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Metaxalone

Product Name
Metaxalone
CAS No.
1665-48-1
Chemical Name
Metaxalone
Synonyms
Zorane;AHR-438;Skelaxi;NSC2351;cl39,148;SKELAXIN;NSC 2351;NSC-2351;CL 39,148;Metaxalon
CBNumber
CB0175959
Molecular Formula
C12H15NO3
Formula Weight
221.25
MOL File
1665-48-1.mol
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Metaxalone Property

Melting point:
121-1230C
Boiling point:
225°C/1.5mmHg(lit.)
Density 
1.1514 (rough estimate)
refractive index 
1.5200 (estimate)
Flash point:
9 °C
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: ≥2mg/mL (warmed to 60 °C)
pka
12.26±0.40(Predicted)
form 
powder
color 
white to tan
BCS Class
2
InChIKey
IMWZZHHPURKASS-UHFFFAOYSA-N
CAS DataBase Reference
1665-48-1(CAS DataBase Reference)
NIST Chemistry Reference
Metaxalone(1665-48-1)
EPA Substance Registry System
2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]- (1665-48-1)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
RQ3850000
HS Code 
2934990002
Hazardous Substances Data
1665-48-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3036
Product name
Metaxalone
Purity
pharmaceutical secondary standard, certified reference material
Packaging
500MG
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
M-074
Product name
Metaxalone solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$166
Updated
2024/03/01
Sigma-Aldrich
Product number
1396149
Product name
Metaxalone
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$174.4
Updated
2024/03/01
Sigma-Aldrich
Product number
M-143
Product name
Metaxalone-D6 solution
Purity
100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$124
Updated
2022/05/15
TCI Chemical
Product number
M2578
Product name
Metaxalone
Purity
>98.0%(GC)
Packaging
1g
Price
$39
Updated
2024/03/01
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Metaxalone Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Originator

Skelaxin,Robins,US,1962

Uses

It is a muscle relaxant used to relax muscles and relieve pain

Uses

muscle relaxant (skeletal)

Uses

For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.

Uses

Metaxalone is a skeletal muscle relaxant that has applications in reducing muscle spasm, limitations in normal motion, and pain caused by musculoskeletal conditions. It is commonly used in combination with analgesics to address low back pain. The molecular or cellular actions of metaxalone is not known.[Cayman Chemical]

Definition

ChEBI: Metaxalone is an aromatic ether.

Manufacturing Process

Urea (118 g, 1.96 mols) was added to 192 g (0.98 mol) of 3-(3',5'- dimethylphenoxy)-1,2-propane-diol which had previously been heated to 150°C. The reaction mixture was then heated rapidly to 195° to 200°C and maintained at this temperature for 5 hours with constant stirring. The resulting mixture was partitioned between water and ethyl acetate and the ethyl acetate layer was dried over sodium sulfate and concentrated. The residue was distilled in vacuo and the fraction boiling at 220° to 225°C/1.5 mm was collected. Yield, 172 g (79%). The distillate was crystallized from dry ethyl acetate; MP, 121.5° to 123°C.

Therapeutic Function

Muscle relaxant

Metaxalone Preparation Products And Raw materials

Raw materials

Preparation Products

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Metaxalone Suppliers

TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from Metaxalone manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Metaxalone 1665-48-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Metaxalone 1665-48-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
Metaxalone 1665-48-1
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-22

1665-48-1, MetaxaloneRelated Search:


  • 5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one
  • 2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-
  • 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-
  • 5-((3,5-dimethylphenoxy)methyl)-2-oxazolidinon
  • 5-((3,5-Dimethylphenoxy)methyl)-2-oxazolidinone
  • 5-((3,5-xylyloxy)methyl)-2-oxazolidinon
  • 5-((3,5-Xylyloxy)methyl)-2-oxazolidinone
  • 5-(3,5-Xyloloxymethyl)oxazolidin-2-one
  • 5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
  • AHR-438
  • CL 39,148
  • cl39,148
  • Metaxalon
  • Metazalone
  • Metazolone
  • Methaxalonum
  • Methoxolone
  • Zorane
  • 5-(3,5-xylyloxymethyl)-2-oxazolidone
  • Metaxalowe
  • METAXALONE
  • METAXALONE-D6
  • METAXOLONE
  • SKELAXIN
  • METAXALONE 99.0%
  • Metaxolene(DCPDAcetate)
  • Skelaxi
  • 5-[(3,5-Dimethylphenoxy)methyl]oxazolidin-2-one-d6
  • AHR-438-d6
  • Skelaxin-d
  • 5-(3,5-Dimethylphenoxy)methyl-2-Oxazolidinone(Metaxalone)
  • Skelaxin-d6
  • Metaxalone solution
  • NSC 170959
  • Metaxalone-D6 solution
  • Metaxalone (200 mg)
  • (5R)-5-(3,5-diMethylphenoxyMethyl)-1,3-oxazolidin-2-one
  • Metaxalone-D
  • AHR438;NSC170959;SKELAXIN
  • Metaxalone &gt
  • Metaxalone USP/EP/BP
  • Metaxalone (AHR438
  • MetaxaloneQ: What is Metaxalone Q: What is the CAS Number of Metaxalone Q: What is the storage condition of Metaxalone Q: What are the applications of Metaxalone
  • Metaxalone (1396149)
  • NSC 2351
  • NSC2351
  • NSC-2351
  • Beauty he methadone
  • Methaxadone
  • Metaxalone, ≥ 98.0%
  • Skelaxin|||Methaxalonum|||Zorane|||NSC170959|||AHR438
  • 1665-48-1
  • 1665-45-1
  • C12H9D6NO3
  • SKELAXON
  • Various Metabolites and Impurities
  • Metabolites & Impurities
  • Isotope Labeled Compounds