Description application Reference
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MOPS

Description application Reference
Product Name
MOPS
CAS No.
1132-61-2
Chemical Name
MOPS
Synonyms
MOPS;3-(N-MORPHOLINO)PROPANESULFONIC ACID;MOPS FREE ACID;MORPHOLINOPROPANE SULFONIC ACID;3-Morpholinopropanesulfoinc Acid;4-morpholinopropanesulphonic acid;3-Morpholinopropane-1-sulfonic acid;WAS 15;MOPS,≥98%;MOPS1132-61-2
CBNumber
CB0221586
Molecular Formula
C7H15NO4S
Formula Weight
209.26
MOL File
1132-61-2.mol
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MOPS Property

Melting point:
277-282 °C
Density 
1.3168 (rough estimate)
bulk density
350kg/m3
vapor pressure 
0Pa at 25℃
refractive index 
1.6370 (estimate)
Flash point:
116 °C
storage temp. 
room temp
solubility 
H2O: 1 M at 20 °C, clear
form 
Powder/Solid
color 
White
PH
2.5-4.0 (25℃, 1M in H2O)
pka
7.2(at 25℃)
PH Range
6.5 - 7.9
Odor
Odorless
biological source
synthetic
Water Solubility 
1000 g/L (20 ºC)
λmax
λ: 260 nm Amax: 0.020
λ: 280 nm Amax: 0.015
Merck 
14,6265
BRN 
1106776
Stability:
Stable. Incompatible with strong bases, strong oxidizing agents.
InChIKey
DVLFYONBTKHTER-UHFFFAOYSA-N
LogP
-2.94 at 20℃
CAS DataBase Reference
1132-61-2(CAS DataBase Reference)
EPA Substance Registry System
4-Morpholinepropanesulfonic acid (1132-61-2)
Absorption
≤0.05 at 260nm
≤0.05 at 280nm
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
RTECS 
QE9104530
TSCA 
Yes
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHG0007
Product name
MOPS
Packaging
1KIT
Price
$1191
Updated
2024/03/01
Sigma-Aldrich
Product number
M3183
Product name
MOPS
Purity
BioPerformance Certified, suitable for cell culture, ≥99.5% (titration)
Packaging
25KG
Price
$9130
Updated
2024/03/01
Sigma-Aldrich
Product number
M1254
Product name
MOPS
Purity
≥99.5% (titration)
Packaging
25KG
Price
$7580
Updated
2024/03/01
Sigma-Aldrich
Product number
69947
Product name
MOPS
Purity
BioUltra, for molecular biology, ≥99.5% (T)
Packaging
25g
Price
$133
Updated
2024/03/01
Sigma-Aldrich
Product number
69947
Product name
MOPS
Purity
BioUltra, for molecular biology, ≥99.5% (T)
Packaging
100g
Price
$414
Updated
2024/03/01
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MOPS Chemical Properties,Usage,Production

Description

MOPS (3-morpholinopropanesulfonic acid) is a buffer introduced by Good et al. in the 1960s. It is a structural analog to MES. Its chemical structure contains a morpholine ring. HEPES is a similar pH buffering compound that contains a piperazine ring. With a pKa of 7.20, MOPS is an excellent buffer for many biological systems at near-neutral pH.It is used as a synthetic buffering agent below pH 7.5.

application

MOPS is frequently used as a buffering agent in biology and biochemistry. It has been tested and recommended for polyacrylamide gel electrophoresis. Usage above 20 mM in mammalian cell culture work is not recommended. MOPS buffer solutions become discolored (yellow) over time, but reportedly slight discoloration does not significantly affect the buffering characteristics.

Reference

P. H. Quail, D. Marme, E. Schäfer, Particle-bound phytochrome from maize and pumpkin, Nature New Biology, 1973, vol. 245, pp. 189-191

Chemical Properties

White/clear crystalline powder

Uses

MOPS acts as a multi-purpose buffering agent used in various biological research.

Uses

Due to its inert nature, 3-morpholinopropanesulfonic acid (MOPS) is widely used as a buffer in many biochemical studies. MOPS has been used as a cell culture additive component in lentiviral particle production,  a buffering agent in microbial growth medium and nuclei extraction buffer, a component of Roswell Park Memorial Institute (RPMI) medium for diluting fungal inoculum, and a buffer in capillary-zone electrophoresis to test performance. It is also used for the dilution of proteins from algal samples.

Definition

ChEBI: 3-(N-morpholino)propanesulfonic acid is a Good's buffer substance, pKa = 7.2 at 20 ℃. It is a member of morpholines, a MOPS and an organosulfonic acid. It is a conjugate acid of a 3-(N-morpholino)propanesulfonate. It is a tautomer of a 3-(N-morpholiniumyl)propanesulfonate.

General Description

3-(N-Morpholino)propane sulfonic acid (MOPS) is an N-substituted amino sulfonic acid with a morpholinic ring. MOPS is capable of buffering within a pH range of 6.5-7.9. MOPS is widely used in biological and biochemical studies due to its inert properties. It does not interact with any metal ions in solutions and has significant metal-buffer stability especially with copper (Cu), nickel (Ni), manganese (Mn), zinc (Zn), cobalt (Co) ions. MOPS buffer maintains the pH of the mammalian cell culture medium. MOPS functions to maintain pH in denaturing gel electrophoresis of RNA. MOPS can modify lipid interactions and influence the thickness and barrier properties of membranes. MOPS interacts with bovine serum albumin and stabilizes the protein. Hydrogen peroxide oxidizes MOPS slowly to N-oxide form.

Flammability and Explosibility

Not classified

Synthesis

Morpholine and 1,3-Propanesultone are added to absolute ethanol for reaction. The crude product synthesized is purified to obtain 3-Morpholinopropanesulfonic acid.

MOPS Preparation Products And Raw materials

Raw materials

Preparation Products

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MOPS Suppliers

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View Lastest Price from MOPS manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
3-Morpholinopropanesulfonic Acid 1132-61-2
Price
US $79.00-38.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-12-13
Hebei Mujin Biotechnology Co.,Ltd
Product
MOPS 1132-61-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-28
Shandong Deshang Chemical Co., Ltd.
Product
MOPS 1132-61-2
Price
US $9.90-7.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-06-28

1132-61-2, MOPSRelated Search:

1,3-Propane sultone Dimethomorph Citric acid Folic acid p-Toluenesulfonic acid Morpholine Moroxydine hydrochloride Moroxydine Taurine Ethyl 2-(Chlorosulfonyl)acetate 1-DODECANESULFONIC ACID SODIUM SALT Tridemorph Ascoric Acid MORPHINE 3-MORPHOLINOPROPANESULFONIC ACID SODIUM SALT 3-MORPHOLINOPROPANESULFONIC ACID HEMISODIUM SALT,3-N-MORPHOLINOPROPANESULFONIC ACID HEMISODIUM SALT MOPSO sodium salt MOPS BUFFER

  • MOPS
  • MOPS, CONCENTRATE SOLUTION
  • MORPHOLINOPROPANE SULFONIC ACID
  • TIMTEC-BB SBB009133
  • 4-MORPHOLINEPROPANESULFONIC ACID
  • 4-(MORPHOLINOPROPANE SULFONIC ACID)
  • 3-MORPHOLINOPROPANESULFONIC ACID
  • 3-MORPHOLINOPROPANESULPHONIC ACID
  • 3-(N-MORPHOLINO)PROPANESULFONIC ACID
  • 3-(N-MORPHOLINO)PROPANESULPHONIC ACID
  • LABOTEST-BB LT00455082
  • LABOTEST-BB LT01595956
  • MOPS,BIOLOGICALBUFFER
  • 4-Morpholinopropansulfonsure
  • 4-MORPHOLINEPROPANESULFONIC ACID MOPS
  • MOPS ULTRAPURE
  • MOPS (3-MORPHOLINOPROPANESULFONIC ACID)
  • MOPS (3-MORPHOLINOPROPANESULFONIC ACID), HIGH PURITY
  • 3-MORPHOLINOPROPANESULPHONIC ACID extrapure
  • 3-(N-Morpholino)propanesulfonic acid, 4-Morpholinepropanesulfonic acid
  • WAS 15
  • 3-Morpholinopropanesulfonic acid ,99.5%
  • MOPS, 99%, FOR BIOCHEMISTRY
  • MOPS, 99.5%, DNASE, RNASE, PROT. FREE, FOR PEPTIDE SEQUENCING, FOR MOLECULAR BIOLOGY
  • MOPS, Dnase, Rnase, Prot. free, for peptide sequencing, for molecular biology
  • 3-(4-Morpholinyl)-1-propanesulfonic acid
  • 3-Morpholino-1-propanesulfonic acid
  • 3-Morpholinopropane-1-sulfonic acid
  • 4-Morpholinepropane-1-sulfonic acid
  • MOPS,99.5%,for molecular biology,Dnase, Rnase, Prot. free, for peptide sequencing
  • 3-(N-MORPHOLINO) PROPANESULPHONIC ACID, ULTRAPURE >99.5
  • 3-(N-Morpholino)propanesulphonic acid, low sodium >99.5%
  • MOPS low sodium
  • 3-Morpholinopropanesulfonic Acid [Good's buffer component for biological research]
  • Morpholinepropanesulfonic acid, 4-
  • MOPS1132-61-2
  • MOPS,3-(N-Morpholino)propanesulfonic acid, 4-Morpholinepropanesulfonic acid
  • 3-Morpholinopropanes
  • 3-(Morpholin-4-yl)propanesulphonic acid, ultrapure >99.5%
  • 3-N-Morpholinopropanesulfonic acidMolecular biology grade, ≥ 99.5% (Titration)
  • MOPS, Free Acid, Molecular Biology Grade
  • MOPS, Free Acid, ULTROL
  • MOPS, Cell culture tested
  • MOPS, DNAse, RNAse and Protease Free
  • MOPS, BIOPERFORMANCE CERTIFIED, CELL
  • MOPS, Free Acid, ULTROL Grade - CAS 1132-61-2 - Calbiochem
  • OmniPur MOPS - CAS 1132-61-2 - Calbiochem
  • 3-(N-MORPHOLINO)PROPANESULFONIC ACID3-(N-MORPHOLINO)PROPANESULFONIC ACID3-(N-MORPHOLINO)PROPANESULFONIC ACID3-(N-MORPHOLINO)PROPANESULFONIC ACID
  • MOPS, ≥99.5% (T)
  • MOPS, ≥99.0%(T)
  • 3-Morpholinopropanesulfonic acid 1132-61-2 4-Morpholinepropanesulfonic acid
  • 1132-61-2 4-Morpholinepropanesulfonic acid MOPS
  • MOPS FREE ACID, BIOTECHNOLOGY PERFORMANC E CERTIFIED
  • 3-Morpholinopropanesulfonic ac
  • 3-N-morpholinopropansulfonic acid
  • MOPS 3-(N-Morpholino)propanesulfonic acid
  • MOPS, 10X Liquid Concentrate,Molecular Biology Grade
  • MOPS, Free Acid, MB Grade (1.01545)