D-Homoserine

Product Name: D-Homoserine
CAS No.: 6027-21-0
Chemical Name: D-Homoserine
Synonyms: H-D-HSE-OH;D-Homoserin;D-HOMOSERINE;H-D-HOSER-OH;(R) HOMOSERINE;H-D-Homoser-OH;D-Beta-Homo-Ser;D-Homoserine>D-Homoserine,97%;dextro-homoserine
CBNumber: CB0168533
Molecular Formula: C4H9NO3
Formula Weight: 119.12
MOL File: 6027-21-0.mol

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D-Homoserine Property

Melting point:: 205 °C (dec.) (lit.)
alpha: 9 º ((c=5, H2O))
Boiling point:: 368.7±32.0 °C(Predicted)
Density: 1.312±0.06 g/cm3(Predicted)
refractive index: 8.0 ° (C=2, H2O)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 2.21±0.10(Predicted)
form: powder to crystal
color: White to Orange to Green
Water Solubility: Soluble
BRN: 1721680
InChI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m1/s1
InChIKey: UKAUYVFTDYCKQA-GSVOUGTGSA-N
SMILES: C(O)(=O)[C@@H](CCO)N
LogP: -1.289 (est)
CAS DataBase Reference: 6027-21-0(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H4021
Product name: D-Homoserine
Packaging: 250mg
Price: $96
Updated: 2025/07/31

Sigma-Aldrich

Product number: H4021
Product name: D-Homoserine
Packaging: 1g
Price: $667
Updated: 2025/07/31

TCI Chemical

Product number: H1224
Product name: D-Homoserine
Purity: >96.0%(T)
Packaging: 1g
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: H1224
Product name: D-Homoserine
Purity: >96.0%(T)
Packaging: 5g
Price: $254
Updated: 2025/07/31

TRC

Product number: H615123
Product name: D-Homoserine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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D-Homoserine Chemical Properties,Usage,Production

Chemical Properties

White to lightbyellow crystalline powder

Uses

peptide synthesis

Definition

ChEBI: The D-enantiomer of homoserine.

Biochem/physiol Actions

D-Homoserine is used for the synthesis of bacterial polysaccharids such as the O-antigen of Acinetobacter lwoffii EK30A. D-Homoserine is used to produce atypical serine protease(s) for mechanism studies.

Synthesis

348-67-4

6027-21-0

The general procedure for the synthesis of D-homoserine from D-methionine was as follows: D-methionine (1) (25.0 g, 167.5 mmol, 1 eq.) was suspended in a mixed H2O/MeOH solvent (466 mL/66 mL) according to the literature method, followed by the addition of methyl iodide (25.2 mL, 405.4 mmol, 2.4 eq.). The resulting suspension was stirred vigorously at room temperature for 48 hours. Upon completion of the reaction, the volume of the reaction mixture was concentrated to one-third of the original volume by vacuum evaporation, while the excess methyl iodide was removed. To the remaining reaction mixture was added water (155 mL) followed by NaHCO3 (14.07 g, 167.5 mmol, 1 equiv). The resulting solution was refluxed for 15 hours and then cooled to room temperature. The solvent was removed under vacuum to give a thick syrupy substance. The syrupy substance was dissolved in water (45 mL) under heating, followed by sequential addition of acetone (90 mL) and ethanol (1000 mL), and a white solid precipitate was observed. The precipitate was filtered and dried under vacuum to give a white solid of the target product D-homoserine (2). Yield: 9.9 g (83 mmol, 50% yield). Melting point: 202°C. 1H NMR (300 MHz, D2O): δ = 1.92-1.78 (m, 1H, 3-CH), 2.09-2.92 (m, 1H, 3-CH), 3.65-3.58 (m, 2H, 4-CH2), 3.68 (dd, 3JH,H = 4.8, 3JH,H = 7.5 Hz, 1H, 2-CH ).13C NMR (75 MHz, D2O): δ = 32.1 (s, 3-C), 53.3 (s, 2-C), 58.5 (s, 4-C), 174.5 (s, 1-C).HRMS (ESI+, MeOH): m/z = 142.0468 [M + Na]+ with a calculated value of 142.0475 for C4H9NO3Na.

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 19, p. 5168 - 5181
[2] Tetrahedron, 1988, vol. 44, # 2, p. 637 - 642

D-Homoserine Preparation Products And Raw materials

Raw materials

Preparation Products

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D-Homoserine Suppliers

Americas 1 Belgium 1 China 206 Europe 2 Germany 7 India 8 Japan 4 Switzerland 1 United Kingdom 5 United States 33 USA 1 Global 269

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Energy Chemical

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Shanghai Longsheng chemical Co.,Ltd.

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View Lastest Price from D-Homoserine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: D-Homoserine 6027-21-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 5000kg/month
Release date: 2021-10-13

Hebei Fengjia New Material Co., Ltd

Product: D-Homoserine 6027-21-0
Price: US $6.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2024-08-16

Hebei Chuanghai Biotechnology Co., Ltd

Product: D-Homoserine 6027-21-0
Price: US $9.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-05

6027-21-0, D-HomoserineRelated Search:

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Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

amino acids

Pyridines