ChemicalBook > CAS DataBase List > 7-METHYLINDOLE-3-CARBOXALDEHYDE
7-METHYLINDOLE-3-CARBOXALDEHYDE
- Product Name
- 7-METHYLINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 4771-50-0
- Chemical Name
- 7-METHYLINDOLE-3-CARBOXALDEHYDE
- Synonyms
- Antifungal agent 98;CCR1/5/8 activator 1;3-FORMYL-7-METHYLINDOLE;7-METHYLINDOLE-3-ALDEHYDE;7-Methyl-3-carboxaldehyde;7-METHYLINDOLE-3-CARBOXALDEHYDE;7-Methyl-3-indolecarboxaldehyde;7-METHYLINDOLE-3-CARBOXYALDEHYDE;7-METHYL-1H-INDOLE-3-CARBALDEHYDE;7-Methylindole-3-carboxaldehyde 98%
- CBNumber
- CB0229603
- Molecular Formula
- C10H9NO
- Formula Weight
- 159.18
- MOL File
- 4771-50-0.mol
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7-METHYLINDOLE-3-CARBOXALDEHYDE Property
- Melting point:
- 206-208°C
- Boiling point:
- 341.0±22.0 °C(Predicted)
- Density
- 1.226±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- Solid
- pka
- 15.80±0.30(Predicted)
- color
- Yellow to brown
- Sensitive
- Air Sensitive
- BRN
- 122340
- InChI
- InChI=1S/C10H9NO/c1-7-3-2-4-9-8(6-12)5-11-10(7)9/h2-6,11H,1H3
- InChIKey
- KTUFZHVVJBHGKZ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2C)C(C=O)=C1
- CAS DataBase Reference
- 4771-50-0(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TRC
- Product number
- M313628
- Product name
- 7-Methylindole-3-carboxyaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 069433
- Product name
- 3-Formyl-7-methylindole
- Purity
- 96%
- Packaging
- 500mg
- Price
- $57
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 069433
- Product name
- 3-Formyl-7-methylindole
- Purity
- 96%
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM1555378
- Product name
- 7-METHYLINDOLE-3-CARBOXALDEHYDE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $120.82
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H15-1-55
- Product name
- 7-Methylindole-3-carboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
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7-METHYLINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production
Uses
Reactant for preparation of:• ;Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators1• ;Antibacterial and antituberculosis agents2• ;Antiandrogens effective against androgen receptor mutants3• ;Anti-bovine viral diarrhea virus (BVDV) agents4• ;Receptor subtype 5 antagonists5• ;Glucocorticoid receptor ligands6• ;Necroptosis inhibitors7• ;Orally efficacious small-molecule sctivator of the insulin receptor8
Uses
Reactant for preparation of:
- Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
- Antibacterial and antituberculosis agents
- Antiandrogens effective against androgen receptor mutants
- Anti-bovine viral diarrhea virus (BVDV) agents
- Receptor subtype 5 antagonists
- Glucocorticoid receptor ligands
- Necroptosis inhibitors
- Orally efficacious small-molecule sctivator of the insulin receptor
Synthesis
933-67-5
100-97-0
4771-50-0
General procedure for the synthesis of 7-methylindole-3-carboxaldehyde from 7-methylindole and ouvertropine: To a 50 mL round-bottomed flask fitted with a magnetic stirrer were added sequentially 7-methylindole (1.0 mmol, 1.0 eq.), hexamethylenetetetramine (HMTA, 2.0 mmol, 0.2803 g, 2.0 eq.), activated carbon (0.1 g), and N,N- dimethylformamide (DMF, 2 mL). Iodine (I2, 0.2 mmol, 0.0507 g, 20 mol%) was then added and the flask was assembled with a reflux condenser tube. The reaction mixture was stirred at 120 °C and the progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature. The resulting mixture was filtered through a diatomaceous earth pad and the filter cake was washed well with ethyl acetate (EtOAc, 4 x 6 mL). The combined filtrates were washed sequentially with 0.5 M aqueous hydrochloric acid (10 mL), saturated sodium bicarbonate (NaHCO3) solution (10 mL), and saturated sodium chloride (NaCl) solution (10 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography, and the target product 7-methylindole-3-carbaldehyde was obtained by using a mixed solvent of hexane and ethyl acetate as eluent.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 30, p. 2877 - 2880
[2] Patent: CN108329249, 2018, A. Location in patent: Paragraph 0041-0044; 0066-0069
7-METHYLINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-METHYLINDOLE-3-CARBOXALDEHYDE manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 7-Methyl-1H-indole-3-carbaldehyde 4771-50-0
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
Shaanxi Dideu Medichem Co. Ltd
- Product
- 7-Methylindole-3-carboxaldehyde 4771-50-0
- Price
- US $1.00-1.50/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2024-07-17
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 7-METHYLINDOLE-3-CARBOXALDEHYDE 4771-50-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
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