ChemicalBook > CAS DataBase List > 7-Fluoroisatin

7-Fluoroisatin

Product Name
7-Fluoroisatin
CAS No.
317-20-4
Chemical Name
7-Fluoroisatin
Synonyms
7-FLUOROINDOLINE-2,3-DIONE;1H-Indole-2,3-dione, 7-fluoro-;7-FL;7-FLUOROISATIN;7-Flouroisatin;7-Fluoroisation;7-FLUOROISATINE;7- fluorineisatin;BUTTPARK 24\07-37;7-Fluoroisatin>
CBNumber
CB0181767
Molecular Formula
C8H4FNO2
Formula Weight
165.12
MOL File
317-20-4.mol
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7-Fluoroisatin Property

Melting point:
192-196°C
Density 
1.477±0.06 g/cm3(Predicted)
storage temp. 
Store at room temperature
pka
8.44±0.20(Predicted)
form 
powder to crystal
color 
Light yellow to Brown
Water Solubility 
Sparingly Soluble in water (0.022 g/L)
InChI
InChI=1S/C8H4FNO2/c9-5-3-1-2-4-6(5)10-8(12)7(4)11/h1-3H,(H,10,11,12)
InChIKey
HGBGVEOXPHGSOS-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2F)C(=O)C1=O
CAS DataBase Reference
317-20-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-43
Safety Statements 
37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
679119
Product name
7-Fluoroisatin
Purity
96%
Packaging
5g
Price
$146
Updated
2025/07/31
TCI Chemical
Product number
F0551
Product name
7-Fluoroisatin
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$83
Updated
2025/07/31
TCI Chemical
Product number
F0551
Product name
7-Fluoroisatin
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$300
Updated
2025/07/31
TRC
Product number
F592278
Product name
7-Fluoroindoline-2,3-dione
Packaging
1g
Price
$55
Updated
2021/12/16
TRC
Product number
F592278
Product name
7-Fluoroindoline-2,3-dione
Packaging
2.5g
Price
$65
Updated
2021/12/16
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7-Fluoroisatin Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

7-Fluoroisatin is used as the intermediate of cardiovascular, anti-inflammatory and bactericidal drugs.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 10, p. 23, 2004
Tetrahedron Letters, 35, p. 7303, 1994 DOI: 10.1016/0040-4039(94)85299-5

Synthesis

349-24-6

317-20-4

Step 2: 7-fluoroindoline-2,3-dione N-(2-fluorophenyl)-2-(hydroxyimino)acetamide (30 g, 164.84 mmol) was dissolved in concentrated sulfuric acid (100 mL), and the reaction was stirred at 80 °C for 2 hours. Upon completion of the reaction, the mixture was slowly poured into an ice-water mixture, and the precipitated brick-red solid was collected by filtration and dried to give 25 g of 7-fluorodihydroindole-2,3-dione in 90% yield. The product was analyzed by LCMS to confirm that the molecular ion peak was 166 (M + H)+.

References

[1] Patent: US2008/139558, 2008, A1. Location in patent: Page/Page column 55
[2] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 7, p. 2151 - 2163
[3] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1958, vol. 148, p. 481,488
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 11, p. 2085 - 2094
[5] European Journal of Medicinal Chemistry, 1994, vol. 29, # 10, p. 743 - 751

7-Fluoroisatin Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Fluoroisatin Suppliers

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View Lastest Price from 7-Fluoroisatin manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
7-Fluoroisatin 317-20-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-08-19
Hebei Chuanghai Biotechnology Co., Ltd
Product
7-Fluoroisatin 317-20-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-07
Shaanxi Dideu Medichem Co. Ltd
Product
7-Fluoroisatin 317-20-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20T
Release date
2024-05-22

317-20-4, 7-FluoroisatinRelated Search:

7-Fluoro-6-Methyl Isatin 7-Fluoroisatin 7-Fluoro-5-Methyl Isatin 6-FLUOROISATIN 5-FLUOROISATIN 6-FLUOROINDOLE-3-CARBOXALDEHYDE 5-FLUOROINDOLE-3-CARBOXALDEHYDE 7-Fluoro-4-Methyl Isatin Isatin 7-Fluoroindole Indole 4-FLUOROINDOLE-3-CARBOXALDEHYDE 6-Chloro-7-fluoro-1H-indole-2,3-dione 6,7-DIFLUOROINDOLINE-2,3-DIONE 4,7-DIFLUOROISATIN 5-BROMO-7-FLUOROISATIN 5,7-DIFLUORO ISATIN 5,6,7-trifluoro-1H-indole-2,3-dione

  • 7-fluoromethylisatin
  • 7-fluoro-2,3-dihydro-1H-indole-2,3-dione
  • 7-Fluoro-2,3-dihydro-1H-indol-2,3-dione
  • 7-Fluoroindolin-2,3-dione, 7-Fluoro-1H-indole-2,3-dione
  • 7- fluorineisatin
  • 1H-Indole-2,3-dione, 7-fluoro-
  • 7-Fluoroisation
  • Indole-2,3-dione, 7-fluoro-
  • 7-fluoroindole-1h-2,3-dione
  • 7-FLUOROINDOLE-2,3-DIONE
  • 7-FLUOROINDOLINE-2,3-DIONE
  • 7-FLUOROISATIN
  • 7-FLUOROISATINE
  • 7-FLUORO-1H-INDOLE-2,3-DIONE
  • BUTTPARK 24\07-37
  • 5-(TRIFLUOROMETHYL) ISTATIN
  • 7-Fluoro-2,3-indolinedione
  • 7-FLUOROINDOLE-3-CARBOXALDEHYDE
  • 7-FL
  • 7-Fluoroisatin&gt
  • 7-Flouroisatin
  • 7-Fluoro-1H-indol-2,3-dione
  • 317-20-4
  • 5696-44-0
  • Indoles
  • Simple Indoles
  • intermediates
  • Indane/Indanone and Derivatives
  • Indoles
  • Simple Indoles