ChemicalBook > CAS DataBase List > Metaxalone

Metaxalone

Product Name: Metaxalone
CAS No.: 1665-48-1
Chemical Name: Metaxalone
Synonyms: Zorane;AHR-438;Skelaxi;NSC2351;cl39,148;SKELAXIN;NSC 2351;NSC-2351;CL 39,148;Metaxalon
CBNumber: CB0175959
Molecular Formula: C12H15NO3
Formula Weight: 221.25
MOL File: 1665-48-1.mol

Less

Metaxalone Property

Melting point:: 121-1230C
Boiling point:: 225°C/1.5mmHg(lit.)
Density: 1.1514 (rough estimate)
refractive index: 1.5200 (estimate)
Flash point:: 9 °C
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: ≥2mg/mL (warmed to 60 °C)
pka: 12.26±0.40(Predicted)
form: powder
color: white to tan
BCS Class: 2
InChIKey: IMWZZHHPURKASS-UHFFFAOYSA-N
CAS DataBase Reference: 1665-48-1(CAS DataBase Reference)
NIST Chemistry Reference: Metaxalone(1665-48-1)
EPA Substance Registry System: 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]- (1665-48-1)

Less

Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3
RTECS: RQ3850000
HS Code: 2934990002
Hazardous Substances Data: 1665-48-1(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3036
Product name: Metaxalone
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $170
Updated: 2025/07/31

Sigma-Aldrich

Product number: M-074
Product name: Metaxalone solution
Purity: 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $169
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1396149
Product name: Metaxalone
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $392
Updated: 2025/07/31

Sigma-Aldrich

Product number: M-143
Product name: Metaxalone-D6 solution
Purity: 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $124
Updated: 2022/05/15

TCI Chemical

Product number: M2578
Product name: Metaxalone
Purity: >98.0%(GC)
Packaging: 1g
Price: $39
Updated: 2025/07/31

Less

Metaxalone Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Originator

Skelaxin,Robins,US,1962

Uses

It is a muscle relaxant used to relax muscles and relieve pain

Uses

muscle relaxant (skeletal)

Uses

For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.

Uses

Metaxalone is a skeletal muscle relaxant that has applications in reducing muscle spasm, limitations in normal motion, and pain caused by musculoskeletal conditions. It is commonly used in combination with analgesics to address low back pain. The molecular or cellular actions of metaxalone is not known.[Cayman Chemical]

Definition

ChEBI: Metaxalone is an aromatic ether.

Manufacturing Process

Urea (118 g, 1.96 mols) was added to 192 g (0.98 mol) of 3-(3',5'- dimethylphenoxy)-1,2-propane-diol which had previously been heated to 150°C. The reaction mixture was then heated rapidly to 195° to 200°C and maintained at this temperature for 5 hours with constant stirring. The resulting mixture was partitioned between water and ethyl acetate and the ethyl acetate layer was dried over sodium sulfate and concentrated. The residue was distilled in vacuo and the fraction boiling at 220° to 225°C/1.5 mm was collected. Yield, 172 g (79%). The distillate was crystallized from dry ethyl acetate; MP, 121.5° to 123°C.

Therapeutic Function

Muscle relaxant

Biological Activity

Metaxalone is a muscle relaxant. The mechanism of action of metaxalone in humans is not fully understood. It was suggested th at it acts through general central nervous system depression. ', 'Metaxalone is effective to relieve pain due to acute skeletal muscle pain caused due to musculoskeletal conditions and sprains.

References

[1] Patent: US2007/185177, 2007, A1. Location in patent: Page/Page column 8

Metaxalone Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Metaxalone Suppliers

Americas 1 Canada 3 China 169 Europe 3 Germany 1 India 25 Italy 4 Japan 1 South Korea 1 United Kingdom 4 United States 34 Global 246

Nanjing LuoDa Chemical Co., Ltd

Tel: 025-66016961 13382082786
Fax: 025-52204547
Country: China
ProdList: 222
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD.

Tel: 86-029-85456576
Fax: 86-029-85456576-808
Email: daisy_wang@vip.163.com
Country: China
ProdList: 292
Advantage: 55

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4447
Advantage: 55

Weifang QianJin Fine Chemical Co., Ltd.

Tel: 18753684562
Fax: 0536-8897109
Email: 1577399715@qq.COM
Country: China
ProdList: 1735
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 17801761073
Email: 3193328036@qq.com
Country: China
ProdList: 6338
Advantage: 68

Shenzhen Simeiquan Biotechnology Co. Ltd

Tel: 18126413629 0755-23311925 2355327053
Fax: 0755-23311925
Email: abel@ycgmp.com
Country: China
ProdList: 5113
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shenzhen Sendi Biological Technology Co., Ltd.

Tel: 18124570582 TEL：0755-23574479 2355327139
Fax: 0755-23229476 QQ: 2355327139
Email: siliao02@yccreate.com
Country: China
ProdList: 6116
Advantage: 58

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1997
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3931
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Shenzhen Newcore Chemical Technology Co., Ltd.

Tel: 13612807752
Email: ncchemical@163.com
Country: China
ProdList: 290
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83778895 18602735115
Fax: 027-51119224
Email: 18602735115@163.com
Country: China
ProdList: 2005
Advantage: 64

Foshan DaoQi Biological Co., Ltd.

Tel: 18062666947
Fax: 18062666959
Email: 2355880548@qq.com
Country: China
ProdList: 4228
Advantage: 58

Henan Alfachem Co.,Ltd.

Tel: 0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9988
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd.

Tel: 029-88380327 17691182729
Fax: 029-88380327
Email: 1018@dideu.com
Country: China
ProdList: 2011
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Less

View Lastest Price from Metaxalone manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Metaxalone 1665-48-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-05-09

Shaanxi Dideu New Materials Co. Ltd

Product: Metaxalone 1665-48-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: Metaxalone 1665-48-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

1665-48-1, MetaxaloneRelated Search:

Bensulfuron methyl Nabumetone Methylparaben Diethoxydimethylsilane N,N-Dimethyldodecylamine Linezolid Poly(dimethylsiloxane) Dimethyldimethoxysilane Dimethyl sulfoxide N,N-Dimethylformamide Methyl acetate Kresoxim-methyl Chlormezanone METSULFURON METHYL Methyl salicylate Metandienone Thiophanate-methyl Methyl

5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one

2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-

2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-

5-((3,5-dimethylphenoxy)methyl)-2-oxazolidinon

5-((3,5-Dimethylphenoxy)methyl)-2-oxazolidinone

5-((3,5-xylyloxy)methyl)-2-oxazolidinon

5-((3,5-Xylyloxy)methyl)-2-oxazolidinone

5-(3,5-Xyloloxymethyl)oxazolidin-2-one

5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one

AHR-438

CL 39,148

cl39,148

Metaxalon

Metazalone

Metazolone

Methaxalonum

Methoxolone

Zorane

5-(3,5-xylyloxymethyl)-2-oxazolidone

Metaxalowe

METAXALONE

METAXALONE-D6

METAXOLONE

SKELAXIN

METAXALONE 99.0%

Metaxolene(DCPDAcetate)

Skelaxi

5-[(3,5-Dimethylphenoxy)methyl]oxazolidin-2-one-d6

AHR-438-d6

Skelaxin-d

5-(3,5-Dimethylphenoxy)methyl-2-Oxazolidinone(Metaxalone)

Skelaxin-d6

Metaxalone solution

NSC 170959

Metaxalone-D6 solution

Metaxalone (200 mg)

(5R)-5-(3,5-diMethylphenoxyMethyl)-1,3-oxazolidin-2-one

Metaxalone-D

AHR438;NSC170959;SKELAXIN

Metaxalone &gt

Metaxalone USP/EP/BP

Metaxalone (AHR438

MetaxaloneQ: What is Metaxalone Q: What is the CAS Number of Metaxalone Q: What is the storage condition of Metaxalone Q: What are the applications of Metaxalone

Metaxalone (1396149)

NSC 2351

NSC2351

NSC-2351

Beauty he methadone

Methaxadone

Metaxalone, ≥ 98.0%

Skelaxin|||Methaxalonum|||Zorane|||NSC170959|||AHR438

Metaxalone, 10 mM in DMSO

1665-48-1

1665-45-1

C12H9D6NO3

SKELAXON

Various Metabolites and Impurities

Metabolites & Impurities