ChemicalBook > CAS DataBase List > 5-CHLORO-2'-DEOXYURIDINE

5-CHLORO-2'-DEOXYURIDINE

Product Name
5-CHLORO-2'-DEOXYURIDINE
CAS No.
50-90-8
Chemical Name
5-CHLORO-2'-DEOXYURIDINE
Synonyms
CldU;CLUDR;NSC-371331, CDC;Chlorodeoxyuridine;5-Chlorodeoxyuridin;5-CHLORODEOXYURIDINE;5-CHLORODESOXYURIDINE;5-chloro-2’-deoxy-uridin;5-CHLORO-2'-DEOXYURIDINE;2'-DEOXY-5-CHLOROURIDINE
CBNumber
CB0246956
Molecular Formula
C9H11ClN2O5
Formula Weight
262.65
MOL File
50-90-8.mol
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5-CHLORO-2'-DEOXYURIDINE Property

Melting point:
176-179°C
Density 
1.5507 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
-20°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
pka
7.73±0.10(Predicted)
color 
White to Off-White
CAS DataBase Reference
50-90-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-40
Safety Statements 
36/37/39-45
WGK Germany 
3
RTECS 
YU7400000
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C6891
Product name
5-Chloro-2′-deoxyuridine
Purity
thymidine analog
Packaging
100mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
18155
Product name
5-Chloro-2''-deoxyuridine
Purity
≥98%
Packaging
25 mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
18155
Product name
5-Chloro-2'-deoxyuridine
Purity
≥98%
Packaging
50mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
18155
Product name
5-Chloro-2'-deoxyuridine
Purity
≥98%
Packaging
100mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
18155
Product name
5-Chloro-2'-deoxyuridine
Purity
≥98%
Packaging
250mg
Price
$149
Updated
2023/01/06
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5-CHLORO-2'-DEOXYURIDINE Chemical Properties,Usage,Production

Description

5-Chloro-2''-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.

Chemical Properties

White Needles

Uses

A halogenated uridine derivative used in pharmaceutical compositions.

Uses

5-Chloro-2'-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.[Cayman Chemical]

Uses

5-Chloro-2′-deoxyuridine (CldU) is used as a thymidine analog to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).

Biochem/physiol Actions

DNA labeled with 5-chloro-2′-deoxyuridine (CldU) serves as an effective tool to analyze and quantify DNA replication, repair, and recombination. CldU is a potent mutagen, clastogen, and toxicant. It is used as a thymidine analog and is found to alter the dNTP pools and might lead to cell-cycle arrest. CldU produces sister-chromatid exchange but has less response to ionizing radiation compared to other thymine analogs. 5-Chloro-2′-deoxyuridine (CldU) is used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).

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5-CHLORO-2'-DEOXYURIDINE Suppliers

Shanghai Yingxin laboratory equipment Co., Ltd
Tel
021-021-59178156 15300768757
Email
359382369@qq.com
Country
China
ProdList
10367
Advantage
58
Hangzhou FuRun Pharmaceutical Technology Co., Ltd
Tel
19975279805
Email
1900830611@qq.com
Country
China
ProdList
988
Advantage
58
Panaishen (Henan) Pharmaceutical Science and Technology Co. , Ltd.
Tel
0371-65325800 13700860222
Email
haifeng.zhang@pannacean.com
Country
China
ProdList
341
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
Nanjing Baifuli Technology Co., Ltd.
Tel
25-25-58740604 15951658055
Fax
+86-25-58356858
Email
sales@unisyn.cn
Country
China
ProdList
537
Advantage
58
Zhengzhou GranLen pharmaceutical Technology Co., Ltd.
Tel
0371-85513397
Email
info@granlen.com
Country
China
ProdList
497
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4528
Advantage
56
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View Lastest Price from 5-CHLORO-2'-DEOXYURIDINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
5-CHLORO-2"-DEOXYURIDINE 50-90-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

50-90-8, 5-CHLORO-2'-DEOXYURIDINERelated Search:


  • 2'-DEOXY-5-CHLOROURIDINE
  • 5-CHLORODESOXYURIDINE
  • 5-CHLORO-2'-DEOXYURIDINE
  • 5-chloro-2’-deoxy-uridin
  • 5-Chlorodeoxyuridin
  • 5-Chloro-2'-deoxy-D-uridine
  • 5-CHLORODEOXYURIDINE
  • Chlorodeoxyuridine
  • 5-CHLORO-1-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-3H-PYRIMIDINE-2,4-DIONE
  • CldU
  • CLUDR
  • 5-chloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  • 5-chloro-1-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone
  • 5-Chloro-2'-deoxyuridine ,98%
  • 5-chloro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • Uridine,5-chloro-2'-deoxy-
  • NSC-371331, CDC
  • 5-CHLORO-2'-DEOXYURIDINE USP/EP/BP
  • 5-Chloro-2’-deoxy uridine NSC-371331, CDC,Radio-sensitizing agent for cancer treatment,anticancer agent
  • Inhibitor,inhibit,5Chloro2'deoxyuridine,5 Chloro 2' deoxyuridine
  • 50-90-8
  • Biochemicals and Reagents
  • BioChemical
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleoside Analogs
  • API intermediates
  • Bases & Related Reagents
  • Carbohydrates & Derivatives
  • Heterocycles
  • Nucleotides
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides