Veratric Acid
- Product Name
- Veratric Acid
- CAS No.
- 93-07-2
- Chemical Name
- Veratric Acid
- Synonyms
- VERATRIC ACID;NSC 7721;AKOS 220-15;reratric acid;VERATRIC ACID(RG);AKOS BBS-00003717;Veratrumenoic acid;Veratric acid (8CI);RARECHEM AL BO 0042;DiMethoxybenzoic aci
- CBNumber
- CB0176264
- Molecular Formula
- C9H10O4
- Formula Weight
- 182.17
- MOL File
- 93-07-2.mol
Veratric Acid Property
- Melting point:
- 179-182 °C(lit.)
- Boiling point:
- 275.56°C (rough estimate)
- Density
- 1.2481 (rough estimate)
- refractive index
- 1.4500 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- 0.5g/l
- pka
- 4.35±0.10(Predicted)
- form
- Crystalline Powder
- color
- Almost white to beige or reddish
- Water Solubility
- slightly soluble
- Merck
- 14,9953
- BRN
- 518285
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- DAUAQNGYDSHRET-UHFFFAOYSA-N
- LogP
- 1.610
- CAS DataBase Reference
- 93-07-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzoic acid, 3,4-dimethoxy-(93-07-2)
- EPA Substance Registry System
- Benzoic acid, 3,4-dimethoxy- (93-07-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- DG8598750
- TSCA
- Yes
- HS Code
- 29189090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D131806
- Product name
- 3,4-Dimethoxybenzoic acid
- Purity
- ≥99%
- Packaging
- 100g
- Price
- $86.7
- Updated
- 2024/03/01
- Product number
- 8.45140
- Product name
- 3,4-Dimethoxybenzoic acid
- Purity
- Msynth?plus
- Packaging
- 250G
- Price
- $179
- Updated
- 2022/05/15
- Product number
- 8.45140
- Product name
- 3,4-Dimethoxybenzoic acid
- Purity
- Msynth?plus
- Packaging
- 1KG
- Price
- $575
- Updated
- 2022/05/15
- Product number
- D0631
- Product name
- 3,4-Dimethoxybenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $29
- Updated
- 2024/03/01
- Product number
- D0631
- Product name
- 3,4-Dimethoxybenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 500g
- Price
- $197
- Updated
- 2024/03/01
Veratric Acid Chemical Properties,Usage,Production
Description
Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits and has antioxidant and anti-inflammatory activities. It also acts as a protective agent against hypertension-associated cardiovascular remodeling. Veratric acid reduces upregulated COX-2 expression and levels of PGE2 and IL-6 after UVB irradiation. This compound could be reduced to veratrine aldehyde, and alcohol was performed with enzyme extracts from a wood-degrading basidiomycete, Polystictus (Trametes) versicolor[1].
Chemical Properties
white to slightly yellow powder
Uses
3,4-Dimethoxybenzoic acid plays an important role in producing antibiotics and various dyes. They are used as intermediates for pharmaceuticals (especially for antipyretic analgesic, antirheumatism) and other organic synthesis. It is used as matrix for ionization of peptides, proteins and carbohydrates.
Uses
3,4-Dimethoxybenzoic acid is a derivative of Protocatechuic Acid.3,4-Dimethoxybenzoic acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.
Definition
ChEBI: A member of the class of benzoic acids that is benzoic acid substituted by methoxy groups at positions 2 and 3.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 26, p. 299, 1978 DOI: 10.1248/cpb.26.299
Tetrahedron Letters, 43, p. 4985, 2002 DOI: 10.1016/S0040-4039(02)00929-2
in vitro
Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation, and HDAC3 expression in RAW264.7 cells.
Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis.
Veratric acid reduces upregulated COX-2 expression and levels of PGE2, and IL-6 after UVB irradiation.
Purification Methods
Crystallise the acid from Et2O, H2O or aqueous acetic acid. It has m 180-181o after sublimation at 80o/1mm. [Beilstein 10 H 393, 10 I 188, 10 II 261, 10 III 1404, 10 IV 1406.]
References
[1] Gross, Georg G. “From lignins to tannins: Forty years of enzyme studies on the biosynthesis of phenolic compounds.” Phytochemistry 69 18 (2008): Pages 3018-3031.
Veratric Acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from Veratric Acid manufacturers
- Product
- 3,4-Dimethoxybenzoic acid 93-07-2
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2024-05-14
- Product
- 3,4-Dimethoxybenzoic acid 93-07-2
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100mt/year
- Release date
- 2021-07-08
- Product
- 3,4-Dimethoxybenzoic acid 93-07-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-10-31