Phenoxyacetyl chloride

Product Name: Phenoxyacetyl chloride
CAS No.: 701-99-5
Chemical Name: Phenoxyacetyl chloride
Synonyms: SKL1266;AKOS BBS-00003927;Acyl chloride kind;Phenoxyacetyl chlori;phenoxy-acetylchlorid;PHENOXYACETYL CHLORIDE;LABOTEST-BB LT00643586;Acetylchloride,phenoxy-;Phenyloxyacetyl chloride;PhenoxyacetylChloride>
CBNumber: CB0227245
Molecular Formula: C8H7ClO2
Formula Weight: 170.59
MOL File: 701-99-5.mol

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Phenoxyacetyl chloride Property

Melting point:: 100-100.5 °C
Boiling point:: 225-226 °C (lit.)
Density: 1.235 g/mL at 25 °C (lit.)
refractive index: n20/D 1.534(lit.)
Flash point:: 227 °F
storage temp.: Store at RT.
form: Liquid
color: Clear slightly yellow to brown
Water Solubility: Reacts with water.
Sensitive: Moisture Sensitive
BRN: 607585
InChI: InChI=1S/C8H7ClO2/c9-8(10)6-11-7-4-2-1-3-5-7/h1-5H,6H2
InChIKey: PKUPAJQAJXVUEK-UHFFFAOYSA-N
SMILES: C(Cl)(COC1=CC=CC=C1)=O
CAS DataBase Reference: 701-99-5(CAS DataBase Reference)
NIST Chemistry Reference: Acetyl chloride, phenoxy-(701-99-5)
EPA Substance Registry System: Acetyl chloride, phenoxy- (701-99-5)

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Safety

Hazard Codes: C
Risk Statements: 14-34-36/37
Safety Statements: 26-36/37/39-45
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
F: 10-19
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29189090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 158623
Product name: Phenoxyacetyl chloride
Purity: 98%
Packaging: 10g
Price: $50.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: 158623
Product name: Phenoxyacetyl chloride
Purity: 98%
Packaging: 50g
Price: $144.4
Updated: 2025/07/31

TCI Chemical

Product number: P0113
Product name: Phenoxyacetyl Chloride
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: P0113
Product name: Phenoxyacetyl Chloride
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $350
Updated: 2025/07/31

Sigma-Aldrich

Product number: 158623
Product name: Phenoxyacetyl chloride
Purity: 98%
Packaging: 250g
Price: $321.65
Updated: 2025/07/31

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Phenoxyacetyl chloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to brown liquid

Uses

Acylation of D- and DL-WV with phenoxyacetyl chloride, followed by cleavage of the t-butyl ester,afforded the penultimate penicilloic acids. Phenoxyacetyl chloride was used in the synthesis of series of macrocyclic bis-β-lactams, 5-phenyl-6-epiphenoxymethylpenicillin benzyl ester, N-protected guanosine derivatives, useful in RNA synthesis, phenyloxyketene, for cycloaddition to imines leading to β-lactams. Treatment of iminophosphoranes with phenoxyacetyl chloride afforded respectively the trans- and cis-3-(acylamino)-p-lactams. By the oxidative addition of stannous fluoride to allyliodide, with 1, 2-O-isopropylidene-D-glyceraldehyde and phenoxyacetyl chloride results in the predominant formation of erythro homoallylester, which is in turn converted into 2-deoxy-D-ribose. The 4-disubstituted P-lactams (4a-c and 6a-b) were prepared through the reaction of N,N-diphenylhydrazones and N-methyl-N-phenylhydrazones of ketones with phenoxyacetyl chloride/Et3N in dichloromethane.

Uses

Phenoxyacetyl chloride was used in the synthesis of:

series of macrocyclic bis-β-lactams
5-phenyl-6-epiphenoxymethylpenicillin benzyl ester
N-protected guanosine derivatives, useful in RNA synthesis
phenyloxyketene, for cycloaddition to imines leading to β-lactams

Purification Methods

If it has no OH band in the IR then distil it in a vacuum, taking precautions for the moisture-sensitive compound. If it contains free acid (due to hydrolysis, OH bands in the IR), then add an equal volume of redistilled SOCl2, reflux for 2-3hours, evaporate and distil the residue in a vacuum as before. The amide has m 101o. [McElvain & Carney J Am Chem Soc 68 2592 1946, Beilstein 6 III 613.]

Phenoxyacetyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Phenoxyacetyl chloride Suppliers

Americas 1 Belgium 1 China 103 Europe 4 France 2 Germany 5 India 5 Japan 4 Slovakia 1 Switzerland 3 United Kingdom 10 United States 24 Global 163

Aladdin Scientific

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Advanced Synthesis Technologies

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View Lastest Price from Phenoxyacetyl chloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Phenoxyacetyl chloride 701-99-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-26

Zhuozhou Wenxi import and Export Co., Ltd

Product: Phenoxyacetyl chloride 701-99-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Phenoxyacetyl Chloride 701-99-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

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C6H5OCH2COCl

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