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MG-115

Product Name
MG-115
CAS No.
133407-86-0
Chemical Name
MG-115
Synonyms
MG-115;Z-LLnV;(S)-MG115;Z-LL-NVA-CHO;MG115, Z-LLnV;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;z-leu-leu-norvalinal;Z-LEU-LEU-NVA-ALDEHYDE;MG-115 (DMSO solution)
CBNumber
CB0195607
Molecular Formula
C25H39N3O5
Formula Weight
461.59
MOL File
133407-86-0.mol
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MG-115 Property

Boiling point:
678.8±55.0 °C(Predicted)
Density 
1.082±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
powder
pka
11.14±0.46(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
474780
Product name
MG-115
Purity
Potent reversible proteasome inhibitor (K
Packaging
5mg
Price
$259
Updated
2024/03/01
Sigma-Aldrich
Product number
C6706
Product name
Z-Leu-Leu-Norvalinal
Purity
≥90% (HPLC), powder
Packaging
1mg
Price
$99.3
Updated
2023/06/20
Cayman Chemical
Product number
15413
Product name
(S)-MG115
Purity
≥95%
Packaging
1mg
Price
$51
Updated
2024/03/01
Cayman Chemical
Product number
15413
Product name
(S)-MG115
Purity
≥95%
Packaging
5mg
Price
$128
Updated
2024/03/01
Cayman Chemical
Product number
15413
Product name
(S)-MG115
Purity
≥95%
Packaging
10mg
Price
$229
Updated
2024/03/01
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MG-115 Chemical Properties,Usage,Production

Description

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

Uses

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]

Uses

MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

Definition

ChEBI: N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester is a peptide.

General Description

Potent reversible proteasome inhibitor (Ki = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Biochem/physiol Actions

Product does not compete with ATP.

References

1. involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. imamura, t., haruta, t., takata, y., usui, i., iwata, m., ishihara, h., ishiki, m., ishibashi, o., ueno, e., sasaoka, t., kobayashi, m. j. biol. chem. (1998)

MG-115 Preparation Products And Raw materials

Raw materials

Preparation Products

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MG-115 Suppliers

China 65 Germany 2 Japan 2 Switzerland 2 United Kingdom 3 United States 14 USA 1 Global 89
SERVA Electrophoresis GmbH
Tel
--
Fax
--
Email
info@serva.de
Country
Germany
ProdList
1142
Advantage
80
BIOTREND Chemikalien GmbH
Tel
--
Fax
--
Email
jaeger@biotrend.com
Country
Germany
ProdList
6115
Advantage
76

133407-86-0, MG-115Related Search:

Trypsin trysin-chymotrypsin Basic protease LACTACYSTIN MG-115 MG-132 Z-LLL-AMC Z-LEU-LEU-ARG-AMC Z-LEU-LEU-4,5-DEHYDRO-LEU-ALDEHYDE Z-LEU-LEU-GLU-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN MG-262 Z-LEU-LEU-GLU-AMC Z-LEU-LEU-LEU-FMK N-CBZ-LEU-LEU-GLU BETA-NAPHTHYLAMIDE GAMMA-SECRETASE INHIBITOR 1 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) 5 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE)

  • PROTEASOME INHIBITOR MG-115
  • N-CBZ-LEU-LEU-NORVALINAL
  • MG-115
  • Z-LL-NVA-CHO
  • Z-LEU-LEU-NVA-ALDEHYDE
  • Z-LEU-LEU-NVA-CHO
  • Z-LEU-LEU-NVA-H
  • Z-LEU-LEU-NVA-H (ALDEHYDE)
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-NORVALINAL
  • CARBOBENZOXY-L-LEUCYL-L-LEUCYL-NORVALINAL
  • BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-NORVALINAL
  • z-leu-leu-norvalinal
  • N-carbobenzyloxy-Leu-Leu-norvalinal
  • MG115, Z-LLnV
  • Z-Leu-Leu-Norvalinal,MG115, Z-LLnV
  • (S)-MG115
  • MG-115 (DMSO solution)
  • Z-LLnV
  • MG-115 - CAS 133407-86-0 - Calbiochem
  • L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]-
  • Benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxopentan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
  • 133407-86-0
  • C25H39N3O5
  • Inhibitors
  • BioChemical
  • Biochemicals and Reagents
  • Application Index
  • Cell Signaling Enzymes
  • Proteasome, Calpain and Lysosomal Proteases
  • Proteasomes
  • Enzymes, Inhibitors, and Substrates
  • Calpain and Lysosomal Proteases
  • Proteasome Inhibitors
  • Aldehydes
  • and Substrates
  • Application Index
  • Bioactive Small Molecules
  • Biochemicals and Reagents
  • Building Blocks
  • C13-C60
  • Calpain and Proteasome Inhibitors
  • Carbonyl Compounds
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cell Signaling Enzymes
  • Chemical Synthesis
  • Endoplasmic Reticulum Stress
  • Enzymes
  • Inhibitors
  • Intracellular Protein Degradation
  • Nitric Oxide and Cell Stress
  • Organic Building Blocks
  • Proteasome
  • Proteasomes
  • Z
  • ProteasomeInhibitors
  • peptides