LDN-193189 HCl

Product Name: LDN-193189 HCl
CAS No.: 1062368-62-0
Chemical Name: LDN-193189 HCl
Synonyms: CS-1451;LDN-193189 HCl;LDN-193189 4HCl;LDN-193189 HCl USP/EP/BP;LDN193189 (Hydrochloride);LDN-193189 HCL;LDN 193189 HCL;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl;LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE;LDN193189 hydrochloride, 98%, a selective BMP type I receptor kinases inhibitor;4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride
CBNumber: CB02517951
Molecular Formula: C25H23ClN6
Formula Weight: 442.94332
MOL File: 1062368-62-0.mol

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LDN-193189 HCl Property

Melting point:: >240°C (dec.)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Methanol (Slightly), DMSO (Very Slightly, Heated)
form: Solid
color: Dark Orange
CAS DataBase Reference: 1062368-62-0

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19396
Product name: LDN-193189 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2021/12/16

Cayman Chemical

Product number: 19396
Product name: LDN-193189 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $75
Updated: 2021/12/16

Cayman Chemical

Product number: 19396
Product name: LDN-193189 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2021/12/16

Cayman Chemical

Product number: 19396
Product name: LDN-193189 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $300
Updated: 2021/12/16

TRC

Product number: P480133
Product name: LDN193189 hydrochloride
Packaging: 10mg
Price: $195
Updated: 2021/12/16

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LDN-193189 HCl Chemical Properties,Usage,Production

Uses

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Hydrochoride is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases.

Uses

LDN-193189 HCl has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

Biological Activity

ldn193189 is a selective transcriptional activity morphogenetic protein (bmp) type i receptors inhibitor. it inhibits activin receptor-like kinase-2 (alk2) and alk3 with ic50 values of 5 nm and 30 nm, respectively [1].ldn193189 has been showed to inhibit bmp induced phosphorylation of smad signaling (smad1/5/8) and non-smad signaling including p38 and akt in c2c12 cells [2].pharmacological inhibition of bmp by ldn193189 has shown to prevent down-regulation of e-cadherin in response to bmp2 both in bronchial epithelial (beas2b) cells and in c57bl/6 mice. ldn193189 also inhibits the bmp-induced reduction of epithelial permeability at cellular level [3].

References

[1] yu pb, deng dy, lai cs, hong cc, cuny gd, bouxsein ml, hong dw, mcmanus pm, katagiri t, sachidanandan c, kamiya n, fukuda t, mishina y, peterson rt, bloch kd. bmp type i receptor inhibition reduces heterotopic [corrected] ossification. nat med. 2008 dec;14(12):1363-9.
[2] boergermann jh1, kopf j, yu pb, knaus p. dorsomorphin and ldn-193189 inhibit bmp-mediated smad, p38 and akt signalling in c2c12 cells. int j biochem cell biol. 2010 nov;42(11):1802-7.
[3] helbing t1, herold em, hornstein a, wintrich s, heinke j, grundmann s, patterson c, bode c, moser m. inhibition of bmp activity protects epithelial barrier function in lung injury. j pathol. 2013 sep;231(1):105-16. doi: 10.1002/path.4215. epub 2013 jul 10.

LDN-193189 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN-193189 HCl Suppliers

China 83 India 1 The Netherlands 1 United States 13 Global 98

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View Lastest Price from LDN-193189 HCl manufacturers

Career Henan Chemical Co

Product: LDN-193189 HCl 1062368-62-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-23

1062368-62-0, LDN-193189 HClRelated Search:

LDN-214117 LDN-193189 LDN212854 LDN-212320 Y27632 (hydrochloride) SB 431542 Purmorphamine K 02288 CHIR-99021 Rapamycin

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl

LDN193189 (Hydrochloride)

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride (1:1)

LDN-193189 HCl

LDN193189 hydrochloride, 98%, a selective BMP type I receptor kinases inhibitor

LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE

LDN-193189 HCL;LDN 193189 HCL

CS-1451

LDN-193189 HCl USP/EP/BP

LDN-193189 4HCl

1062368-62-0

C25H26Cl4N6

C25H22N6HCl

C25H22N6ClH

Inhibitors