ChemicalBook > CAS DataBase List > MG-115

MG-115

Product Name
MG-115
CAS No.
133407-86-0
Chemical Name
MG-115
Synonyms
MG-115;Z-LLnV;(S)-MG115;Z-LL-NVA-CHO;MG115, Z-LLnV;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;z-leu-leu-norvalinal;Z-LEU-LEU-NVA-ALDEHYDE;MG-115 (DMSO solution)
CBNumber
CB0195607
Molecular Formula
C25H39N3O5
Formula Weight
461.59
MOL File
133407-86-0.mol
More
Less

MG-115 Property

Boiling point:
678.8±55.0 °C(Predicted)
Density 
1.082±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
powder
pka
11.14±0.46(Predicted)
color 
white
InChIKey
WVUWUETVYUPHEM-FKBYEOEOSA-N
SMILES
C(N)(=O)[C@H](CC(C)C)N(C(=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)[C@H](C=O)CCC
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
474780
Product name
MG-115
Purity
Potent reversible proteasome inhibitor (K
Packaging
5mg
Price
$266
Updated
2025/07/31
Sigma-Aldrich
Product number
C6706
Product name
Z-Leu-Leu-Norvalinal
Purity
≥90% (HPLC), powder
Packaging
1mg
Price
$99.3
Updated
2023/06/20
Cayman Chemical
Product number
15413
Product name
(S)-MG115
Purity
≥95%
Packaging
1mg
Price
$51
Updated
2024/03/01
Cayman Chemical
Product number
15413
Product name
(S)-MG115
Purity
≥95%
Packaging
5mg
Price
$128
Updated
2024/03/01
Cayman Chemical
Product number
15413
Product name
(S)-MG115
Purity
≥95%
Packaging
10mg
Price
$229
Updated
2024/03/01
More
Less

MG-115 Chemical Properties,Usage,Production

Description

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

Uses

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]

Uses

MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

Definition

ChEBI: N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester is a peptide.

General Description

Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Biochem/physiol Actions

Product does not compete with ATP.

References

1. involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. imamura, t., haruta, t., takata, y., usui, i., iwata, m., ishihara, h., ishiki, m., ishibashi, o., ueno, e., sasaoka, t., kobayashi, m. j. biol. chem. (1998)

MG-115 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

MG-115 Suppliers

China 91 Germany 2 Japan 3 Switzerland 2 United Kingdom 3 United States 15 USA 1 Global 117
Shanghai Fine Biotech Co.，Ltd
Tel
18221172427
Email
sale@fine-biotech.com
Country
China
ProdList
2753
Advantage
58
Alabiochem Tech.Co., Ltd.
Tel
512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
970
Advantage
59
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-846993838003-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
3249
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
9998
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
7408
Advantage
58
Alpha Biopharmaceuticals Co., Ltd
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Shanghai TenSus Biotechnology Co., Ltd.
Tel
021-50895067 18616507272
Fax
021-50895067
Email
tensus@163.com
Country
China
ProdList
8073
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai Puluokai Medical Technology Co., LTD
Tel
17269768198
Fax
QQ:1213744847
Email
prochemx@163.com
Country
China
ProdList
613
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Email
2853979819@qq.com
Country
China
ProdList
9998
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
2998
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
6979
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2742
Advantage
58
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.
Tel
0571-85350119 15888826472
Email
15888826472@163.com
Country
China
ProdList
2729
Advantage
58
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 086-15871494362 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
6762
Advantage
58
Wuhan Acumen Bio-Technology Co.,ltd
Tel
027-027-16602739303 16602739303
Email
673003916@qq.com
Country
China
ProdList
2935
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Hangzhou Beiputai Biopharmaceutical Co., Ltd
Tel
0571-85350119 15888826472
Email
bptsales@163.com
Country
China
ProdList
3834
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
Tel
025-58851090 17714375163
Email
2881759498@qq.com
Country
China
ProdList
13011
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Merck Millipore
Tel
1-400-889-1988 400-889-1988
Email
bioscience@merckgroup.com
Country
China
ProdList
6839
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Enzo Biochem Inc
Tel
Enzo Biochem Inc. 13797054060
Email
Enzoname@qq.com
Country
China
ProdList
6174
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Selleck Chemicals
Tel
400-668-6834
Email
info@selleck.cn
Country
China
ProdList
6071
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Shanghai Weijiahe Biotechnology Co., Ltd
Tel
17502176150
Email
861873257@qq.com
Country
China
ProdList
1654
Advantage
58
Shanghai Zhuyan Biotechnology Co., Ltd.
Tel
17521259211
Email
17521259211@163.com
Country
China
ProdList
135
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
33024
Advantage
60
Nantong HI-FUTURE Biology Co., Ltd.
Tel
+undefined18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3135
Advantage
58
Nanjing Meisi Biotechnology Co., Ltd.
Tel
18118807185
Country
CHINA
ProdList
124
Advantage
58
Foshan Minghua Biotechnology Co., Ltd.
Tel
18312287787
Country
CHINA
ProdList
196
Advantage
58
Guangzhou Taozhu Biotechnology Co., Ltd
Tel
4008200310
Country
CHINA
ProdList
111
Advantage
58
Guangzhou Meijun Biotechnology Co., Ltd.
Tel
18664742264
Country
CHINA
ProdList
151
Advantage
58

133407-86-0, MG-115Related Search:

Trypsin trysin-chymotrypsin Basic protease LACTACYSTIN MG-115 MG-132 Z-LLL-AMC Z-LEU-LEU-ARG-AMC Z-LEU-LEU-4,5-DEHYDRO-LEU-ALDEHYDE Z-LEU-LEU-GLU-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN MG-262 Z-LEU-LEU-GLU-AMC Z-LEU-LEU-LEU-FMK N-CBZ-LEU-LEU-GLU BETA-NAPHTHYLAMIDE GAMMA-SECRETASE INHIBITOR 1 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) 5 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE)

  • PROTEASOME INHIBITOR MG-115
  • N-CBZ-LEU-LEU-NORVALINAL
  • MG-115
  • Z-LL-NVA-CHO
  • Z-LEU-LEU-NVA-ALDEHYDE
  • Z-LEU-LEU-NVA-CHO
  • Z-LEU-LEU-NVA-H
  • Z-LEU-LEU-NVA-H (ALDEHYDE)
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-NORVALINAL
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-NORVALINAL
  • BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-NORVALINAL
  • z-leu-leu-norvalinal
  • N-carbobenzyloxy-Leu-Leu-norvalinal
  • MG115, Z-LLnV
  • Z-Leu-Leu-Norvalinal,MG115, Z-LLnV
  • (S)-MG115
  • MG-115 (DMSO solution)
  • Z-LLnV
  • MG-115 - CAS 133407-86-0 - Calbiochem
  • L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]-
  • Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxopentan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
  • MG-115, proteasome inhibitor
  • Benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
  • 133407-86-0
  • C25H39N3O5
  • Inhibitors
  • BioChemical
  • Biochemicals and Reagents
  • Application Index
  • Cell Signaling Enzymes
  • Proteasome, Calpain and Lysosomal Proteases
  • Proteasomes
  • Enzymes, Inhibitors, and Substrates
  • Calpain and Lysosomal Proteases
  • Proteasome Inhibitors
  • Aldehydes
  • and Substrates
  • Application Index
  • Bioactive Small Molecules
  • Biochemicals and Reagents
  • Building Blocks
  • C13-C60
  • Calpain and Proteasome Inhibitors
  • Carbonyl Compounds
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cell Signaling Enzymes
  • Chemical Synthesis
  • Endoplasmic Reticulum Stress
  • Enzymes
  • Inhibitors
  • Intracellular Protein Degradation
  • Nitric Oxide and Cell Stress
  • Organic Building Blocks
  • Proteasome
  • Proteasomes
  • Z
  • ProteasomeInhibitors