4-CYANOTHIAZOLE

Product Name: 4-CYANOTHIAZOLE
CAS No.: 1452-15-9
Chemical Name: 4-CYANOTHIAZOLE
Synonyms: 4-CYANOTHIAZOLE;4-thiazolecarbonitrile;thiazole-4-carbonitrile;1,3-thiazole-4-carbonitrile
CBNumber: CB0164818
Molecular Formula: C4H2N2S
Formula Weight: 110.14
MOL File: 1452-15-9.mol

More

Less

4-CYANOTHIAZOLE Property

Melting point:: 60-61℃
Boiling point:: 100-120℃ (20 Torr)
Density: 1.393 (estimate)
refractive index: 1.5500 (estimate)
storage temp.: Sealed in dry,Room Temperature
pka: -1.45±0.10(Predicted)
Appearance: Light yellow to yellow Solid
EPA Substance Registry System: 4-Thiazolecarbonitrile (1452-15-9)

More

Less

Safety

Risk Statements: 10-20/21/22-36
Safety Statements: 16-26-36
RIDADR: 3275
HS Code: 2934100090
Hazardous Substances Data: 1452-15-9(Hazardous Substances Data)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: C982308
Product name: 4-Cyanothiazole
Packaging: 50mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C982308
Product name: 4-Cyanothiazole
Packaging: 100mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC154283
Product name: 4-Cyanothiazole
Packaging: 500mg
Price: $120
Updated: 2021/12/16

Ark Pharm

Product number: P000176588
Product name: 4-Cyanothiazole
Purity: 97%
Packaging: 100mg
Price: $39
Updated: 2021/12/16

Ark Pharm

Product number: P000176588
Product name: 4-Cyanothiazole
Purity: 97%
Packaging: 1g
Price: $131
Updated: 2021/12/16

More

Less

4-CYANOTHIAZOLE Chemical Properties,Usage,Production

Uses

4-Cyanothiazole is a useful pharamaceutical intermediate.

Synthesis

3575-09-5

1452-15-9

General procedure for the synthesis of 4-cyanothiazole from thiazole-4-carboxamide: 500 g of thiazole-4-carboxamide (chemically pure) was added to a 1 L open reactor and the stirrer was started (600 r/min). Ammonia (chemically pure, 5.1 wt% water) was continuously vented from the bottom of the reactor at a controlled flow rate of 100 g/min. after TC hours of reaction at reaction temperature TA, the vented ammonia was stopped. Samples of the reaction mixture were taken for NMR hydrogen spectroscopy and elemental analysis to characterize the amide intermediates generated. The specific reaction conditions and characterization results are shown in Tables A-1 to A-6. The characterization results showed that the purity of the resulting amide intermediate was higher than 99%. In this embodiment, ammonia can be replaced by waste ammonia (source: Yangzi Petrochemical Plant, containing about 50 wt% ammonia, with toluene, oxygen, nitrogen, steam, carbon monoxide and carbon dioxide as the remaining components), at which time the flow rate of the waste ammonia should be adjusted to 130 g/min.

References

[1] Patent: CN104557357, 2018, B. Location in patent: Paragraph 0150; 0151; 0152; 0162
[2] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 6, p. 628 - 633
[3] Helvetica Chimica Acta, 1957, vol. 40, p. 554,558
[4] Bulletin de la Societe Chimique de France, 1969, p. 4026 - 4031
[5] Journal of the Chemical Society, 1960, p. 916 - 925

4-CYANOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-CYANOTHIAZOLE Suppliers

China 50 Germany 3 India 1 United Kingdom 2 United States 10 Global 66

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Aagile Labs Division of Tyger Scientific

Tel: --
Fax: --
Email: tygersci@yahoo.com
Country: United States
ProdList: 6568
Advantage: 68

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Davos Chemical Corporation

Tel: --
Fax: --
Email: info@davos.com
Country: United States
ProdList: 1640
Advantage: 65

1452-15-9, 4-CYANOTHIAZOLERelated Search:

4-HYDROXYPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE 2-Pyridinecarbonitrile,4-hydroxy-(9CI) 1H-indazole-4-carbonitrile Acetamidine hydrochloride 4-Thiazolecarboxylic acid ETHYL THIAZOLE-4-CARBOXYLATE 4-CYANOTHIAZOLE 2-BROMO-4-CYANOTHIAZOLE 2-Aminothiazole-4-carbonitrile 5-AMINO-2-(4-NITROANILINO)-1,3-THIAZOLE-4-CARBONITRILE 2-METHYL-1,3-THIAZOLE-4-CARBONITRILE 2-AMINO-5-BROMOTHIAZOLE-4-CARBONITRILE Carbamic acid, N-(5-bromo-4-cyano-2-thiazolyl)-, 1,1-dimethylethyl ester 5-amino-2-[3-(trifluoromethyl)anilino]-1,3-thiazole-4-carbonitrile 2-(1H-IMIDAZOL-2-YL)-THIAZOLE-4-CARBONITRILE 2-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL]-1,3-THIAZOLE-4-CARBONITRILE 5-amino-2-anilino-1,3-thiazole-4-carbonitrile 2-amino-1,3-thiazole-4-carbonitrile 3-oxide

4-thiazolecarbonitrile

4-CYANOTHIAZOLE

thiazole-4-carbonitrile

1,3-thiazole-4-carbonitrile

1452-15-9

C4H2N2S