ChemicalBook > CAS DataBase List > LDN-193189 HCl

LDN-193189 HCl

Product Name
LDN-193189 HCl
CAS No.
1062368-62-0
Chemical Name
LDN-193189 HCl
Synonyms
CS-1451;LDN-193189 HCl;LDN-193189 4HCl;LDN-193189 HCl USP/EP/BP;LDN193189 (Hydrochloride);LDN-193189 HCL;LDN 193189 HCL;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl;LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE;LDN193189 hydrochloride, 98%, a selective BMP type I receptor kinases inhibitor;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride
CBNumber
CB02517951
Molecular Formula
C25H23ClN6
Formula Weight
442.94332
MOL File
1062368-62-0.mol
More
Less

LDN-193189 HCl Property

Melting point:
>240°C (dec.)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Methanol (Slightly), DMSO (Very Slightly, Heated)
form 
Solid
color 
Dark Orange
CAS DataBase Reference
1062368-62-0
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$75
Updated
2021/12/16
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2021/12/16
Cayman Chemical
Product number
19396
Product name
LDN-193189 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$300
Updated
2021/12/16
TRC
Product number
P480133
Product name
LDN193189 hydrochloride
Packaging
10mg
Price
$195
Updated
2021/12/16
More
Less

LDN-193189 HCl Chemical Properties,Usage,Production

Uses

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Hydrochoride is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases.

Uses

LDN-193189 HCl has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

Biological Activity

ldn193189 is a selective transcriptional activity morphogenetic protein (bmp) type i receptors inhibitor. it inhibits activin receptor-like kinase-2 (alk2) and alk3 with ic50 values of 5 nm and 30 nm, respectively [1].ldn193189 has been showed to inhibit bmp induced phosphorylation of smad signaling (smad1/5/8) and non-smad signaling including p38 and akt in c2c12 cells [2].pharmacological inhibition of bmp by ldn193189 has shown to prevent down-regulation of e-cadherin in response to bmp2 both in bronchial epithelial (beas2b) cells and in c57bl/6 mice. ldn193189 also inhibits the bmp-induced reduction of epithelial permeability at cellular level [3].

References

[1] yu pb, deng dy, lai cs, hong cc, cuny gd, bouxsein ml, hong dw, mcmanus pm, katagiri t, sachidanandan c, kamiya n, fukuda t, mishina y, peterson rt, bloch kd. bmp type i receptor inhibition reduces heterotopic [corrected] ossification. nat med. 2008 dec;14(12):1363-9.
[2] boergermann jh1, kopf j, yu pb, knaus p. dorsomorphin and ldn-193189 inhibit bmp-mediated smad, p38 and akt signalling in c2c12 cells. int j biochem cell biol. 2010 nov;42(11):1802-7.
[3] helbing t1, herold em, hornstein a, wintrich s, heinke j, grundmann s, patterson c, bode c, moser m. inhibition of bmp activity protects epithelial barrier function in lung injury. j pathol. 2013 sep;231(1):105-16. doi: 10.1002/path.4215. epub 2013 jul 10.

LDN-193189 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

LDN-193189 HCl Suppliers

China 83 India 1 The Netherlands 1 United States 13 Global 98
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30
More
Less

View Lastest Price from LDN-193189 HCl manufacturers

Career Henan Chemical Co
Product
LDN-193189 HCl 1062368-62-0
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-23

1062368-62-0, LDN-193189 HClRelated Search:

LDN-214117 LDN-193189 LDN212854 LDN-212320 Y27632 (hydrochloride) SB 431542 Purmorphamine K 02288 CHIR-99021 Rapamycin

  • 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride
  • 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl
  • LDN193189 (Hydrochloride)
  • 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride (1:1)
  • LDN-193189 HCl
  • LDN193189 hydrochloride, 98%, a selective BMP type I receptor kinases inhibitor
  • LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE
  • LDN-193189 HCL;LDN 193189 HCL
  • CS-1451
  • LDN-193189 HCl USP/EP/BP
  • LDN-193189 4HCl
  • 1062368-62-0
  • C25H26Cl4N6
  • C25H22N6HCl
  • C25H22N6ClH
  • Inhibitors