ChemicalBook > CAS DataBase List > 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine

3-Bromo-[1,2,4]triazolo[4,3-a]pyridine

Product Name
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
CAS No.
4922-68-3
Chemical Name
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
Synonyms
Ponatinib Impurity 9;s-Triazolo[4,3-a]pyridine, 3-bromo-;3-bromo-[1,2,4]triazolo[4,3-a]pyridine;1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO-
CBNumber
CB02456245
Molecular Formula
C6H4BrN3
Formula Weight
198.02
MOL File
4922-68-3.mol
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3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Property

Melting point:
165-167 °C
Density 
1.89±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.97±0.50(Predicted)
Appearance
Light brown to brown Solid
InChI
InChI=1S/C6H4BrN3/c7-6-9-8-5-3-1-2-4-10(5)6/h1-4H
InChIKey
BOKHADJFZUWNSH-UHFFFAOYSA-N
SMILES
C12=NN=C(Br)N1C=CC=C2
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H310Fatal in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B688425
Product name
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
Packaging
100mg
Price
$130
Updated
2021/12/16
TRC
Product number
B688425
Product name
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
Packaging
1g
Price
$935
Updated
2021/12/16
Matrix Scientific
Product number
074636
Product name
3-Bromo[1,2,4]triazolo[4,3-a]pyridine
Purity
95+%
Packaging
1g
Price
$899
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0143576
Product name
3-BROMO[1,2,4]TRIAZOLO[4,3-ALPHA]PYRIDINE
Purity
95.00%
Packaging
250MG
Price
$1034.88
Updated
2021/12/16
AK Scientific
Product number
W6495
Product name
3-Bromo[1,2,4]triazolo[4,3-a]pyridine
Packaging
25g
Price
$1400
Updated
2021/12/16
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3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Chemical Properties,Usage,Production

Uses

3-Bromo-[1,2,4]triazolo[4,3-a]pyridine is an intermediate used to prepare bi-aryl amines as mGluR5 modulators for treating gastrointestinal, urinary tract, and nervous system disorders.

Synthesis

274-80-6

4922-68-3

General procedure for the synthesis of 3-bromo-[1,2,4]triazolo[4,3-a]pyridine from [1,2,4]triazolo[4,3-a]pyridine: [1,2,4]triazolo[4,3-a]pyridine (1.26 g) and N-bromosuccinimide (NBS, 1.98 g) were dissolved in chloroform, and the reaction was carried out at reflux for 5 h followed by a 14-h stand at room temperature. Upon completion of the reaction, saturated aqueous potassium carbonate (200 mL) and potassium hydroxide (20 g) were added to the mixture, and the organic layer was separated after sufficient shaking. The aqueous layer was extracted twice with dichloromethane (DCM). All organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) followed by evaporation of the solvent under vacuum to afford the target product 3-bromo-[1,2,4]triazolo[4,3-a]pyridine in 60% yield.

References

[1] Patent: EP2743266, 2014, A2. Location in patent: Page/Page column

3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-Bromo-[1,2,4]triazolo[4,3-a]pyridine 4922-68-3
Price
US $1.00-2.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2024-08-09
Career Henan Chemical Co
Product
1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO- 4922-68-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-03

4922-68-3, 3-Bromo-[1,2,4]triazolo[4,3-a]pyridineRelated Search:

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