2-Amino-4-phenylbutane Property

Melting point:

-50°C

Boiling point:

228-232 °C (lit.)

Density 

0.922 g/mL at 25 °C (lit.)

vapor pressure 

10.146Pa at 25℃

refractive index 

n20/D 1.514(lit.)

Flash point:

208 °F

storage temp. 

−20°C

solubility 

soluble in Chloroform, Ethyl Acetate

form 

liquid

pka

pKa 10.0 (Uncertain)

Specific Gravity

0.922

color 

Clear

PH

11.6 (10g/l, H2O, 20℃)

Water Solubility 

8.5 g/L (20 ºC)

Sensitive 

Air Sensitive

BRN 

2413110

LogP

2.12

CAS DataBase Reference

22374-89-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzenepropanamine, «alpha»-methyl-(22374-89-6)

Safety

Hazard Codes 

C,Xi,T,F

Risk Statements 

34-22-39/23/24/25-23/24/25-11

Safety Statements 

26-36/37/39-45-28A-36/37

RIDADR 

UN 2735 8/PG 3

WGK Germany 

2

RTECS 

UI3920000

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

III

HS Code 

29214980

Toxicity

LD orl-rat: >600 mg/kg AEPPAE 195,647,1940

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-Amino-4-phenylbutane Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Uses

2-Amino-4-phenylbutane is used in the synthesis of N-substituted derivatives of (1-methyl-3- phenylpropyl)amine.

Biological Functions

Amphetamine is an indirectly acting adrenomimetic amine that depends for its action on the release of norepinephrine from noradrenergic nerves. Its pharmacological effects are similar to those of ephedrine; however, its CNS stimulant activity is somewhat greater. Both systolic and diastolic blood pressures are increased by oral dosing with amphetamine. The heart rate is frequently slowed reflexively. Cardiac output may remain unchanged in the low- and moderate-dose range. The therapeutic uses of amphetamine are based on its ability to stimulate the CNS. The D-isomer (dextroamphetamine) is three to four times as potent as the L-isomer in producing CNS effects. It has been used in the treatment of obesity because of its anorexic effect, although tolerance to this effect develops rapidly. It prevents or overcomes fatigue and has been used as a CNS stimulant. Amphetamine is no longer recommended for these uses because of its potential for abuse. Amphetamine is useful in certain cases of narcolepsy or minimal brain dysfunction.

Flammability and Explosibility

Not classified

Safety Profile

A poison by intraperitoneal and parenteral route. Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors of NOx.

Synthesis

Amphetamine is prepared by treating phenylacetone with formic acid and ammonia under the Leuckart-Wallach conditions .