2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID
Uses- Product Name
- 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID
- CAS No.
- 149353-95-7
- Chemical Name
- 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID
- Synonyms
- 2-Boc-1,2,3,4-tetrahydro-...;7-Isoquinolinecarboxylicacid-N-tertbutylester;2-boc-7-carboxyl-1,2,3,4-tetrahydroisoquinoline;2-Boc-1,2,3,4-Tetrahydroisoquinoline-7-Carboxylic Acid;N-BOC-7-HYDROXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE;N-Boc-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid;2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CAR...;2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic;3,4-DIHYDRO-1H-ISOQUINOLINE-2,7-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER;2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID
- CBNumber
- CB0179801
- Molecular Formula
- C15H19NO4
- Formula Weight
- 277.32
- MOL File
- 149353-95-7.mol
2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID Property
- Melting point:
- 151-153 °C
- Boiling point:
- 429.3±45.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.37±0.20(Predicted)
- Appearance
- Light brown to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T205255
- Product name
- 2-(Tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-7-CarboxylicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T205255
- Product name
- 2-(Tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinoline-7-CarboxylicAcid
- Packaging
- 500mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- FB140853
- Product name
- 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid
- Packaging
- 500mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- FB140853
- Product name
- 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid
- Packaging
- 50mg
- Price
- $54
- Updated
- 2021/12/16
- Product number
- 112845
- Product name
- 2-Boc-1,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid
- Packaging
- 1g
- Price
- $235
- Updated
- 2021/12/16
2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
2-BOC-7-carboxy-1,2,3,4-tetrahydroisoquinoline is a quinoline derivative used in pharmaceutical synthesis and experimental research.
Synthesis
960305-54-8
149353-95-7
2-tert-butyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate (450 mg, 1.545 mmol) was used as a raw material and dissolved in tetrahydrofuran (THF, 2 mL) and methanol (MeOH, 1 mL). Lithium hydroxide (LiOH, 111 mg, 4.63 mmol) and water (H2O, 1 mL) were added. The reaction mixture was heated to 60 °C and stirred at this temperature for 3 hours. Upon completion of the reaction, the solvent was evaporated until the remaining predominantly aqueous layer. The aqueous layer was cooled in an ice bath and adjusted to slightly acidic by slowly adding 5 M hydrochloric acid (HCl) dropwise. Extraction was performed with ethyl acetate (EtOAc, 10 mL) and water (H2O, 10 mL). The aqueous layer was again extracted with ethyl acetate (10 mL). The organic layers were combined, dried and concentrated to give a colorless oil, which was solidified overnight under reduced pressure. The resulting solid precipitate was ground in methyl tert-butyl ether (MTBE), filtered and dried to afford 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid (260 mg, 58.3% yield).LC/MS m/z = 278.2 [M + H]+; 1H NMR (400 MHz, DMSO-d6) δ ppm 1.43 (s , 9H), 2.83 (t, J = 5.87 Hz, 2H), 3.56 (t, J = 5.94 Hz, 2H), 4.55 (s, 2H), 7.28 (d, J = 7.96 Hz, 1H), 7.70-7.75 (m, 2H), 12.84 (br s, 1H).
References
[1] Patent: WO2013/70657, 2013, A1. Location in patent: Page/Page column 153; 175
[2] Patent: US2010/234340, 2010, A1. Location in patent: Page/Page column 63
2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID Suppliers
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- Product
- 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-CARBOXYLIC ACID 149353-95-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2020-10-28