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AC-YVAD-CMK

Product Name
AC-YVAD-CMK
CAS No.
178603-78-6
Chemical Name
AC-YVAD-CMK
Synonyms
AC-YVAD-CMK;ICE INHIBITOR II;CASPASE-1 INHIBITOR II;AC-TYR-VAL-ALA-ASP-CMK;AC-TYR-VAL-ALA-ASP-CH2CL;N-Ac-Tyr-Val-Ala-Asp-CMK;5-Trihydroxybenzoic acid;Ac-YVAD-cmk >=95% (HPLC);AC-YVAD-CHLOROMETHYLKETONE;AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
CBNumber
CB0168634
Molecular Formula
C24H33ClN4O8
Formula Weight
540.99
MOL File
178603-78-6.mol
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AC-YVAD-CMK Property

Melting point:
>205°C (dec.)
RTECS 
AY3079566
storage temp. 
-20°C
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
form 
White solid
color 
white to off-white
Stability:
Hygroscopic
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0429
Product name
Ac-YVAD-cmk
Purity
≥95% (HPLC)
Packaging
1mg
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
400012
Product name
Caspase-1 Inhibitor II
Packaging
5mg
Price
$390
Updated
2024/03/01
Alfa Aesar
Product number
J64226
Product name
Caspase-1 Inhibitor II
Packaging
5mg
Price
$245
Updated
2021/12/16
Cayman Chemical
Product number
10014
Product name
Ac-YVAD-CMK
Purity
≥98%
Packaging
500μg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
10014
Product name
Ac-YVAD-CMK
Purity
≥98%
Packaging
1mg
Price
$71
Updated
2024/03/01
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AC-YVAD-CMK Chemical Properties,Usage,Production

Uses

Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical]

Uses

Ac-YVAD-cmk has been used:

  • as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
  • as a caspase-1 inhibitor injected to C57BL/6 mice
  • as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
  • to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
  • as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition

General Description

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Biochem/physiol Actions

Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.

AC-YVAD-CMK Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-YVAD-CMK Suppliers

China 92 India 1 Japan 2 Switzerland 2 United Kingdom 4 United States 17 USA 1 Global 119
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Fluorochem Ltd
Tel
--
Fax
--
Email
vernam@fluorochem.co.uk
Country
United Kingdom
ProdList
6375
Advantage
65
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82

178603-78-6, AC-YVAD-CMKRelated Search:

3-AMINO-PENTANOIC ACID HCL AC-YVAD-CHO H-TYR-GLY-NH2 HCL 5-Chlorovaleric acid H-ALA-VAL-NH2 HCL AC-YVAD-CMK BIOTINYLATED AC-YVAD-CMK

  • ICE INHIBITOR II
  • IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR II
  • IL-1BETA CONVERTING ENZYME INHIBITOR II
  • INTERLEUKIN-1BETA (IL-1BETA) CONVERTING ENZYME (ICE) INHIBITOR II
  • CASPASE-1 INHIBITOR (CHLOROMETHYLKETONE)
  • CASPASE-1 INHIBITOR II
  • AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
  • AC-TYR-VAL-ALA-ASP-CH2CL
  • AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE
  • AC-TYR-VAL-ALA-ASP-CMK
  • AC-YVAD-CHLOROMETHYLKETONE
  • AC-YVAD-CMK
  • (ACETYL-L-TYROSYL-L-VALYL-L-ALANYL-L-ASPART-1-YL)CHLOROMETHANE
  • N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KETONE
  • N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-1-(CARBOXYMETHYL)-3-CHLORO-2-OXOPROPYL]-L-ALANINAMIDE
  • interleukin-1B (1L-1B) converting*enzyme (ice) in
  • N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KE
  • interleukin-1β (il-1β) converting enzyme (ice) inhibitor ii
  • INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR II
  • N-Ac-Tyr-Val-Ala-Asp-CMK
  • AC-TYR-VAL-ALA-ASP-CMK ; AC-YVKD-CMK
  • CASPASE 1 INHIBITOR II;AC-YVAD-CMK
  • Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem
  • L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
  • (4S,7S,10S,13S)-13-(2-Chloroacetyl)-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
  • 5-Trihydroxybenzoic acid
  • Ac-YVAD-cmk >=95% (HPLC)
  • 178603-78-6
  • C24H33ClN4O8
  • BioChemical
  • Apoptosis and Cell Cycle
  • Cell Signaling and Neuroscience
  • Caspase 1
  • Caspases
  • Cell Biology
  • Inhibitors
  • Caspase/Related Products
  • peptide
  • Pepetides
  • peptides
  • Elisa Kit-Mouse Elisa Kit