3-Bromo-[1,2,4]triazolo[4,3-a]pyridine

Product Name: 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
CAS No.: 4922-68-3
Chemical Name: 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
Synonyms: Ponatinib Impurity 9;s-Triazolo[4,3-a]pyridine, 3-bromo-;3-bromo-[1,2,4]triazolo[4,3-a]pyridine;1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO-
CBNumber: CB02456245
Molecular Formula: C6H4BrN3
Formula Weight: 198.02
MOL File: 4922-68-3.mol

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3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Property

Melting point:: 165-167 °C
Density: 1.89±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.97±0.50(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C6H4BrN3/c7-6-9-8-5-3-1-2-4-10(5)6/h1-4H
InChIKey: BOKHADJFZUWNSH-UHFFFAOYSA-N
SMILES: C12=NN=C(Br)N1C=CC=C2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H310Fatal in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B688425
Product name: 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
Packaging: 100mg
Price: $130
Updated: 2021/12/16

TRC

Product number: B688425
Product name: 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine
Packaging: 1g
Price: $935
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB46402
Product name: 3-Bromo[1,2,4]triazolo[4,3-a]pyridine
Packaging: 50mg
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB46402
Product name: 3-Bromo[1,2,4]triazolo[4,3-a]pyridine
Packaging: 100mg
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB46402
Product name: 3-Bromo[1,2,4]triazolo[4,3-a]pyridine
Packaging: 250mg
Price: $200
Updated: 2021/12/16

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3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Chemical Properties,Usage,Production

Uses

3-Bromo-[1,2,4]triazolo[4,3-a]pyridine is an intermediate used to prepare bi-aryl amines as mGluR5 modulators for treating gastrointestinal, urinary tract, and nervous system disorders.

Synthesis

274-80-6

4922-68-3

General procedure for the synthesis of 3-bromo-[1,2,4]triazolo[4,3-a]pyridine from [1,2,4]triazolo[4,3-a]pyridine: [1,2,4]triazolo[4,3-a]pyridine (1.26 g) and N-bromosuccinimide (NBS, 1.98 g) were dissolved in chloroform, and the reaction was carried out at reflux for 5 h followed by a 14-h stand at room temperature. Upon completion of the reaction, saturated aqueous potassium carbonate (200 mL) and potassium hydroxide (20 g) were added to the mixture, and the organic layer was separated after sufficient shaking. The aqueous layer was extracted twice with dichloromethane (DCM). All organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) followed by evaporation of the solvent under vacuum to afford the target product 3-bromo-[1,2,4]triazolo[4,3-a]pyridine in 60% yield.

References

[1] Patent: EP2743266, 2014, A2. Location in patent: Page/Page column

3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-[1,2,4]triazolo[4,3-a]pyridine Suppliers

China 88 Germany 1 India 4 United Kingdom 1 United States 9 Global 103

A.J Chemicals

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Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

Stereokem, Inc.

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Email: kumar@stereokem.com
Country: India
ProdList: 293
Advantage: 58

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View Lastest Price from 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Bromo-[1,2,4]triazolo[4,3-a]pyridine 4922-68-3
Price: US $1.00-2.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20000KG
Release date: 2024-08-09

Career Henan Chemical Co

Product: 1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 3-BROMO- 4922-68-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-03

4922-68-3, 3-Bromo-[1,2,4]triazolo[4,3-a]pyridineRelated Search:

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4922-68-3

Heterocycle-Pyridine series