(R)-3-Methylmorpholine hydrochloride
- Product Name
- (R)-3-Methylmorpholine hydrochloride
- CAS No.
- 953780-78-4
- Chemical Name
- (R)-3-Methylmorpholine hydrochloride
- Synonyms
- (R)-3-MethylMorpholine HCl;(3R)-3-Methylmorpholine HCl;(R)-3-Methylmorpholine chloride;(R)-3-Methylmorpholine hydrochloride;(3R)-3-Methylmorpholine hydrochloride;O-Benzyl-L-Threoninebenzyleser oxalate;(3R)-3-Methylmorpholine hydrochloride 98%;(R)-3-Methylmorpholine Hydrochloride;Morpholine, 3-methyl-, hydrochloride, (3R)-;(3R)-3-methyl-Morpholine hydrochloride (1:1)
- CBNumber
- CB02520102
- Molecular Formula
- C5H12ClNO
- Formula Weight
- 137.61
- MOL File
- 953780-78-4.mol
(R)-3-Methylmorpholine hydrochloride Property
- Melting point:
- 123.0 to 127.0 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- color
- White to Orange to Green
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M2847
- Product name
- (R)-3-Methylmorpholine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 200mg
- Price
- $47
- Updated
- 2025/07/31
- Product number
- M2847
- Product name
- (R)-3-Methylmorpholine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $138
- Updated
- 2025/07/31
- Product number
- 4H56-5-CX
- Product name
- (R)-3-Methylmorpholine hydrochloride
- Purity
- 98%
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- X4857
- Product name
- (3R)-3-methylmorpholinehydrochloride
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- AS12233-B
- Product name
- (R)-3-Methyl-morpholine HCl
- Purity
- 95% ee
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
(R)-3-Methylmorpholine hydrochloride Chemical Properties,Usage,Production
Uses
(3R)-3-Methylmorpholine Hydrochloride is used in the discovery studies of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally active GSK-3β inhibitors for Alzheimer''s disease
Synthesis
954133-47-2
953780-78-4
General procedure for the synthesis of (R)-3-methylmorpholine hydrochloride from the compound (CAS: 954133-47-2): to a solution of (5R)-4-(4-methoxybenzyl)-5-methylmorpholine (17.8 g, 80.3 mmol) in 1,2-dichloroethane (180 mL) was added 1-chloroethyl chloroformate (46 g, 322 mmol). The reaction mixture was stirred at 80 °C for 6 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was dissolved in methanol (180 mL) and stirred at 80 °C for 1 hour. The solvent was again removed by evaporation under reduced pressure and the residue was washed with ethyl acetate and dried to give (3R)-3-methylmorpholine hydrochloride (8.2 g, 59.6 mmol, 74% yield) as white crystals.
References
[1] Patent: WO2007/119463, 2007, A1. Location in patent: Page/Page column 197; 198
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 5, p. 1086 - 1091
(R)-3-Methylmorpholine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-3-Methylmorpholine hydrochloride Suppliers
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 027- 51832457 94518350
- Fax
- E-Mail Inquiry
- Country
- China
- ProdList
- 746
- Advantage
- 62
- Tel
- 029-68669089-8816
- Fax
- +86-29-68669073
- market@xarlm.com
- Country
- China
- ProdList
- 499
- Advantage
- 55
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from (R)-3-Methylmorpholine hydrochloride manufacturers
- Product
- (R)-3-Methylmorpholine hydrochloride 953780-78-4
- Price
- US $2.80/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-24
- Product
- (R)-3-methylmorpholine hydrochloride 953780-78-4
- Price
- US $2.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-11-26
- Product
- (R)-3-methylmorpholine hydrochloride 953780-78-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95--99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09