tert-Butyl N-(4-aminobutyl)carbamate

Product Name: tert-Butyl N-(4-aminobutyl)carbamate
CAS No.: 68076-36-8
Chemical Name: tert-Butyl N-(4-aminobutyl)carbamate
Synonyms: N-BOC-1,4-BUTANEDIAMINE;N-BOC-1,4-DIAMINOBUTANE;N-(TERT-BUTOXYCARBONYL)-1,4-DIAMINOBUTANE;BOC-DAB HCL;AURORA KA-4397;Boc-NH-(CH2)4-NH2;BUTTPARK 121\06-09;RARECHEM AR PA 0023;BOC-NH(CH2)4NH2 HCL;BOC-DIAMINOBUTANE HCL
CBNumber: CB0166423
Molecular Formula: C9H20N2O2
Formula Weight: 188.27
MOL File: 68076-36-8.mol

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tert-Butyl N-(4-aminobutyl)carbamate Property

Boiling point:: 292.9±23.0 °C(Predicted)
Density: 0.984 g/mL at 20 °C(lit.)
refractive index: n20/D 1.460
Flash point:: 109 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, DMSO, Methanol
pka: 12.86±0.46(Predicted)
form: Liquid
color: Clear colorless to light yellow
BRN: 1937878
InChI: InChI=1S/C9H20N2O2/c1-9(2,3)13-8(12)11-7-5-4-6-10/h4-7,10H2,1-3H3,(H,11,12)
InChIKey: ZFQWJXFJJZUVPI-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCCCN
CAS DataBase Reference: 68076-36-8(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34-24
Safety Statements: 26-36/37/39-45
RIDADR: UN 2735 8/PG 3
WGK Germany: 3
F: 10-34
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15404
Product name: N-Boc-1,4-butanediamine
Purity: ≥97.0% (GC/NT)
Packaging: 1ml
Price: $82.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15404
Product name: N-Boc-1,4-butanediamine
Purity: ≥97.0% (GC/NT)
Packaging: 5ml
Price: $392
Updated: 2025/07/31

TCI Chemical

Product number: A1373
Product name: N-(tert-Butoxycarbonyl)-1,4-diaminobutane
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $64
Updated: 2025/07/31

TCI Chemical

Product number: A1373
Product name: N-(tert-Butoxycarbonyl)-1,4-diaminobutane
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $182
Updated: 2025/07/31

TCI Chemical

Product number: A1373
Product name: N-(tert-Butoxycarbonyl)-1,4-diaminobutane
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $607
Updated: 2025/07/31

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tert-Butyl N-(4-aminobutyl)carbamate Chemical Properties,Usage,Production

Chemical Properties

Clear colourless viscous liquid

Uses

N-Boc-1,4-diaminobutane is used in preparation of pharmacologically active compounds, preparation of spermidine analogues and in introduction of a C4-spacer. It serve as intermediates of medicine.

Uses

suzuki reaction

reaction suitability

reagent type: cross-linking reagent

Synthesis

24424-99-5

110-60-1

68076-36-8

Synthesis of compound 19: 1,4-Butanediamine (1 g, 11.36 mmol, 5 eq.) was dissolved in dichloromethane (15 ml). To this solution was slowly added di-tert-butyl dicarbonate (Boc2O, 0.619 g, 2.83 mmol, 1 eq.) dissolved in dichloromethane (15 ml). The reaction mixture was stirred at room temperature for 16 hours. The reaction progression was monitored by thin layer chromatography (TLC, unfolding agent ratio CH2Cl2:MeOH:33% NH4OH aqueous solution = 8:2:0.2). Upon completion of the reaction, the reaction mixture was filtered to remove insoluble impurities and the filtrate was concentrated by rotary evaporator. The resulting oily residue was dissolved with ethyl acetate (15 ml) and washed with saturated sodium chloride solution (3 x 10 ml) to remove unreacted 1,4-butanediamine. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 0.520 g of yellow oily product in 97.65% yield. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 1.38 (s, 9H), 1.52-1.59 (m, 4H), 2.34 (brs, 2H, D2O exchange), 2.72-2.79 (m, 2H), 3.19-3.24 (m, 2H), 5.95 (brs, 1H, D2O exchange).

IC 50

Alkyl/ether

References

[1] Journal of Organic Chemistry, 1997, vol. 62, # 2, p. 411 - 416
[2] Organic Letters, 2001, vol. 3, # 8, p. 1205 - 1208
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 20, p. 7145 - 7155
[4] Journal of Materials Chemistry, 2011, vol. 21, # 13, p. 4850 - 4860
[5] Organic Letters, 2015, vol. 17, # 22, p. 5626 - 5629

tert-Butyl N-(4-aminobutyl)carbamate Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Chloroform Hydrochloric acid Acetic acid Methanol Sodium hydroxide 1,4-DIAMINOBUTANE

Preparation Products

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View Lastest Price from tert-Butyl N-(4-aminobutyl)carbamate manufacturers

Hebei Fengjia New Material Co., Ltd

Product: tert-Butyl N-(4-aminobutyl)carbamate 68076-36-8
Price: US $56.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2024-08-16

Hebei Chuanghai Biotechnology Co., Ltd

Product: tert-Butyl N-(4-aminobutyl)carbamate 68076-36-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2025-03-14

Hebei Chuanghai Biotechnology Co,.LTD

Product: tert-Butyl N-(4-aminobutyl)carbamate 68076-36-8
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

68076-36-8, tert-Butyl N-(4-aminobutyl)carbamateRelated Search:

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RARECHEM AR PA 0023

TERT-BUTYL N-(4-AMINOBUTYL)CARBAMATE

N-TERT-BUTYLOXYCARBONYL-1,4-DIAMINOBUTANE HYDROCHLORIDE

N-T-BUTYLOXYCARBONYL-1,4-DIAMINOBUTANE HYDROCHLORIDE

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N-1-BOC-1,4-DIAMINOBUTANE HCL

N-1-T-BUTOXYCARBONYL-1,4-DIAMINOBUTANE HYDROCHLORIDE

MONO-4-N-BOC-1,4-DIAMINOBUTANE

1-BOC-AMINO-1,4-BUTANEDIAMINE

(4-AMINOBUTYL)CARBAMIC ACID E-TERT-BUTYL ESTER HYDROCHLORIDE

BUTTPARK 121\06-09

BOC-DIAMINOBUTANE HCL

BOC-DAB HCL

BOC-NH(CH2)4NH2 HCL

BOC-1,4-DIAMINOBUTANE HCL

BOC-1,4-DIAMINOBUTANE HYDROCHLORIDE

AURORA KA-4397

4-Aminobutylcarbamic Acid tert-Butyl Ester

N-Boc-1,4-butanediamine≥ 98%(GC)

N-t-BOC-1,4-DIAMINOBUTANE

(4-Amino-butyl)-carbamic acid tert-butyl ester N-t-BOC-1,4-DIAMINOBUTANE tert-Butyl N-(4-Aminobutyl)carbamate N-(4-Aminobutyl)carbamic acid tert-butyl ester

N-Boc-1,4-diaminobutane, tert-Butyl N-(4-aminobutyl)carbamate

N-Boc-1,4-butandiamine

N-Boc-1,4-Diaminobutane ,98%

N-(4-Aminobutyl)carbamic Acid tert-Butyl Ester N-Boc-1,4-butanediamine N-Boc-1,4-diaminobutane N-(tert-Butoxycarbonyl)-1,4-butanediamine tert-Butyl N-(4-Aminobutyl)carbamate

N-Boc-1,4-Diaminobutane ,90%

tert-Butyl N-(4-aMinobutyl)car

tert-Butyl N-(4-aMiNAbutyl)carbaMate

N-Boc-1,4-butanediaMine >=97.0% (GC/NT)

N-Boc-1,4-butanediaMine, 95+%

Boc-1,4-diaminobutane

N-(tert-Butoxycarbonyl)-1,4-diaminobutane &gt

N-Boc-1,4-diaminobutane, 98%, for synthesis

Carbamic acid, N-(4-aminobutyl)-, 1,1-dimethylethyl ester

ert-ButylN-(4-aminobutyl)carbamate

tert-Butyl N-(4-aminobutyl)carbamate ISO 9001：2015 REACH

Inhibitor,PROTAC,PROTAC Linkers,NH-2-C4-NH-Boc,NH2C4NHBoc,Alkyl/ether,NH2 C4 NH Boc,inhibit,linker

Boc-NH-(CH2)4-NH2

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

NH2-C4-NH-Boc, 10 mM in DMSO

<i>N</i>-Boc-1,4-butanediamine

68076-36-8

CH33COCONHCH24NH2

68076368

Monoprotected Diaminoalkanes

N-Boc-diaminoalkanes

Protected Amines

Organic Building Blocks

Nitrogen Compounds

Building Blocks

Bifunctional Linkers

Building Blocks