ChemicalBook > CAS DataBase List > UTP

UTP

Product Name
UTP
CAS No.
63-39-8
Chemical Name
UTP
Synonyms
UTP-NA;UTP TRISODIUM SALT;pppU;5’-utp;uteplex;UTP, 3NA;Uracylic;UTP, NA3H;Urd-5'-P3;UTP Sodium
CBNumber
CB0221667
Molecular Formula
C9H15N2O15P3
Formula Weight
484.14
MOL File
63-39-8.mol
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UTP Property

Density 
2.106±0.06 g/cm3(Predicted)
Flash point:
113 °C
storage temp. 
Sealed in dry,2-8°C
solubility 
Easily soluble (water)
pka
pK1:7.58 (25°C)
form 
liquid
color 
colorless
Water Solubility 
Water : ≥ 150 mg/mL (309.83 mM)
CAS DataBase Reference
63-39-8(CAS DataBase Reference)
EPA Substance Registry System
Uridine 5'-(tetrahydrogen triphosphate) (63-39-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-68/20/21/22
Safety Statements 
22-26-36
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
U1006
Product name
Uridine 5′-triphosphate trisodium salt solution
Purity
HPLC purified, aqueous solution for RNA polymerase transcription
Packaging
25μmol
Price
$123
Updated
2024/03/01
Usbiological
Product number
366675
Product name
Uridine Triphosphate
Packaging
96Tests
Price
$954
Updated
2021/12/16
ChemScene
Product number
CS-7777
Product name
Uridinetriphosphate
Purity
≥98.0%
Packaging
10mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
NU03863
Product name
Uridine 5'-triphosphate trisodium salt
Packaging
5G
Price
$65
Updated
2021/12/16
ChemScene
Product number
CS-7777
Product name
Uridinetriphosphate
Purity
≥98.0%
Packaging
50mg
Price
$80
Updated
2021/12/16
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UTP Chemical Properties,Usage,Production

Description

Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

Occurrence

Uridine 5'-triphosphate is a natural product found in Helianthus tuberosus, Apis cerana, and other organisms with data available.

Uses

Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).

Definition

UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a pyrimidine ribonucleoside 5'-triphosphate and a uridine 5'-phosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).

Biochem/physiol Actions

P2Y receptor agonist

Pharmacokinetics

INS316 is a short-acting, aerosolized uridine 5-triphosphate (UTP) solution used as a diagnostic aid for lung cancer. INS316 appears to improve sputum expectoration mediated through the P2Y2 receptor, a nucleotide receptor expressed in human airway epithelial cells and some other tissues. UTP binding to the P2Y2 receptor triggers signal transduction that leads to chloride ion secretion, thereby resulting in mucociliary clearance of airway.

in vitro

Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K.

in vivo

Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes.

References

[1]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.
[2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.
[3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.
[4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5'-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.

UTP Preparation Products And Raw materials

Raw materials

Preparation Products

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UTP Suppliers

China 90 Germany 3 India 4 Japan 2 Switzerland 1 United Kingdom 5 United States 35 Global 140
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View Lastest Price from UTP manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
UTP 63-39-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
UTP 63-39-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg
Release date
2019-08-29

63-39-8, UTPRelated Search:

Uridine-5'-triphosphoric acid trisodium salt Uridine UDP-ALPHA-D-GALACTOSE DISODIUM SALT Uridine 5'-(trihydrogen diphosphate) P'-(6-azido-6-deoxy-alpha-D-glucopyranosyl) ester UTP TRIS SALT cytidine 3',5'-diphosphate Diquafosol Impurity 12 Diquafosol INS 365 DUTP, 100MM SOLUTION uridine 5'-tetraphosphate Diquafosol Impurity 10 UMP UDPGA TRISODIUM SALT URIDINE-13C9, 15N2-5 TRIPHOSPHATE SODI U UDP Uridine-5'-diphosphate disodium salt Uridine 5′-monophosphate disodium salt

  • 5'-URIDYLATE TRIPHOSPHATE
  • UTP, 3NA
  • UTP-NA
  • UTP, NA3H
  • UTP SODIUM SALT
  • UTP TRISODIUM SALT
  • URIDINE 5'-TRIPHOSPHATE
  • URIDINE-5'-TRIPHOSPHATE NA3-SALT
  • URIDINE-5'-TRIPHOSPHATE SODIUM
  • URIDINE 5'-TRIPHOSPHATE SODIUM SALT
  • URIDINE 5-TRIPHOSPHATE TRISODIUM
  • URIDINE-5'-TRIPHOSPHATE TRISODIUM SALT
  • URIDINE-5'-TRIPHOSPHORIC ACID, TRISODIUM
  • 5’-utp
  • uridine,5’-(tetrahydrogentriphosphate)
  • uridine5’-triphosphoricacid
  • uridinetriphosphate
  • uteplex
  • ({[(2S,3R,4S,5S)-5-(2,4-dioxo-1,2,3,4-tetrahydropyriMidin-1-yl)-3,4-dihydroxyoxolan-2-yl]Methyl phosphonato}oxy)(phosphonatooxy)phosphinate
  • Uridine 5′-triphosphate trisodium salt solution
  • Uracylic
  • [[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid
  • 5'-uridylate triphosphate (UTP)
  • Uridine-5''-triphosphoric acid (and/or unspecified salts)
  • Uridine 5μ-triphosphate solution trisodium salt
  • pppU
  • Urd-5'-P3
  • UTP .Free Acid
  • Mix of 25 mM ATP, CTP, GTP and UTP Adenosine-5'-triphosphate, Sodium salt
  • Uridine-5'-triphosphate Free acid
  • UTP Solution (100mM)
  • ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
  • triphosphoric acid 1-uridin-5'-yl ester
  • UTP Sodium
  • UTP 200mM Tris Solution, GMP grade
  • UTP 200mM Tris Solution
  • UTP Sodium Solution,UltraNUcTM?NTPs
  • Uridine 5'-(tetrahydrogen triphosphate)
  • Uridine 5'-triphosphate
  • 63-39-8
  • C9H15N2O15P3
  • Nucleotides
  • DNA / RNA Synthesis
  • NTP
  • Elisa Kit-plant ELISA Kit