China
ProdList
4041
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66
Shanghai TaoShu Biochemical Technology Co., Ltd.
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021-33632979-
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021-33632979
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service1@targetmol.com
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China
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View Lastest Price from Theaflavin 3,3'-digallate manufacturers

Career Henan Chemical Co
Product
8-Gingerol 30462-35-2
Price
US $100.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
customise
Release date
2018-07-26

30462-35-2, Theaflavin 3,3'-digallateRelated Search:


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  • THEAFLAVIN 3,3'-DI-O-GALLATE
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