7-Fluoro-4-chromanone

Product Name: 7-Fluoro-4-chromanone
CAS No.: 113209-68-0
Chemical Name: 7-Fluoro-4-chromanone
Synonyms: 7-FLUOROCHROMAN-4-ONE;7-Fluoro-4-chromanone;7-fluoro-2,3-dihydrochromen-4-one;7-Fluoro-2,3-dihydro-4H-chromen-4-one;7-Fluorochroman-4-one, sum of isomers;7-Fluoro-2,3-dihydro-4H-chromen-4-one 97%;6-fluoro-3,4-dihydro-2H-1-benzopyran-4-one;4H-1-BENZOPYRAN-4-ONE, 7-FLUORO-2,3-DIHYDRO-;7-Fluorochroman-4-one, may contain up to 15% 5-isomer;7-FluorochroMan-4-one, May contain up to 15% 5-isoMer(suM of isoMers
CBNumber: CB0229719
Molecular Formula: C9H7FO2
Formula Weight: 166.15
MOL File: 113209-68-0.mol

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7-Fluoro-4-chromanone Property

Melting point:: 46-50℃
Boiling point:: 281.9±40.0 °C(Predicted)
Density: 1.297±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: Pale purple to purple Solid
InChI: InChI=1S/C9H7FO2/c10-6-1-2-7-8(11)3-4-12-9(7)5-6/h1-2,5H,3-4H2
InChIKey: HRPULQFHSZKTNA-UHFFFAOYSA-N
SMILES: C1OC2=CC(F)=CC=C2C(=O)C1
CAS DataBase Reference: 113209-68-0

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: F588413
Product name: 7-Fluorochroman-4-one
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: F588413
Product name: 7-Fluorochroman-4-one
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 076457
Product name: 7-Fluorochroman-4-one
Purity: 95+%
Packaging: 1g
Price: $93
Updated: 2021/12/16

Apolloscientific

Product number: PC200546
Product name: 7-Fluoro-2,3-dihydro-4H-chromen-4-one
Purity: 97%
Packaging: 5g
Price: $167
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H17-3-0C
Product name: 7-Fluoro-2,3-dihydro-4H-chromen-4-one
Purity: 97%
Packaging: 5G
Price: $268
Updated: 2021/12/16

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7-Fluoro-4-chromanone Chemical Properties,Usage,Production

Synthesis

133077-42-6

113209-68-0

The general procedure for the synthesis of 7-fluorobenzodihydropyran-4-one from 3-(3-fluorophenoxy)propionic acid is as follows: C. Synthesis of 7-fluorobenzodihydropyran-4-one. 3-(3-Fluorophenoxy)propionic acid (2.2 g, 0.011 mol) was dissolved in toluene (25 mL) and thionyl chloride (4.0 mL, 0.054 mol) was added. The reaction mixture was heated to reflux for 1.5 hours and subsequently concentrated under vacuum. The residue was dissolved in chloroform (25 mL), cooled to -65°C and trifluoromethanesulfonic acid (1.5 mL, 0.017 mol) was added dropwise. The mixture was slowly warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, water was added for stratification and the organic layer was washed with 1N NaOH solution. The organic extracts were combined, dried with anhydrous magnesium sulfate, filtered and concentrated, and finally purified by fast column chromatography (eluent: hexane/ethyl acetate) to afford 7-fluorobenzodihydropyran-4-one (0.96 g, 53% yield). Product Characterization: HPLC (reversed phase): retention time RT = 8.22 min. 1H NMR (500 MHz, CDCl3): δ 7.92 (dd, J = 8.8, 6.7 Hz, 1H), 6.75-6.72 (m, 1H), 6.66 (dd, J = 9.9, 2.4 Hz, 1H), 4.55 (t, J = 6.4 Hz, 2H), 2.80 (t, J = 6.5 Hz, 2H).

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2468 - 2477
[2] Patent: US2005/38032, 2005, A1. Location in patent: Page/Page column 30
[3] Patent: WO2006/66746, 2006, A1. Location in patent: Page/Page column 30
[4] Patent: WO2006/66756, 2006, A1. Location in patent: Page/Page column 24-25
[5] Patent: WO2005/92854, 2005, A1. Location in patent: Page/Page column 56

7-Fluoro-4-chromanone Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Fluoro-4-chromanone Suppliers

China 102 Germany 1 India 3 South Korea 1 United Kingdom 1 United States 12 Global 120

Service Chemical Inc.

Tel: --
Fax: --
Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
Advantage: 71

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View Lastest Price from 7-Fluoro-4-chromanone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 7-fluoro-4-chromanone 113209-68-0
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

Career Henan Chemical Co

Product: 7-Fluoro-4-chromanone 113209-68-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-25

113209-68-0, 7-Fluoro-4-chromanoneRelated Search:

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6-fluoro-3,4-dihydro-2H-1-benzopyran-4-one

7-FluorochroMan-4-one, May contain up to 15% 5-isoMer, 98% (suM of isoMers)

7-FLUOROCHROMAN-4-ONE

4H-1-BENZOPYRAN-4-ONE, 7-FLUORO-2,3-DIHYDRO-

7-Fluoro-4-chromanone

7-Fluorochroman-4-one, sum of isomers

7-FluorochroMan-4-one, May contain up to 15% 5-isoMer, 98% (suM of i

7-FluorochroMan-4-one, May contain up to 15% 5-isoMer(suM of isoMers

7-Fluoro-2,3-dihydro-4H-chromen-4-one

7-Fluorochroman-4-one, may contain up to 15% 5-isomer

7-Fluoro-2,3-dihydro-4H-chromen-4-one 97%

7-fluoro-2,3-dihydrochromen-4-one

113209-68-0