Metaxalone

Product Name: Metaxalone
CAS No.: 1665-48-1
Chemical Name: Metaxalone
Synonyms: Zorane;AHR-438;Skelaxi;NSC2351;cl39,148;SKELAXIN;NSC 2351;NSC-2351;CL 39,148;Metaxalon
CBNumber: CB0175959
Molecular Formula: C12H15NO3
Formula Weight: 221.25
MOL File: 1665-48-1.mol

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Metaxalone Property

Melting point:: 121-1230C
Boiling point:: 225°C/1.5mmHg(lit.)
Density: 1.1514 (rough estimate)
refractive index: 1.5200 (estimate)
Flash point:: 9 °C
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: ≥2mg/mL (warmed to 60 °C)
pka: 12.26±0.40(Predicted)
form: powder
color: white to tan
BCS Class: 2
InChIKey: IMWZZHHPURKASS-UHFFFAOYSA-N
CAS DataBase Reference: 1665-48-1(CAS DataBase Reference)
NIST Chemistry Reference: Metaxalone(1665-48-1)
EPA Substance Registry System: 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]- (1665-48-1)

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3
RTECS: RQ3850000
HS Code: 2934990002
Hazardous Substances Data: 1665-48-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3036
Product name: Metaxalone
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $173
Updated: 2024/03/01

Sigma-Aldrich

Product number: M-074
Product name: Metaxalone solution
Purity: 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $166
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1396149
Product name: Metaxalone
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $174.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: M-143
Product name: Metaxalone-D6 solution
Purity: 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $124
Updated: 2022/05/15

TCI Chemical

Product number: M2578
Product name: Metaxalone
Purity: >98.0%(GC)
Packaging: 1g
Price: $39
Updated: 2024/03/01

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Metaxalone Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Originator

Skelaxin,Robins,US,1962

Uses

It is a muscle relaxant used to relax muscles and relieve pain

Uses

muscle relaxant (skeletal)

Uses

For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.

Uses

Metaxalone is a skeletal muscle relaxant that has applications in reducing muscle spasm, limitations in normal motion, and pain caused by musculoskeletal conditions. It is commonly used in combination with analgesics to address low back pain. The molecular or cellular actions of metaxalone is not known.[Cayman Chemical]

Definition

ChEBI: Metaxalone is an aromatic ether.

Manufacturing Process

Urea (118 g, 1.96 mols) was added to 192 g (0.98 mol) of 3-(3',5'- dimethylphenoxy)-1,2-propane-diol which had previously been heated to 150°C. The reaction mixture was then heated rapidly to 195° to 200°C and maintained at this temperature for 5 hours with constant stirring. The resulting mixture was partitioned between water and ethyl acetate and the ethyl acetate layer was dried over sodium sulfate and concentrated. The residue was distilled in vacuo and the fraction boiling at 220° to 225°C/1.5 mm was collected. Yield, 172 g (79%). The distillate was crystallized from dry ethyl acetate; MP, 121.5° to 123°C.

Therapeutic Function

Muscle relaxant

Metaxalone Preparation Products And Raw materials

Raw materials

Preparation Products

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Metaxalone Suppliers

Americas 1 Canada 3 China 143 Europe 3 Germany 1 India 24 Italy 4 Japan 1 South Korea 1 United Kingdom 4 United States 35 Global 220

Nanjing LuoDa Chemical Co., Ltd

Tel: 025-66016961 13382082786
Fax: 025-52204547
Country: China
ProdList: 289
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

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View Lastest Price from Metaxalone manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Metaxalone 1665-48-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Metaxalone 1665-48-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: Metaxalone 1665-48-1
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-22

1665-48-1, MetaxaloneRelated Search:

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5-[(3,5-dimethylphenoxy)methyl]oxazolidin-2-one

2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-

2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]-

5-((3,5-dimethylphenoxy)methyl)-2-oxazolidinon

5-((3,5-Dimethylphenoxy)methyl)-2-oxazolidinone

5-((3,5-xylyloxy)methyl)-2-oxazolidinon

5-((3,5-Xylyloxy)methyl)-2-oxazolidinone

5-(3,5-Xyloloxymethyl)oxazolidin-2-one

5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one

AHR-438

CL 39,148

cl39,148

Metaxalon

Metazalone

Metazolone

Methaxalonum

Methoxolone

Zorane

5-(3,5-xylyloxymethyl)-2-oxazolidone

Metaxalowe

METAXALONE

METAXALONE-D6

METAXOLONE

SKELAXIN

METAXALONE 99.0%

Metaxolene(DCPDAcetate)

Skelaxi

5-[(3,5-Dimethylphenoxy)methyl]oxazolidin-2-one-d6

AHR-438-d6

Skelaxin-d

5-(3,5-Dimethylphenoxy)methyl-2-Oxazolidinone(Metaxalone)

Skelaxin-d6

Metaxalone solution

NSC 170959

Metaxalone-D6 solution

Metaxalone (200 mg)

(5R)-5-(3,5-diMethylphenoxyMethyl)-1,3-oxazolidin-2-one

Metaxalone-D

AHR438;NSC170959;SKELAXIN

Metaxalone &gt

Metaxalone USP/EP/BP

Metaxalone (AHR438

MetaxaloneQ: What is Metaxalone Q: What is the CAS Number of Metaxalone Q: What is the storage condition of Metaxalone Q: What are the applications of Metaxalone

Metaxalone (1396149)

NSC 2351

NSC2351

NSC-2351

Beauty he methadone

Methaxadone

Metaxalone, ≥ 98.0%

Skelaxin|||Methaxalonum|||Zorane|||NSC170959|||AHR438

1665-48-1

1665-45-1

C12H9D6NO3

SKELAXON

Various Metabolites and Impurities

Metabolites & Impurities

Isotope Labeled Compounds