5-CHLORO-2'-DEOXYURIDINE

ChemicalBook > CAS DataBase List > 5-CHLORO-2'-DEOXYURIDINE

5-CHLORO-2'-DEOXYURIDINE

Product Name: 5-CHLORO-2'-DEOXYURIDINE
CAS No.: 50-90-8
Chemical Name: 5-CHLORO-2'-DEOXYURIDINE
Synonyms: CldU;CLUDR;NSC-371331, CDC;Chlorodeoxyuridine;5-Chlorodeoxyuridin;5-CHLORODEOXYURIDINE;5-CHLORODESOXYURIDINE;5-chloro-2’-deoxy-uridin;5-CHLORO-2'-DEOXYURIDINE;2'-DEOXY-5-CHLOROURIDINE
CBNumber: CB0246956
Molecular Formula: C9H11ClN2O5
Formula Weight: 262.65
MOL File: 50-90-8.mol

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5-CHLORO-2'-DEOXYURIDINE Property

Melting point:: 176-179°C
Density: 1.5507 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
pka: 7.73±0.10(Predicted)
color: White to Off-White
CAS DataBase Reference: 50-90-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-40
Safety Statements: 36/37/39-45
WGK Germany: 3
RTECS: YU7400000
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6891
Product name: 5-Chloro-2′-deoxyuridine
Purity: thymidine analog
Packaging: 100mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 18155
Product name: 5-Chloro-2''-deoxyuridine
Purity: ≥98%
Packaging: 25 mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 18155
Product name: 5-Chloro-2'-deoxyuridine
Purity: ≥98%
Packaging: 50mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 18155
Product name: 5-Chloro-2'-deoxyuridine
Purity: ≥98%
Packaging: 100mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 18155
Product name: 5-Chloro-2'-deoxyuridine
Purity: ≥98%
Packaging: 250mg
Price: $149
Updated: 2023/01/06

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5-CHLORO-2'-DEOXYURIDINE Chemical Properties,Usage,Production

Description

5-Chloro-2''-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.

Chemical Properties

White Needles

Uses

A halogenated uridine derivative used in pharmaceutical compositions.

Uses

5-Chloro-2'-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.[Cayman Chemical]

Uses

5-Chloro-2′-deoxyuridine (CldU) is used as a thymidine analog to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).

Biochem/physiol Actions

DNA labeled with 5-chloro-2′-deoxyuridine (CldU) serves as an effective tool to analyze and quantify DNA replication, repair, and recombination. CldU is a potent mutagen, clastogen, and toxicant. It is used as a thymidine analog and is found to alter the dNTP pools and might lead to cell-cycle arrest. CldU produces sister-chromatid exchange but has less response to ionizing radiation compared to other thymine analogs. 5-Chloro-2′-deoxyuridine (CldU) is used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).

5-CHLORO-2'-DEOXYURIDINE Preparation Products And Raw materials

Raw materials

Sodium azide Acetonitrile Ceric ammonium nitrate Acetic anhydride Acetone 2'-Deoxyuridine Tetrahydrofuran N-Chlorosuccinimide Dichloromethane Methanol Sodium hydroxide Pyridine 1,2-Dimethoxyethane Lithium chloride

Preparation Products

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View Lastest Price from 5-CHLORO-2'-DEOXYURIDINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-CHLORO-2"-DEOXYURIDINE 50-90-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

50-90-8, 5-CHLORO-2'-DEOXYURIDINERelated Search:

2-Chloropropene UREA HYDROCHLORIDE 5-Chlorouridine 2-Chloro-N-methylacetamide 2'-Deoxyuridine 2',3'-Dideoxyuridine Chloroacetamide Trimethylamine hydrochloride 3-Dimethylamino-1-propanol Allylamine hydrochloride 5-Chlorouracil (Hydroxymethyl)urea 5-CHLORO-2'-DEOXYURIDINE 1,3-DIETHYLUREA 4-DIMETHYLAMINO-1-BUTANOL 3-AMINO-1-PROPANOL HYDROCHLORIDE 1-METHYLURACIL 2-CHLOROETHYLUREA

2'-DEOXY-5-CHLOROURIDINE

5-CHLORODESOXYURIDINE

5-CHLORO-2'-DEOXYURIDINE

5-chloro-2’-deoxy-uridin

5-Chlorodeoxyuridin

5-Chloro-2'-deoxy-D-uridine

5-CHLORODEOXYURIDINE

Chlorodeoxyuridine

5-CHLORO-1-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-3H-PYRIMIDINE-2,4-DIONE

CldU

CLUDR

5-chloro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

5-chloro-1-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone

5-Chloro-2'-deoxyuridine ,98%

5-chloro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione

Uridine,5-chloro-2'-deoxy-

NSC-371331, CDC

5-CHLORO-2'-DEOXYURIDINE USP/EP/BP

5-Chloro-2’-deoxy uridine NSC-371331, CDC,Radio-sensitizing agent for cancer treatment,anticancer agent

Inhibitor,inhibit,5Chloro2'deoxyuridine,5 Chloro 2' deoxyuridine

5-Chloro-2’-deoxyuridine

50-90-8

Biochemicals and Reagents

BioChemical

Nucleosides, Nucleotides, Oligonucleotides

Nucleoside Analogs

API intermediates

Bases & Related Reagents

Carbohydrates & Derivatives

Heterocycles

Nucleotides

Biochemicals and Reagents

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides