3-BROMOIMIDAZO[1,2-B]PYRIDAZINE

Product Name: 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
CAS No.: 18087-73-5
Chemical Name: 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
Synonyms: Ponatinib Impurity 2;Ponatinib intermediate;3-BroMoiMidazo[1,2-b]pyri...;3-broMoiMidazo(1,2-b)pyridazin;3-BROMOIMIDAZO[1,2-B]PYRIDAZINE;IMidazo[1,2-b]pyridazine, 3-broMo-;3-Bromoimidazo[1,2-b]pyridazine >3-Bromoimidazo[1,2-b]pyridazine;3-Bromo-4-Hydroimidazo[1,2-e]Pyridazine;3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 18087-73-5
CBNumber: CB11515636
Molecular Formula: C6H4BrN3
Formula Weight: 198.02
MOL File: 18087-73-5.mol

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3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Property

Melting point:: 148.0 to 152.0 °C
Density: 1.89
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
pka: 2.35±0.30(Predicted)
color: White to Light yellow
InChI: InChI=1S/C6H4BrN3/c7-5-4-8-6-2-1-3-9-10(5)6/h1-4H
InChIKey: KJQVHOFAWISYDO-UHFFFAOYSA-N
SMILES: C12=NC=C(Br)N1N=CC=C2
CAS DataBase Reference: 18087-73-5

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 24/25
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4652
Product name: 3-Bromoimidazo[1,2-b]pyridazine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $34
Updated: 2025/07/31

TRC

Product number: B696300
Product name: 3-Bromoimidazo[1,2-b]pyridazine
Packaging: 5g
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: J99669
Product name: 3-Bromoimidazo[1,2-b]pyridazine
Packaging: 10g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB33555
Product name: 3-Bromoimidazo[1,2-b]pyridazine
Packaging: 10g
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-51
Product name: 3-Bromoimidazo[1,2-b]pyridazine
Purity: 95%
Packaging: 5G
Price: $136
Updated: 2021/12/16

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3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Chemical Properties,Usage,Production

Uses

3-Bromoimidazo[1,2-B]pyridazine is a pharmaceutical intermediate compound. It is used in the preparation of Ponatinib, a tyrosine kinase inhibitor (TKI), which is used in the treatment of chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL).

Synthesis

766-55-2

18087-73-5

Imidazo[1,2-b]pyridazine (6.0 g, 50.4 mmol) was used as starting material, and N-bromosuccinimide (NBS, 6.0 g, 75.6 mmol) and a catalytic amount of azobisisobutyronitrile (AIBN) were added in 50 mL of chloroform. The reaction mixture was heated and refluxed for 2 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and subsequently stirred under ice bath conditions to promote precipitation. The precipitate was separated by filtration and the filtrate was concentrated to afford the target product 3-bromoimidazo[1,2-b]pyridazine as a pale yellow solid in 75% yield.

References

[1] Patent: CN105418615, 2016, A. Location in patent: Paragraph 0079 ; 0080 ; 0081; 0082; 0083; 0084
[2] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 23, p. 5830 - 5835
[3] Patent: EP2818471, 2014, A1. Location in patent: Paragraph 0122; 0123
[4] Synthesis, 1981, # 12, p. 987 - 989
[5] Patent: WO2016/210036, 2016, A1. Location in patent: Page/Page column 107

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Suppliers

Americas 1 China 238 China Hong Kong 1 Europe 1 Germany 2 Hungary 1 India 9 Japan 2 The Netherlands 1 United Kingdom 6 United States 29 Global 291

Shanghai Sainty Biotechnology Co., Ltd.

Tel: 021-58957915 17721108391
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Nanjing YiFan Biological Technology Co., Ltd.

Tel: 025-025-52700520 18914499889
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Email: sales@yfbiotech.com
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Zhengzhou Acme Chemical Co., Ltd.

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Zhengzhou Ailfield Chemical Co., Ltd.

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Haohong (Qihe) Medical Technology Co., LTD

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SiChuang NanBu Honesty Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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ChangShu Haitian Fine Chemicals Co.,Ltd

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Ark Pharm, Inc.

Tel: 847-367-3680
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Email: sales@arkpharminc.com
Country: United States
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Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
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View Lastest Price from 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 18087-73-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2000
Release date: 2025-09-25

Shanghai Rlavie Technology Co ltd

Product: 3-bromoimidazo[1,2-b]pyridazine 18087-73-5
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 50kgs/month
Release date: 2021-11-13

Dideu Industries Group Limited

Product: 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 18087-73-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-02

18087-73-5, 3-BROMOIMIDAZO[1,2-B]PYRIDAZINERelated Search:

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 1-Methyl-4-[[4-nitro-2-(trifluoromethyl)phenyl]methyl]-piperazine BenzaMide, 3-iodo-4-Methyl-N-[4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)phenyl]- 3-Bromoimidazo[1,2-a]pyrimidine 3-Ethynylimidazo[1,2-b]pyridazine 4-Methyl-3-(trifluoromethyl)aniline 3-Iodo-4-methylbenzoic acid 2-METHYL-5-NITROBENZOTRIFLUORIDE 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 3-Bromo-6-chloroimidazo[1,2-b]pyridazine Imidazo[1,2-b]pyridazine 3,8-DIBROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE 3-BROMO-6-CHLORO-2-PHENYL-IMIDAZO[1,2-B]PYRIDAZINE 3-Bromo-2-phenylimidazo[1,2-b]pyridazine 3-Bromo-6-chloro-2-(4-chlorophenyl)imidazo[1,2-b]pyridazine 3-Bromo-6-piperidin-1-yl-imidazo[1,2-b]pyridazine 3-BROMO-7-METHYL-IMIDAZO[1,2-B]PYRIDAZINE 3-Bromo-6-pyrrolidin-1-yl-imidazo[1,2-b]pyridazine

IMidazo[1,2-b]pyridazine, 3-broMo-

3-BroMoiMidazo[1,2-b]pyri...

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE

3-broMoiMidazo(1,2-b)pyridazin

3-Bromoimidazo[1,2-<i>b</i>]pyridazine

Ponatinib Impurity 2

Ponatinib intermediate

3-Bromoimidazo[1,2-b]pyridazine &gt

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE 18087-73-5

3-BROMOIMIDAZO[1,2-B]PYRIDAZINE ISO 9001：2015 REACH

3-Bromo-4-Hydroimidazo[1,2-e]Pyridazine

18087-73-5