Di-tert-butyl Chloromethyl Phosphate
- Product Name
- Di-tert-butyl Chloromethyl Phosphate
- CAS No.
- 229625-50-7
- Chemical Name
- Di-tert-butyl Chloromethyl Phosphate
- Synonyms
- Di-tert-butyl Chloromethyl Phosphate;Phosphoric acid di-tert-butyl chloromethyl ester;Fostemsavir-SM;Foscarbidopa Impurity 20;Di-t-butyl chloromethyl phosphate;ditetrabutyl chloromethyl phosphate;Chloromethyl di-tert-butyl phosphate;Di-tert-butyl chloromethyl phosphate 95%;Di tertiary butyl chloromethyl phosphite;PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER
- CBNumber
- CB02515861
- Molecular Formula
- C9H20ClO4P
- Formula Weight
- 258.68
- MOL File
- 229625-50-7.mol
Di-tert-butyl Chloromethyl Phosphate Property
- Boiling point:
- 272.9±23.0 °C(Predicted)
- Density
- 1.115±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Benzene (Slightly), Methanol (Slightly)
- form
- clear liquid
- color
- Colorless to Light yellow
- Stability:
- Moisture Sensitive
- InChI
- InChI=1S/C9H20ClO4P/c1-8(2,3)13-15(11,12-7-10)14-9(4,5)6/h7H2,1-6H3
- InChIKey
- LNJAJHJFSKUCIR-UHFFFAOYSA-N
- SMILES
- P(OC(C)(C)C)(OC(C)(C)C)(OCCl)=O
- CAS DataBase Reference
- 229625-50-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D428028
- Product name
- Di-tert-butylChloromethylPhosphate(stabilizedwithK2CO3)
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD137343
- Product name
- Di-tert-butyl chloromethyl phosphate
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 092558
- Product name
- Di-tert-butyl (chloromethyl) phosphate (stabilized with potassium carbonate)
- Purity
- 95+%
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
- Product number
- FD137343
- Product name
- Di-tert-butyl chloromethyl phosphate
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FD137343
- Product name
- Di-tert-butyl chloromethyl phosphate
- Packaging
- 2g
- Price
- $160
- Updated
- 2021/12/16
Di-tert-butyl Chloromethyl Phosphate Chemical Properties,Usage,Production
Description
Di-tert-butyl (chloromethyl) phosphate has become one of the most common reagents to prepare phosphon-oxymethyl pro-drugs, generally by direct alkylation of hydroxyl or amino groups. Its synthesis was first reported in 1999 via a reaction of di-tert-butyl tetramethylammonium phosphate with chloroiodomethane. This approach required the use of the corresponding tetramethylammonium phosphate and a vast excess (>11 equiv) of chloroiodomethane to minimize the formation of tetra-tert-butyl methylene bisphosphate[1].
Uses
Used as an intermediate for laboratory research.
Synthesis
Di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs, is prepared by reacting chloromethyl chlorosulfate (CMCS) with di-tert-butyl potassium phosphate (DTBPP) .
References
[1] Bin Zheng*. “Development of Efficient Processes for the Preparation of Di-tert-butyl Potassium Phosphate and Di-tert-butyl (Chloromethyl) Phosphate.” Organic Process Research & Development 18 5 (2014): 636–642.
Di-tert-butyl Chloromethyl Phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Di-tert-butyl Chloromethyl Phosphate manufacturers
- Product
- Di-Tert-Butyl Chloromethyl Phosphate 229625-50-7
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-23
- Product
- Di-tert-butyl Chloromethyl Phosphate 229625-50-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-09-26
- Product
- Di-tert-butyl Chloromethyl Phosphate 229625-50-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 MT
- Release date
- 2024-05-13