ChemicalBook > CAS DataBase List > 5-Bromoindole-2-carboxylic acid

5-Bromoindole-2-carboxylic acid

Product Name: 5-Bromoindole-2-carboxylic acid
CAS No.: 7254-19-5
Chemical Name: 5-Bromoindole-2-carboxylic acid
Synonyms: 5-BROMO-1H-INDOLE-2-CARBOXYLIC ACID;NSC 73384;AKOS JY2082545;Orforglipron impurity 35;5-Bromo-2-carboxy-1H-indole;5-BROMOINDOLE-2-CARBOXYLIC ACID;5-BROMO-2-INDOLECARBOXYLIC ACID;5-Bromoindazole-2-carboxylic acid;5-Bromoindole-2-carboxylicAcid>5-BroMo-1H-indol-2-carboxylic acid
CBNumber: CB0242185
Molecular Formula: C9H6BrNO2
Formula Weight: 240.05
MOL File: 7254-19-5.mol

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5-Bromoindole-2-carboxylic acid Property

Melting point:: 287-288
Boiling point:: 470.9±25.0 °C(Predicted)
Density: 1.838±0.06 g/cm3(Predicted)
storage temp.: -20°C
pka: 4.25±0.30(Predicted)
form: Solid
color: White to Light yellow to Light orange
InChI: InChI=1S/C9H6BrNO2/c10-6-1-2-7-5(3-6)4-8(11-7)9(12)13/h1-4,11H,(H,12,13)
InChIKey: YAULOOYNCJDPPU-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(Br)C=C2)C=C1C(O)=O
CAS DataBase Reference: 7254-19-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B2761
Product name: 5-Bromoindole-2-carboxylic acid
Purity: 98%
Packaging: 1g
Price: $136
Updated: 2025/07/31

TCI Chemical

Product number: B3836
Product name: 5-Bromoindole-2-carboxylic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $101
Updated: 2025/07/31

TRC

Product number: B688993
Product name: 5-Bromoindole-2-carboxylic Acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 038225
Product name: 5-Bromo-1H-indole-2-carboxylic acid
Packaging: 1g
Price: $19
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-9-Y6
Product name: 5-Bromo-1H-indole-2-carboxylic acid
Packaging: 1g
Price: $28
Updated: 2021/12/16

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5-Bromoindole-2-carboxylic acid Chemical Properties,Usage,Production

Uses

Reactant involved in studies of biologically active molecules including:

Discovery of indole inhibitors of MMP-13 for treatment of arthritic diseases
Synthesis of indolyl ethanones as indoleamine 2,3-dioxygenase inhibitors
cis-Diaminocyclohexane derivatives prepared for use as factor Xa inhibitors
Synthesis of tubulin polymerization inhibitors and cancer cell growth inhibitors
Preparation of dual PPARγ/δ agonists
Synthesis of chemical probes to examine the role of hFPRL1 receptor in inflammation

Uses

5-Bromoindole-2-carboxylic acid,Reactant involved in studies of biologically active molecules including:Discovery of indole inhibitors of MMP-13 for treatment of arthritic diseases1;Synthesis of indolyl ethanones as indoleamine 2,3-dioxygenase inhibitors2 ;cis-Diaminocyclohexane derivatives prepared for use as factor Xa inhibitors3 ;Synthesis of tubulin polymerization inhibitors and cancer cell growth inhibitors4 ;Preparation of dual PPARγ/δ agonists5;Synthesis of chemical probes to examine the role of hFPRL1 receptor .

Synthesis

16732-70-0

7254-19-5

The general procedure for the synthesis of 5-bromoindole-2-carboxylic acid from ethyl 5-bromoindole-2-carboxylate was as follows: 134 g of ethyl 5-bromoindole-2-carboxylate was dissolved in a solvent mixture of 31.25 g of 96% methanol and 183 mL of water, and was heated and refluxed for 0.5 h. The reaction was completed with the addition of 10% hydrochloric acid. After completion of the reaction, it was cooled to 40 °C and the pH was adjusted to 3-4 by slowly adding 10% hydrochloric acid solution.Subsequently, the reaction mixture was filtered to give 109.1 g of off-white solid 5-bromoindole-2-carboxylic acid in 91% yield, which was analyzed by high-performance liquid chromatography (HPLC) and showed ≥96% purity.

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 23, p. 7512 - 7527
[2] Advanced Synthesis and Catalysis, 2016, vol. 358, # 24, p. 3938 - 3942
[3] Patent: CN104402795, 2017, B. Location in patent: Paragraph 0050; 0053

5-Bromoindole-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Ethanol Ethyl pyruvate Lithium hydroxide 4-BROMOPHENYLHYDRAZINE HYDROCHLORIDE Polyphosphoric acid

Preparation Products

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View Lastest Price from 5-Bromoindole-2-carboxylic acid manufacturers

Jinan Jianfeng Chemical Co., Ltd

Product: 5-Bromoindole-2-carboxylic acid 7254-19-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-07

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Bromoindole-2-carboxylic acid 7254-19-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromoindole-2-carboxylic acid 7254-19-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-20

7254-19-5, 5-Bromoindole-2-carboxylic acidRelated Search:

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5-BROMO-1H-INDOLE-2-CARBOXYLIC ACID

5-BROMO-2-INDOLECARBOXYLIC ACID

5-BROMOINDOLE-2-CARBOXYLIC ACID

AKOS JY2082545

1H-INDOLE-2-CARBOXYLIC ACID, 5-BROMO-

5-bromoindole-2-carboxylicacid5-Bromoindole-2-carboxylicacid

5-Bromoindole-2-carboxylic acid ,98%

5-BroMo-1H-indol-2-carboxylic acid

NSC 73384

5-Bromoindazole-2-carboxylic acid

5-Bromo-2-carboxy-1H-indole

5-Bromoindole-2-carboxylicAcid&gt

Orforglipron impurity 35

7254-19-5

Br1C9H6N1O2

C9H6BrNO2

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Indoles

Heterocycles series

Indole/indoline/oxindole

Indole and Indoline

Indoles and derivatives

pharmacetical

Organic acids

Indoles

Indole

Halogenated Heterocycles

Heterocyclic Building Blocks

IndolesBuilding Blocks

Pharmaceutical Intermediates

Building Blocks

C7 to C10

C7 to C9

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks